This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Glutamate Receptor 2
catalog :
MAB397
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
6C4

The same clone is also sold as:
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section
citations: 57
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 1d
Yan J, Bengtson C, Buchthal B, Hagenston A, Bading H. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020;370: pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; fig 3b
Zhao J, Li G, Zhao X, Lin X, Gao Y, Raimundo N, et al. Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss. Aging (Albany NY). 2020;12:5590-5611 pubmed publisher
  • immunocytochemistry; mouse; 1:200; loading ...; fig 1i
  • western blot; mouse; 1:1000; loading ...; fig 1d
Rodriguez Ortiz C, Prieto G, Martini A, Forner S, Trujillo Estrada L, LaFerla F, et al. miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease. Aging Cell. 2020;19:e13118 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 3b
  • western blot; mouse; 1:1000; loading ...; fig 6c
Coccia E, Planells Ferrer L, Badillos Rodríguez R, Pascual M, Segura M, Fernández Hernández R, et al. SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L. Cell Death Dis. 2020;11:82 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig s3b
Evonuk K, Doyle R, Moseley C, Thornell I, Adler K, Bingaman A, et al. Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation. Sci Adv. 2020;6:eaax5936 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 3f
Li Q, Lu T, Zhang C, Hansen M, Li S. Electrical stimulation induces synaptic changes in the peripheral auditory system. J Comp Neurol. 2019;: pubmed publisher
  • western blot; mouse; loading ...; fig 12c
Nakamoto C, Konno K, Miyazaki T, Nakatsukasa E, Natsume R, Abe M, et al. Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain. J Comp Neurol. 2019;: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a
Wagner W, Lippmann K, Heisler F, Gromova K, Lombino F, Roesler M, et al. Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression. Cell Rep. 2019;28:11-20.e9 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig s4d
Betto T, Amano H, Ito Y, Eshima K, Yoshida T, Matsui Y, et al. Vascular endothelial growth factor receptor 1 tyrosine kinase signaling facilitates healing of DSS-induced colitis by accumulation of Tregs in ulcer area. Biomed Pharmacother. 2019;111:131-141 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s6c
Wang Y, Figueiredo D, Sun X, Dong Z, Chen W, Cui W, et al. Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. Proc Natl Acad Sci U S A. 2018;115:2508-2513 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; fig 2j
Huang H, Lin X, Liang Z, Zhao T, Du S, Loy M, et al. Cdk5-dependent phosphorylation of liprin?1 mediates neuronal activity-dependent synapse development. Proc Natl Acad Sci U S A. 2017;114:E6992-E7001 pubmed publisher
  • immunohistochemistry; mouse; 1:2000; loading ...
Suzuki J, Hashimoto K, Xiao R, Vandenberghe L, Liberman M. Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction. Sci Rep. 2017;7:45524 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 1F
Zhong C, Akmentin W, DU C, Role L, Talmage D. Axonal Type III Nrg1 Controls Glutamate Synapse Formation and GluA2 Trafficking in Hippocampal-Accumbens Connections. Eneuro. 2017;4: pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Barad Z, Grattan D, Leitch B. NMDA Receptor Expression in the Thalamus of the Stargazer Model of Absence Epilepsy. Sci Rep. 2017;7:42926 pubmed publisher
  • western blot; rat; 1:2000; loading ...; fig 8d
Li J, Xie X, Li Y, Liu X, Liao X, Su Y, et al. Differential Behavioral and Neurobiological Effects of Chronic Corticosterone Treatment in Adolescent and Adult Rats. Front Mol Neurosci. 2017;10:25 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 9i
  • western blot; mouse; loading ...; fig 9k
Niu Y, Dai Z, Liu W, Zhang C, Yang Y, Guo Z, et al. Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory. elife. 2017;6: pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig s5
