LEF-1 Antibody, all isoforms, clone 1C3.1D10 | EMD Millipore MAB3750 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

LEF-1 Antibody, all isoforms, clone 1C3.1D10

catalog :

MAB3750

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1C3.1D10

The same clone is also sold as:

OriGene: AM05276PU-N
Invitrogen: MA1-12488

reactivity :

human

application :

western blot

product information

Catalog Number :

MAB3750

Subcategory :

Stem Cell Research

Product Name :

Anti-LEF-1 Antibody, all isoforms, clone 1C3.1D10

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9UJU2

Host Name :

Mouse

Antigen :

LEF-1

Clone :

1C3.1D10

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-LEF-1 Antibody, all isoforms, clone 1C3.1D10

Cross Reactivity :

Human

Background :

Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF-4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others. This antibody recognizes an epitope in amino acids 256-308 of LEF-1. This region is between the transactivation domain and the HMG binding domain of LEF-1 and is conserved in all LEF-1 isoforms.

ALT Names :

Lymphoid Enhancer Factor 1

Immunogen :

Recombinant full length LEF-1 protein.

Specificity :

Recognizes human LEF-1 (Lymphoid Enhancer Factor-1) protein. Does not cross-react with TCF-1 or TCF-4.

Package Size :

100 µg

Uses :

Western Blotting

Storage :

Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.