This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Myelin Basic Protein Antibody, a.a. 82-87
catalog :
MAB386
quantity :
1 mL
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
12

The same clone is also sold as:
reactivity :
African green monkey, human, mouse, rat, chicken, bovine, pigs , domestic sheep
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, radioimmunoassay, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
citations: 108
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; pigs ; 1:100; loading ...; fig 1i, 1j, 1k
Swier V, White K, Meyerholz D, Chefdeville A, Khanna R, Sieren J, et al. Validating indicators of CNS disorders in a swine model of neurological disease. PLoS ONE. 2020;15:e0228222 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 6c, d, e
Shibahara T, Ago T, Nakamura K, Tachibana M, Yoshikawa Y, Komori M, et al. Pericyte-Mediated Tissue Repair through PDGFRβ Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke. Eneuro. 2020;7: pubmed publisher
  • western blot; rat; 1:200; loading ...; fig 4b-d
Werkman I, Sikkema A, Versluijs J, Qin J, de Boer P, Baron W. TLR3 agonists induce fibronectin aggregation by activated astrocytes: a role of pro-inflammatory cytokines and fibronectin splice variants. Sci Rep. 2020;10:532 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:200; loading ...; fig s9
Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler R, Zhang S, et al. Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model. Nat Neurosci. 2019;22:719-728 pubmed publisher
  • immunohistochemistry - paraffin section; domestic sheep; 1:1000; loading ...; fig 5a
Gussenhoven R, Westerlaken R, Ophelders D, Jobe A, Kemp M, Kallapur S, et al. Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus. J Neuroinflammation. 2018;15:113 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 2e
Ogawa Y, Kakumoto K, Yoshida T, Kuwako K, Miyazaki T, Yamaguchi J, et al. Elavl3 is essential for the maintenance of Purkinje neuron axons. Sci Rep. 2018;8:2722 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 2c
Yungher B, Ribeiro M, Park K. Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice. Invest Ophthalmol Vis Sci. 2017;58:1743-1750 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:500; fig s1a
Kuipers H, Yoon J, van Horssen J, Han M, Bollyky P, Palmer T, et al. Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination. Proc Natl Acad Sci U S A. 2017;114:E1745-E1754 pubmed publisher
  • immunocytochemistry; African green monkey; 1:50; loading ...; fig 1M
  • immunocytochemistry; human; 1:50; loading ...; fig 4K
Yamashita T, Miyamoto Y, Bando Y, Ono T, Kobayashi S, Doi A, et al. Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells. PLoS ONE. 2017;12:e0171947 pubmed publisher
  • immunohistochemistry; rat; 1:500; fig 2
Moruzzo D, Nobbio L, Sterlini B, Consalez G, Benfenati F, Schenone A, et al. The Transcription Factors EBF1 and EBF2 Are Positive Regulators of Myelination in Schwann Cells. Mol Neurobiol. 2017;54:8117-8127 pubmed publisher
  • immunocytochemistry; rat; 1:300; loading ...; fig 3f
Syed Y, Abdulla S, Kotter M. Studying the Effects of Semaphorins on Oligodendrocyte Lineage Cells. Methods Mol Biol. 2017;1493:363-378 pubmed
  • immunocytochemistry; mouse; 1:100; loading ...; fig 1d
  • immunohistochemistry; mouse; 1:100; loading ...; fig 6a
  • western blot; rat; 1:100; fig 1i
Redmond S, Mei F, Eshed Eisenbach Y, Osso L, Leshkowitz D, Shen Y, et al. Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination. Neuron. 2016;91:824-836 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:500; loading ...; fig s4d
