GluR2 Antibody, clone 6C4, Alexa Fluor® 488 Conjugate | EMD Millipore MAB397A4 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

GluR2 Antibody, clone 6C4, Alexa Fluor® 488 Conjugate

catalog :

MAB397A4

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

6C4

The same clone is also sold as:

Invitrogen: 32-0300
BD Biosciences: 556341
LifeSpan Biosciences: LS-C15366

reactivity :

mouse, rat

application :

immunohistochemistry, immunocytochemistry

product information

Catalog Number :

MAB397A4

Subcategory :

Neuroscience

Product Name :

Anti-GluR2 Antibody, clone 6C4, Alexa Fluor® 488 Conjugate

Product Type :

Antibodies

Gene ID :

P19491

Host Name :

Mouse

Antigen :

GluR2

Conjugate :

AlexaFluor®488

Isotype :

IgG2a

Product Description :

Anti-GluR2 Antibody, clone 6C4, Alexa Fluor® 488 Conjugate

Cross Reactivity :

Mouse;Rat

Background :

Glutamate receptors (GluRs) can be categorized as ionotropic or metabotropic and subcatergorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. In general, AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. Although subunit composition of AMPA receptors varies, they must contain at least one edited GluR2 subunit to be calcium impermeable. The critical residue controlling calcium permeability is in the pore loop region. In GluR1, GluR3, and GluR4, this positionis occupied by a Gln residue. In GluR2, it is occupied by an Arg residue. It has been shown experimentally that the presence of Arg in this position blocks CA2+ ion permeability, while a Gln does not. Relative calcium permeability in AMPA receptor channels may be significant in pathological neurotoxic damage and long term changes in nervous system responses.

ALT Names :

Glutamate receptor 2;GluR-2;AMPA-selective glutamate receptor 2;GluR-B;GluR-K2;Glutamate receptor ionotropic, AMPA 2

Immunogen :

Recombinant fusion protein TrpE-GluR2

Specificity :

Recognizes the large N-terminal extracellular domain of Glutamate Receptor 2 (GluR2). No cross-reactivity observed with other AMPA/Kainate GluR subunits.

Package Size :

100 µL

Uses :

Immunohistochemistry;Immunocytochemistry

Storage :

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.