Tissue Transglutaminase Antibody, FN binding domain, clone 4G3 | EMD Millipore MAB3839 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tissue Transglutaminase Antibody, FN binding domain, clone 4G3

catalog :

MAB3839

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4G3

The same clone is also sold as:

Santa Cruz Biotechnology: sc-73612 L, sc-73612

reactivity :

human

application :

western blot, immunocytochemistry

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human	Fisher M, Keillor J, Xu W, Eckert R, Kerr C. Transglutaminase Is Required for Epidermal Squamous Cell Carcinoma Stem Cell Survival. Mol Cancer Res. 2015;13:1083-94 pubmed publisher
	Adhikary G, Grun D, Alexander H, Friedberg J, Xu W, Keillor J, et al. Transglutaminase is a mesothelioma cancer stem cell survival protein that is required for tumor formation. Oncotarget. 2018;9:34495-34505 pubmed publisher
	Kerr C, Szmacinski H, Fisher M, Nance B, Lakowicz J, Akbar A, et al. Transamidase site-targeted agents alter the conformation of the transglutaminase cancer stem cell survival protein to reduce GTP binding activity and cancer stem cell survival. Oncogene. 2017;36:2981-2990 pubmed publisher

product information

Catalog Number :

MAB3839

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Tissue Transglutaminase Antibody, FN binding domain, clone 4G3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P21980

Host Name :

Mouse

Antigen :

Tissue Transglutaminase

Clone :

4G3

Conjugate :

Purified

Product Description :

Anti-Tissue Transglutaminase Antibody, FN binding domain, clone 4G3

Cross Reactivity :

Human

Background :

Tissue transglutaminase (tTG) is a 75 kDa monomeric globular protein expressed in the majority of cells and tissues. tTG localizes mainly in the cytoplasm but some tGT is present on the cell surface and is association with the extracellular matrix. In addition to its guanosine triphosphatase (GTPase) activity, tTG catalyzes the posttranslational modification of proteins by transamidation of available glutamine residues (Monsonego, 1997). Extracellular tTG is able to bind to and cross-link several ECM proteins and may function to stabilize the ECM and basement membranes. The protein is translated as a fully active enzyme and there is no evidence for proteolytic activation. High constitutive expression and accumulation of active tTG is observed in (among others) endothelial cells, platelets, vascular smooth muscle cells and epithelial cells of the lens. tTG is expressed at very low levels in skeletal muscle cells and neurons and may be difficult to detect in these cell/tissue types.

ALT Names :

tTG; Protein-glutamine gamma-Glutamyltransferase; Transglutaminase 2; TGase C

Immunogen :

Fibronectin binding domain of tissue transglutaminase (amino acids 1-165 of tTG).

Specificity :

Tissue Transglutaminase. Will recognize all three known splice variants of tTG.

Package Size :

100 µg

Uses :

Immunocytochemistry

Storage :

Maintain at 2-8°C in undiluted aliquots for up to 12 months.