Wolf H, Damme M, Stroobants S, D Hooge R, Beck H, Hermans Borgmeyer I, et al. A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease. Dis Model Mech. 2016;9:1015-28 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig s.1
Mann A, Scodeller P, Hussain S, Joo J, Kwon E, Braun G, et al. A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries. Nat Commun. 2016;7:11980 pubmed publisher
  • immunocytochemistry; mouse; fig 1
Kizuka Y, Nakano M, Miura Y, Taniguchi N. Epigenetic regulation of neural N-glycomics. Proteomics. 2016;16:2854-2863 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 2
Douvaras P, Rusielewicz T, Kim K, Haines J, CASACCIA P, Fossati V. Epigenetic Modulation of Human Induced Pluripotent Stem Cell Differentiation to Oligodendrocytes. Int J Mol Sci. 2016;17: pubmed publisher
  • immunohistochemistry - frozen section; human; 1:200; fig 1
  • immunocytochemistry; human; 1:200; fig s4
Deborde S, Omelchenko T, Lyubchik A, Zhou Y, He S, McNamara W, et al. Schwann cells induce cancer cell dispersion and invasion. J Clin Invest. 2016;126:1538-54 pubmed publisher
  • immunohistochemistry; mouse; 1:300; fig 3
Yang H, Vainshtein A, Maik Rachline G, Peles E. G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination. Nat Commun. 2016;7:10884 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:2000; fig 2
Sharma A, Lyashchenko A, Lu L, Nasrabady S, Elmaleh M, Mendelsohn M, et al. ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function. Nat Commun. 2016;7:10465 pubmed publisher
  • immunohistochemistry - paraffin section; domestic sheep; 1:1000; fig 4
Ophelders D, Gussenhoven R, Lammens M, Küsters B, Kemp M, Newnham J, et al. Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure. J Neuroinflammation. 2016;13:29 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; fig 1
Eckharter C, Junker N, Winter L, Fischer I, Fogli B, Kistner S, et al. Schwann Cell Expressed Nogo-B Modulates Axonal Branching of Adult Sensory Neurons Through the Nogo-B Receptor NgBR. Front Cell Neurosci. 2015;9:454 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:1000; loading ...; fig 1e
Musolino P, Gong Y, Snyder J, Jiménez S, Lok J, Lo E, et al. Brain endothelial dysfunction in cerebral adrenoleukodystrophy. Brain. 2015;138:3206-20 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; fig 4
Cardoso F, Herz J, Fernandes A, Rocha J, Sepodes B, Brito M, et al. Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects. J Neuroinflammation. 2015;12:82 pubmed publisher
  • immunohistochemistry; rat; 1:200
Hattori T, Sato Y, Kondo T, Ichinohashi Y, Sugiyama Y, Yamamoto M, et al. Administration of umbilical cord blood cells transiently decreased hypoxic-ischemic brain injury in neonatal rats. Dev Neurosci. 2015;37:95-104 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:400; fig 1
Haines J, Herbin O, de la Hera B, Vidaurre O, Moy G, Sun Q, et al. Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination. Nat Neurosci. 2015;18:511-20 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig s1c
Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido T, et al. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. EMBO Mol Med. 2015;7:175-89 pubmed publisher
  • immunocytochemistry; mouse
Chang K, Zollinger D, Susuki K, Sherman D, Makara M, Brophy P, et al. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat Neurosci. 2014;17:1673-81 pubmed publisher
  • immunocytochemistry; rat; 1:200
  • western blot; rat; 1:500
Zhang J, Sun X, Zheng S, Liu X, Jin J, Ren Y, et al. Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane. PLoS ONE. 2014;9:e108646 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
