MDR1 Antibody, clone JSB-1 | EMD Millipore MAB4120 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MDR1 Antibody, clone JSB-1

catalog :

MAB4120

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

JSB-1

The same clone is also sold as:

LifeSpan Biosciences: LS-C312100, LS-C122115, LS-C85155, LS-B5570
Enzo Life Sciences: ALX-801-004-C250, ALX-801-004-C125
Invitrogen: MA1-26530
BioLegend: 901401

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:200	Finalet Ferreiro J, Rouhigharabaei L, Urbankova H, van der Krogt J, Michaux L, Shetty S, et al. Integrative genomic and transcriptomic analysis identified candidate genes implicated in the pathogenesis of hepatosplenic T-cell lymphoma. PLoS ONE. 2014;9:e102977 pubmed publisher
immunohistochemistry - paraffin section; human; 1:20 western blot; human; 1:50; fig 1	Veringa S, Biesmans D, van Vuurden D, Jansen M, Wedekind L, Horsman I, et al. In vitro drug response and efflux transporters associated with drug resistance in pediatric high grade glioma and diffuse intrinsic pontine glioma. PLoS ONE. 2013;8:e61512 pubmed publisher
	Chen Y, Bieber M, Teng N. Hedgehog signaling regulates drug sensitivity by targeting ABC transporters ABCB1 and ABCG2 in epithelial ovarian cancer. Mol Carcinog. 2014;53:625-34 pubmed publisher

product information

Catalog Number :

MAB4120

Subcategory :

Metabolism

Product Name :

Anti-MDR1 Antibody, clone JSB-1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08183

Host Name :

Mouse

Antigen :

MDR1

Clone :

JSB-1

Conjugate :

Culture Supernatant

Isotype :

IgG1

Product Description :

Anti-MDR1 Antibody, clone JSB-1

Cross Reactivity :

Human;Hamster

ALT Names :

P-glycoprotein; CD243; p170; Pgp

Specificity :

Reacts with a conserved cytoplasmic epitope of the plasma membrane-associated 170 kDa P-gp, member of the superfamily of transmembrane transporters. JSB-1 detects P-gp overexpression in human tumor cells of all different histogenetic derivations. JSB-1 does not cross-react with MDR3 P-glycoprotein. JSB-1 has been shown to cross-react with Pyruvate Carboxylase (PC), an abundant Mr 130,000 mitochondrial enzyme, on both immunoblots and immunohistochemical tissue sections [Rao et al. (1995). J Histo. Cytochem. 43(12):1187-1192.] Unequivocal plasma membrane patterns of immunostaining represent true P-glycoprotein ex-presssion. Weak homogeneous, cytoplasmic, or granular patterns of reactivity may represent staining of the PC cross-reactive epitope rather than positive staining for P-glycoprotein.

Package Size :

100 μg

Uses :

Flow Cytometry;Immunocytochemistry;Immunohistochemistry (Paraffin);Western Blotting

Storage :

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.