Abraira V, Kuehn E, Chirila A, Springel M, Toliver A, Zimmerman A, et al. The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell. 2017;168:295-310.e19 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 7b
Le H, Ahn B, Lee H, Shin A, Chae S, Lee S, et al. Disruption of Ninjurin1 Leads to Repetitive and Anxiety-Like Behaviors in Mice. Mol Neurobiol. 2017;54:7353-7368 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; tbl 1
Adotevi N, Leitch B. Alterations in AMPA receptor subunit expression in cortical inhibitory interneurons in the epileptic stargazer mutant mouse. Neuroscience. 2016;339:124-138 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 2
Laramée M, Smolders K, Hu T, Bronchti G, Boire D, Arckens L. Congenital Anophthalmia and Binocular Neonatal Enucleation Differently Affect the Proteome of Primary and Secondary Visual Cortices in Mice. PLoS ONE. 2016;11:e0159320 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4a
Wang Y, Hersheson J, López D, Hammer M, Liu Y, Lee K, et al. Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Cell Rep. 2016;16:79-91 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:400; loading ...; fig 5d
Wang Z, Fan J, Wang J, Li Y, Duan D, Du G, et al. Chronic cerebral hypoperfusion induces long-lasting cognitive deficits accompanied by long-term hippocampal silent synapses increase in rats. Behav Brain Res. 2016;301:243-52 pubmed publisher
Royo M, Gutiérrez Y, Fernandez Monreal M, Gutiérrez Eisman S, Jimenez R, Jurado S, et al. A retention-release mechanism based on RAB11FIP2 for AMPA receptor synaptic delivery during long-term potentiation. J Cell Sci. 2019;132: pubmed publisher
Itoh K, Murata D, Kato T, Yamada T, Araki Y, Saito A, et al. Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division. elife. 2019;8: pubmed publisher
Chokshi V, Gao M, Grier B, Owens A, Wang H, Worley P, et al. Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling. Neuron. 2019;104:736-748.e6 pubmed publisher
Ge Y, Tian M, Liu L, Wong T, Gong B, Wu D, et al. p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression. Nat Commun. 2019;10:4089 pubmed publisher
Tischbein M, Baron D, Lin Y, Gall K, Landers J, Fallini C, et al. The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing. J Biol Chem. 2019;: pubmed publisher
Edfawy M, Guedes J, Pereira M, Laranjo M, Carvalho M, Gao X, et al. Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice. Nat Commun. 2019;10:1431 pubmed publisher
Taylor B, Sinha G, Donahue R, Grachen C, Morón J, Doolen S. Opioid receptors inhibit the spinal AMPA receptor Ca2+ permeability that mediates latent pain sensitization. Exp Neurol. 2019;314:58-66 pubmed publisher
Siemsen B, Giannotti G, McFaddin J, Scofield M, McGinty J. Biphasic effect of abstinence duration following cocaine self-administration on spine morphology and plasticity-related proteins in prelimbic cortical neurons projecting to the nucleus accumbens core. Brain Struct Funct. 2019;224:741-758 pubmed publisher
Ha H, Leal Ortiz S, Lalwani K, Kiyonaka S, Hamachi I, Mysore S, et al. Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons. Front Mol Neurosci. 2018;11:405 pubmed publisher
Ramos Vicente D, Ji J, Gratacòs Batlle E, Gou G, Reig Viader R, Luís J, et al. Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events. elife. 2018;7: pubmed publisher
Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, et al. Deficiency of AMPAR-Palmitoylation Aggravates Seizure Susceptibility. J Neurosci. 2018;38:10220-10235 pubmed publisher
Blanco Suarez E, Liu T, Kopelevich A, Allen N. Astrocyte-Secreted Chordin-like 1 Drives Synapse Maturation and Limits Plasticity by Increasing Synaptic GluA2 AMPA Receptors. Neuron. 2018;100:1116-1132.e13 pubmed publisher
Angueyra J, Kindt K. Leveraging Zebrafish to Study Retinal Degenerations. Front Cell Dev Biol. 2018;6:110 pubmed publisher
Repetto D, Brockhaus J, Rhee H, Lee C, Kilimann M, Rhee J, et al. Molecular Dissection of Neurobeachin Function at Excitatory Synapses. Front Synaptic Neurosci. 2018;10:28 pubmed publisher