de Bock L, Somers K, Fraussen J, Hendriks J, van Horssen J, Rouwette M, et al. Sperm-associated antigen 16 is a novel target of the humoral autoimmune response in multiple sclerosis. J Immunol. 2014;193:2147-56 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Bull S, Bin J, Beaumont E, Boutet A, Krimpenfort P, Sadikot A, et al. Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes. J Neurosci. 2014;34:9768-78 pubmed publisher
  • immunohistochemistry; mouse; 1:500
Lodato S, Molyneaux B, Zuccaro E, Goff L, Chen H, Yuan W, et al. Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014;17:1046-54 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500
  • western blot; mouse; 1:500
Faroni A, Smith R, Procacci P, Castelnovo L, Puccianti E, Reid A, et al. Purinergic signaling mediated by P2X7 receptors controls myelination in sciatic nerves. J Neurosci Res. 2014;92:1259-69 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:1000
Moore S, Khalaj A, Yoon J, Patel R, Hannsun G, Yoo T, et al. Therapeutic laquinimod treatment decreases inflammation, initiates axon remyelination, and improves motor deficit in a mouse model of multiple sclerosis. Brain Behav. 2013;3:664-82 pubmed publisher
  • immunohistochemistry; human
Luo S, Perry G, Levinson S, Henry M. Nav1.7 expression is increased in painful human dental pulp. Mol Pain. 2008;4:16 pubmed publisher
  • immunohistochemistry; rat; 1:100
Schneider S, Walker T. Morphology and electrophysiological properties of hamster spinal dorsal horn neurons that express VGLUT2 and enkephalin. J Comp Neurol. 2007;501:790-809 pubmed
Rice J, Coutellier L, Weiner J, Gu C. Region-specific interneuron demyelination and heightened anxiety-like behavior induced by adolescent binge alcohol treatment. Acta Neuropathol Commun. 2019;7:173 pubmed publisher
Tripathi A, Volsko C, Garcia J, Agirre E, Allan K, Tesar P, et al. Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination. Cell Rep. 2019;29:904-919.e9 pubmed publisher
Kim D, An H, Shearer R, Sharif M, Fan C, Choi J, et al. A principled strategy for mapping enhancers to genes. Sci Rep. 2019;9:11043 pubmed publisher
Qin C, Liu Q, Hu Z, Zhou L, Shang K, Bosco D, et al. Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway. Theranostics. 2018;8:5434-5451 pubmed publisher
Robinson D, Mammel A, Logan A, Larson A, Schmidt E, Condon A, et al. An In Vitro Model of Charcot-Marie-Tooth Disease Type 4B2 Provides Insight Into the Roles of MTMR13 and MTMR2 in Schwann Cell Myelination. ASN Neuro. 2018;10:1759091418803282 pubmed publisher
Wang X, Li R, Zacharek A, Landschoot Ward J, Wang F, Wu K, et al. Administration of Downstream ApoE Attenuates the Adverse Effect of Brain ABCA1 Deficiency on Stroke. Int J Mol Sci. 2018;19: pubmed publisher
Lee J, Lee J, Kahng J, Kim S, Park J, Yoon S, et al. Human glioblastoma arises from subventricular zone cells with low-level driver mutations. Nature. 2018;560:243-247 pubmed publisher
Fletcher J, Wood R, Nguyen J, Norman E, Jun C, Prawdiuk A, et al. Targeting TrkB with a Brain-Derived Neurotrophic Factor Mimetic Promotes Myelin Repair in the Brain. J Neurosci. 2018;38:7088-7099 pubmed publisher
Gold E, Vasilevko V, Hasselmann J, Tiefenthaler C, Hoa D, Ranawaka K, et al. Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral Deficits. ASN Neuro. 2018;10:1759091418781921 pubmed publisher
Srivastava T, Diba P, Dean J, Banine F, Shaver D, Hagen M, et al. A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors. J Clin Invest. 2018;128:2025-2041 pubmed publisher
Mitew S, Gobius I, Fenlon L, McDougall S, Hawkes D, Xing Y, et al. Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner. Nat Commun. 2018;9:306 pubmed publisher
