LEF-1 Antibody, β catenin binding domain, clone REMB1 | EMD Millipore MAB3751 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

LEF-1 Antibody, β catenin binding domain, clone REMB1

catalog :

MAB3751

quantity :

250 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

REMB1

The same clone is also sold as:

Agrisera: AS16 3997
OriGene: AM05260PU-L
Santa Cruz Biotechnology: sc-56722
LifeSpan Biosciences: LS-C140465
Invitrogen: MA1-12417, MA1-12418
Abnova: MAB1943

reactivity :

human

application :

western blot, immunocytochemistry

product information

Catalog Number :

MAB3751

Subcategory :

Stem Cell Research

Product Name :

Anti-LEF-1 Antibody, β catenin binding domain, clone REMB1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9UJU2

Host Name :

Mouse

Antigen :

LEF-1

Clone :

REMB1

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-LEF-1 Antibody, β catenin binding domain, clone REMB1

Cross Reactivity :

Human;Mouse

Background :

Lymphoid Enhancer Factor -1 is a transcription factor of the High Mobility Group of DNA binding proteins. It is one member of a family of four proteins referred to as LEF/TCF transcription factors (LEF-1, TCF-1, TCF-3 and TCF-4). These factors play a crucial role in WNT/Wingless signaling, a signal transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also a root cause in the genesis of certain cancers such as colon cancer, melanoma and breast cancer.LEF-1 is expressed during development in many different differentiating tissues, and in a few tissues after birth. LEF-1 expression is required for proper development of breast, teeth, hair, whiskers and the trigeminal nerve. It is redundant with TCF-1 (for T Cell Factor-1) for correct development of T lymphocytes in the thymus. LEF-1 is a 399 amino acid protein that appears as a cluster of [polypeptides ranging in size between 55-57 kDa on SDS-PAGE analysis. Alternative splice forms of LEF-1 and other LEF/TCF family members have been identified, but the expression pattern and relative abundance of these alternative forms have not been well studied. They can appear on westerns as smaller immunoreactive forms. Clone REMB1 recognizes the b-catenin binding domain of LEF-1.

ALT Names :

Lymphoid Enhancer Factor 1

Immunogen :

The immunogen for the anti-LEF-1 antibody was a full length protein. Does not cross-react with TCF-1 or TCF-4.

Specificity :

Recognizes the b-catenin binding domain of LEF-1(Lymphoid Enhancer Factor-1).

Package Size :

250 µg

Uses :

Immunofluorescence;Western Blotting

Storage :

Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.