Simhal A, Gong B, Trimmer J, Weinberg R, Smith S, Sapiro G, et al. A Computational Synaptic Antibody Characterization Tool for Array Tomography. Front Neuroanat. 2018;12:51 pubmed publisher
He H, Shen W, Zheng L, Guo X, Cline H. Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity. Nat Commun. 2018;9:2893 pubmed publisher
Boero L, Castagna V, Di Guilmi M, Goutman J, Elgoyhen A, Gómez Casati M. Enhancement of the Medial Olivocochlear System Prevents Hidden Hearing Loss. J Neurosci. 2018;38:7440-7451 pubmed publisher
Studniarczyk D, Needham E, Mitchison H, Farrant M, Cull Candy S. Altered Cerebellar Short-Term Plasticity but No Change in Postsynaptic AMPA-Type Glutamate Receptors in a Mouse Model of Juvenile Batten Disease. Eneuro. 2018;5: pubmed publisher
Rajgor D, Sanderson T, Amici M, Collingridge G, Hanley J. NMDAR-dependent Argonaute 2 phosphorylation regulates miRNA activity and dendritic spine plasticity. EMBO J. 2018;37: pubmed publisher
Larsson M. Non-canonical heterogeneous cellular distribution and co-localization of CaMKIIα and CaMKIIβ in the spinal superficial dorsal horn. Brain Struct Funct. 2018;223:1437-1457 pubmed publisher
Cai R, Montgomery S, Graves K, Caspary D, Cox B. The FBN rat model of aging: investigation of ABR waveforms and ribbon synapse changes. Neurobiol Aging. 2018;62:53-63 pubmed publisher
Nakayama K, Ohashi R, Shinoda Y, Yamazaki M, Abe M, Fujikawa A, et al. RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation. elife. 2017;6: pubmed publisher
Anderson G, Maxeiner S, Sando R, Tsetsenis T, Malenka R, Südhof T. Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly. J Cell Biol. 2017;216:3831-3846 pubmed publisher
Li M, Miao W, Wu Q, He S, Yan G, Yang Y, et al. A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex. Neuron. 2017;94:1155-1172.e8 pubmed publisher
Sullivan S, Farrant M, Cull Candy S. TARP ?-2 Is Required for Inflammation-Associated AMPA Receptor Plasticity within Lamina II of the Spinal Cord Dorsal Horn. J Neurosci. 2017;37:6007-6020 pubmed publisher
Sebe J, Cho S, SHEETS L, Rutherford M, von Gersdorff H, Raible D. Ca2+-Permeable AMPARs Mediate Glutamatergic Transmission and Excitotoxic Damage at the Hair Cell Ribbon Synapse. J Neurosci. 2017;37:6162-6175 pubmed publisher
Wu D, Bacaj T, Morishita W, Goswami D, Arendt K, Xu W, et al. Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP. Nature. 2017;544:316-321 pubmed publisher
Chen A, Chen Y, Tang Y, Bao C, Cui Z, Xiao M, et al. Hippocampal AMPARs involve the central sensitization of rats with irritable bowel syndrome. Brain Behav. 2017;7:e00650 pubmed publisher
Divakaruni A, Wallace M, Buren C, Martyniuk K, Andreyev A, Li E, et al. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. J Cell Biol. 2017;216:1091-1105 pubmed publisher
Radzicki D, Pollema Mays S, Sanz Clemente A, Martina M. Loss of M1 Receptor Dependent Cholinergic Excitation Contributes to mPFC Deactivation in Neuropathic Pain. J Neurosci. 2017;37:2292-2304 pubmed publisher
Sinnen B, Bowen A, Forte J, Hiester B, Crosby K, Gibson E, et al. Optogenetic Control of Synaptic Composition and Function. Neuron. 2017;93:646-660.e5 pubmed publisher
Minbay Z, Serter Kocoglu S, Gok Yurtseven D, Eyigor O. Immunohistochemical localization of ionotropic glutamate receptors in the rat red nucleus. Bosn J Basic Med Sci. 2017;17:29-37 pubmed publisher
Kooijmans R, Self M, Wouterlood F, Belien J, Roelfsema P. Inhibitory interneuron classes express complementary AMPA-receptor patterns in macaque primary visual cortex. J Neurosci. 2014;34:6303-15 pubmed publisher
Wang J, Ben Hamida S, Darcq E, Zhu W, Gibb S, Lanfranco M, et al. Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior. J Neurosci. 2012;32:15124-32 pubmed publisher
Henkemeyer M, Itkis O, Ngo M, Hickmott P, Ethell I. Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus. J Cell Biol. 2003;163:1313-26 pubmed
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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