Yoon H, Radulovic M, Walters G, Paulsen A, Drucker K, Starski P, et al. Protease activated receptor 2 controls myelin development, resiliency and repair. Glia. 2017;65:2070-2086 pubmed publisher
Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw A, et al. Astrocytic tight junctions control inflammatory CNS lesion pathogenesis. J Clin Invest. 2017;127:3136-3151 pubmed publisher
Wan G, Corfas G. Transient auditory nerve demyelination as a new mechanism for hidden hearing loss. Nat Commun. 2017;8:14487 pubmed publisher
Kim D, Choi J, Fan C, Shearer R, Sharif M, Busch P, et al. Homo-trimerization is essential for the transcription factor function of Myrf for oligodendrocyte differentiation. Nucleic Acids Res. 2017;45:5112-5125 pubmed publisher
Amor V, Zhang C, Vainshtein A, Zhang A, Zollinger D, Eshed Eisenbach Y, et al. The paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier. elife. 2017;6: pubmed publisher
Choi C, Yoo K, Hussaini S, Jeon B, WELBY J, Gan H, et al. The progeroid gene BubR1 regulates axon myelination and motor function. Aging (Albany NY). 2016;8:2667-2688 pubmed publisher
Bolino A, Piguet F, Alberizzi V, Pellegatta M, Rivellini C, Guerrero Valero M, et al. Niacin-mediated Tace activation ameliorates CMT neuropathies with focal hypermyelination. EMBO Mol Med. 2016;8:1438-1454 pubmed publisher
Goudarzi S, Rivera A, Butt A, Hafizi S. Gas6 Promotes Oligodendrogenesis and Myelination in the Adult Central Nervous System and After Lysolecithin-Induced Demyelination. ASN Neuro. 2016;8: pubmed publisher
Micheva K, Wolman D, Mensh B, Pax E, Buchanan J, Smith S, et al. A large fraction of neocortical myelin ensheathes axons of local inhibitory neurons. elife. 2016;5: pubmed publisher
Aojula A, Botfield H, MCALLISTER J, Gonzalez A, Abdullah O, Logan A, et al. Diffusion tensor imaging with direct cytopathological validation: characterisation of decorin treatment in experimental juvenile communicating hydrocephalus. Fluids Barriers CNS. 2016;13:9 pubmed publisher
Kuai X, Ni R, Zhou G, Mao Z, Zhang J, Yi N, et al. Transplantation of mouse embryonic stem cell-derived oligodendrocytes in the murine model of globoid cell leukodystrophy. Stem Cell Res Ther. 2015;6:30 pubmed publisher
Zenker J, Stettner M, Ruskamo S, Domènech Estévez E, Baloui H, Medard J, et al. A role of peripheral myelin protein 2 in lipid homeostasis of myelinating Schwann cells. Glia. 2014;62:1502-12 pubmed publisher
Kuypers E, Jellema R, Ophelders D, Dudink J, Nikiforou M, Wolfs T, et al. Effects of intra-amniotic lipopolysaccharide and maternal betamethasone on brain inflammation in fetal sheep. PLoS ONE. 2013;8:e81644 pubmed publisher
Belugin S, Diogenes A, Patil M, Ginsburg E, Henry M, Akopian A. Mechanisms of transient signaling via short and long prolactin receptor isoforms in female and male sensory neurons. J Biol Chem. 2013;288:34943-55 pubmed publisher
Wu J, Peng D, Voehler M, Sanders C, Li J. Structure and expression of a novel compact myelin protein - small VCP-interacting protein (SVIP). Biochem Biophys Res Commun. 2013;440:173-8 pubmed publisher
Burda J, Radulovic M, Yoon H, Scarisbrick I. Critical role for PAR1 in kallikrein 6-mediated oligodendrogliopathy. Glia. 2013;61:1456-70 pubmed publisher
Manninen O, Koskenkorva P, Lehtimäki K, Hyppönen J, Kononen M, Laitinen T, et al. White matter degeneration with Unverricht-Lundborg progressive myoclonus epilepsy: a translational diffusion-tensor imaging study in patients and cystatin B-deficient mice. Radiology. 2013;269:232-9 pubmed publisher
Abs E, Goorden S, Schreiber J, Overwater I, Hoogeveen Westerveld M, Bruinsma C, et al. TORC1-dependent epilepsy caused by acute biallelic Tsc1 deletion in adult mice. Ann Neurol. 2013;74:569-79 pubmed publisher
Buffington S, Rasband M. Na+ channel-dependent recruitment of Nav?4 to axon initial segments and nodes of Ranvier. J Neurosci. 2013;33:6191-202 pubmed publisher
Wyss L, Schäfer J, Liebner S, Mittelbronn M, Deutsch U, Enzmann G, et al. Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus. PLoS ONE. 2012;7:e45619 pubmed publisher
Koenning M, Jackson S, Hay C, Faux C, Kilpatrick T, Willingham M, et al. Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS. J Neurosci. 2012;32:12528-42 pubmed publisher
Kinter J, Lazzati T, Schmid D, Zeis T, Erne B, Lützelschwab R, et al. An essential role of MAG in mediating axon-myelin attachment in Charcot-Marie-Tooth 1A disease. Neurobiol Dis. 2013;49:221-31 pubmed publisher
McKee K, Yang D, Patel R, Chen Z, Strickland S, Takagi J, et al. Schwann cell myelination requires integration of laminin activities. J Cell Sci. 2012;125:4609-19 pubmed publisher
English J, Manadas B, Scaife C, Cotter D, Dunn M. Partitioning the proteome: phase separation for targeted analysis of membrane proteins in human post-mortem brain. PLoS ONE. 2012;7:e39509 pubmed publisher
Zenker J, Poirot O, de Preux Charles A, Arnaud E, Medard J, Lacroix C, et al. Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus. J Neurosci. 2012;32:7493-8 pubmed publisher
Gasser A, Ho T, Cheng X, Chang K, Waxman S, Rasband M, et al. An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier. J Neurosci. 2012;32:7232-43 pubmed publisher
Sato A, Ohtaki H, Tsumuraya T, Song D, Ohara K, Asano M, et al. Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury. J Neuroinflammation. 2012;9:65 pubmed publisher
Henry M, Luo S, Levinson S. Unmyelinated nerve fibers in the human dental pulp express markers for myelinated fibers and show sodium channel accumulations. BMC Neurosci. 2012;13:29 pubmed publisher
Scarisbrick I, Yoon H, Panos M, Larson N, Blaber S, Blaber M, et al. Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis. Brain Pathol. 2012;22:709-22 pubmed publisher
Reinisch C, Tschachler E. The dimensions and characteristics of the subepidermal nerve plexus in human skin--terminal Schwann cells constitute a substantial cell population within the superficial dermis. J Dermatol Sci. 2012;65:162-9 pubmed publisher
Schmiedt M, Blom T, Blom T, Kopra O, Wong A, von Schantz Fant C, et al. Cln5-deficiency in mice leads to microglial activation, defective myelination and changes in lipid metabolism. Neurobiol Dis. 2012;46:19-29 pubmed publisher
Jaarsma D, van der Pluijm I, de Waard M, Haasdijk E, Brandt R, Vermeij M, et al. Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology. PLoS Genet. 2011;7:e1002405 pubmed publisher
Reimer M, McQueen J, Searcy L, Scullion G, Zonta B, Desmazieres A, et al. Rapid disruption of axon-glial integrity in response to mild cerebral hypoperfusion. J Neurosci. 2011;31:18185-94 pubmed publisher
Kiebish M, Young D, Lehman J, Han X. Chronic caloric restriction attenuates a loss of sulfatide content in PGC-1?-/- mouse cortex: a potential lipidomic role of PGC-1? in neurodegeneration. J Lipid Res. 2012;53:273-81 pubmed publisher
Kuronen M, Hermansson M, Manninen O, Zech I, Talvitie M, Laitinen T, et al. Galactolipid deficiency in the early pathogenesis of neuronal ceroid lipofuscinosis model Cln8mnd : implications to delayed myelination and oligodendrocyte maturation. Neuropathol Appl Neurobiol. 2012;38:471-86 pubmed publisher
Duflocq A, Chareyre F, Giovannini M, Couraud F, Davenne M. Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B. BMC Biol. 2011;9:66 pubmed publisher
Homma S, Beermann M, Miller J. Peripheral nerve pathology, including aberrant Schwann cell differentiation, is ameliorated by doxycycline in a laminin-?2-deficient mouse model of congenital muscular dystrophy. Hum Mol Genet. 2011;20:2662-72 pubmed publisher
Ripoll C, Flaat M, Klopf Eiermann J, Fisher Perkins J, Trygg C, Scruggs B, et al. Mesenchymal lineage stem cells have pronounced anti-inflammatory effects in the twitcher mouse model of Krabbe's disease. Stem Cells. 2011;29:67-77 pubmed publisher
Jung K, Kim D, Lee H, Lee Y, Lee S, Che J, et al. The role of endothelin receptor A during myelination of developing oligodendrocytes. J Korean Med Sci. 2011;26:92-9 pubmed publisher
Sodersten E, Lilja T, Hermanson O. The novel BTB/POZ and zinc finger factor Zbtb45 is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. Cell Cycle. 2010;9:4866-75 pubmed
Kunz N, Camm E, Somm E, Lodygensky G, Darbre S, Aubert M, et al. Developmental and metabolic brain alterations in rats exposed to bisphenol A during gestation and lactation. Int J Dev Neurosci. 2011;29:37-43 pubmed publisher
Mierzwa A, Arevalo J, Schiff R, Chao M, Rosenbluth J. Role of transverse bands in maintaining paranodal structure and axolemmal domain organization in myelinated nerve fibers: effect on longevity in dysmyelinated mutant mice. J Comp Neurol. 2010;518:2841-53 pubmed publisher
Okun E, Griffioen K, Son T, Lee J, Roberts N, Mughal M, et al. TLR2 activation inhibits embryonic neural progenitor cell proliferation. J Neurochem. 2010;114:462-74 pubmed publisher
Henry M, Luo S, Foley B, Rzasa R, Johnson L, Levinson S. Sodium channel expression and localization at demyelinated sites in painful human dental pulp. J Pain. 2009;10:750-8 pubmed publisher
Nobbio L, Sturla L, Fiorese F, Usai C, Basile G, Moreschi I, et al. P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy. J Biol Chem. 2009;284:23146-58 pubmed publisher
Buser A, Schmid D, Kern F, Erne B, Lazzati T, Schaeren Wiemers N. The myelin protein MAL affects peripheral nerve myelination: a new player influencing p75 neurotrophin receptor expression. Eur J Neurosci. 2009;29:2276-90 pubmed publisher
Fatemi S, Folsom T, Reutiman T, Abu Odeh D, Mori S, Huang H, et al. Abnormal expression of myelination genes and alterations in white matter fractional anisotropy following prenatal viral influenza infection at E16 in mice. Schizophr Res. 2009;112:46-53 pubmed publisher
Stalder A, Erne B, Reimann R, Renaud S, Fuhr P, Thomann S, et al. Immunoglobulin M deposition in cutaneous nerves of anti-myelin-associated glycoprotein polyneuropathy patients correlates with axonal degeneration. J Neuropathol Exp Neurol. 2009;68:148-58 pubmed publisher
Antonow Schlorke I, Helgert A, Gey C, Coksaygan T, Schubert H, Nathanielsz P, et al. Adverse effects of antenatal glucocorticoids on cerebral myelination in sheep. Obstet Gynecol. 2009;113:142-51 pubmed publisher
Buser A, Erne B, Werner H, Nave K, Schaeren Wiemers N. The septin cytoskeleton in myelinating glia. Mol Cell Neurosci. 2009;40:156-66 pubmed publisher
Jarjour A, Bull S, Almasieh M, Rajasekharan S, Baker K, Mui J, et al. Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1. J Neurosci. 2008;28:11003-14 pubmed publisher
Wu J, Ohlsson M, Warner E, Loo K, Hoang T, Voskuhl R, et al. Glial reactions and degeneration of myelinated processes in spinal cord gray matter in chronic experimental autoimmune encephalomyelitis. Neuroscience. 2008;156:586-96 pubmed publisher
Felitsyn N, McLeod C, Shroads A, Stacpoole P, Notterpek L. The heme precursor delta-aminolevulinate blocks peripheral myelin formation. J Neurochem. 2008;106:2068-79 pubmed publisher
Zeis T, Graumann U, Reynolds R, Schaeren Wiemers N. Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection. Brain. 2008;131:288-303 pubmed
Homma S, Jin X, Wang G, Tu N, Min J, Yanasak N, et al. Demyelination, astrogliosis, and accumulation of ubiquitinated proteins, hallmarks of CNS disease in hsf1-deficient mice. J Neurosci. 2007;27:7974-86 pubmed
Nishi R, Liu H, Chu Y, Hamamura M, Su M, Nalcioglu O, et al. Behavioral, histological, and ex vivo magnetic resonance imaging assessment of graded contusion spinal cord injury in mice. J Neurotrauma. 2007;24:674-89 pubmed
Francis J, Olariu A, Kobayashi E, Leone P. GFP-transgenic Lewis rats as a cell source for oligodendrocyte replacement. Exp Neurol. 2007;205:177-89 pubmed
Blakqori G, Delhaye S, Habjan M, Blair C, S nchez Vargas I, Olson K, et al. La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts. J Virol. 2007;81:4991-9 pubmed publisher
Croitoru Lamoury J, Williams K, Lamoury F, Veas L, Ajami B, Taylor R, et al. Neural transplantation of human MSC and NT2 cells in the twitcher mouse model. Cytotherapy. 2006;8:445-58 pubmed
Li J, Bai Y, Ianakova E, Grandis M, Uchwat F, Trostinskaia A, et al. Major myelin protein gene (P0) mutation causes a novel form of axonal degeneration. J Comp Neurol. 2006;498:252-65 pubmed
Roth A, Ramírez G, Alarcón R, von Bernhardi R. Oligodendrocytes damage in Alzheimer's disease: beta amyloid toxicity and inflammation. Biol Res. 2005;38:381-7 pubmed
Chen J, Bernreuther C, Dihné M, Schachner M. Cell adhesion molecule l1-transfected embryonic stem cells with enhanced survival support regrowth of corticospinal tract axons in mice after spinal cord injury. J Neurotrauma. 2005;22:896-906 pubmed
product information
Catalog Number :
MAB386
Subcategory :
Neuroscience
Product Name :
Anti-Myelin Basic Protein Antibody, a.a. 82-87
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P02686
Host Name :
Rat
Antigen :
Myelin Basic Protein
Clone :
12
Conjugate :
Ascites
Isotype :
IgG2a
Product Description :
Anti-Myelin Basic Protein Antibody, a.a. 82-87
Cross Reactivity :
Bovine;Chicken;Guinea Pig;Human;Mouse;Rat;Sheep;Rabbit
Background :
The two major components of CNS myelin are Myelin Basic Protein (MBP) and proteolipid protein (PLP), occuring in roughly equimolar proportions. There are many neurological disorders associated with deficiencies of myelin assembly and structure. For example Multiple Sclerosis is a human disease due to multiple factors but generally characterized by the degradation of the myelin sheath. MBP ususally refers to the 18.5 kDa isoform, which is one of the most abundant proteins of the myelin sheath of adult human and bovine CNS. Genetically, MBP is the product of differential splicing of a single mRNA transcript. In humans there are 4 isoforms, 21.5, 20.2, 18.5, and 17.2 kDa. Thus, MBP are present in multiple isoforms, part of a large family of developmentally expressed, translocatable, and highly post-translationally modifed proteins with multiple binding partners. Structurally, MBP displays a predominately unorganized form with greater than 75% in random coil. Other non-CNS related functions of myelin include insulin induction and glucagon release from pancreatic islets.
ALT Names :
MBP
Immunogen :
Bovine myelin basic protein
Specificity :
Reacts with MBP from all species tested. It reacts weakly with peptides ending in the phe 91 where the 91-92 phe-phe bond is broken. Synthetic peptide 82-99 reacts very well as does intact MBP. Mapped to the region DENPVV.
Package Size :
1 mL
Uses :
ELISA;Immunocytochemistry;Immunohistochemistry;Radioimmunoassay;Western Blotting
Storage :
Stable for 1 year at -20ºC from date of receipt.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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