| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunocytochemistry; human; loading ...; fig 5
- western blot; human; loading ...; fig 4a
| Wu X, Kosaraju J, Tam K. SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3? activity in SH-SY5Y cells. Eur J Pharm Sci. 2017;110:101-108 pubmed publisher |
- western blot; mouse; 1:2500; loading ...; fig 4a
| He X, Li Z, Rizak J, Wu S, Wang Z, He R, et al. Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells. Front Neurosci. 2016;10:598 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 1b
| Bodea L, Evans H, Van der Jeugd A, Ittner L, Delerue F, Kril J, et al. Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell. 2017;16:377-386 pubmed publisher |
- immunohistochemistry; human; 1:100; loading ...; fig 4b
| Augé E, Cabezón I, Pelegri C, Vilaplana J. New perspectives on corpora amylacea in the human brain. Sci Rep. 2017;7:41807 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5c
| Wang A, Jensen E, Rexach J, Vinters H, Hsieh Wilson L. Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration. Proc Natl Acad Sci U S A. 2016;113:15120-15125 pubmed publisher |
- western blot; mouse; 1:500; fig 6
| Herring A, Münster Y, Akkaya T, Moghaddam S, Deinsberger K, Meyer J, et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement. 2016;12:1273-1287 pubmed publisher |
- western blot; mouse; 1:1000; fig 2
| Polanco J, Scicluna B, Hill A, Götz J. Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner. J Biol Chem. 2016;291:12445-66 pubmed publisher |
- western blot; human; 1:1000; fig 4
| Patzke C, Acuna C, Giam L, Wernig M, Südhof T. Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation. J Exp Med. 2016;213:499-515 pubmed publisher |
- western blot; human; 1:2000; fig 1
- western blot; mouse; 1:2000; fig 1
| Gurdziel K, Vogt K, Walton K, Schneider G, Gumucio D. Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016;245:614-26 pubmed publisher |
- western blot; mouse; fig 2
| Watamura N, Toba J, Yoshii A, Nikkuni M, Ohshima T. Colocalization of phosphorylated forms of WAVE1, CRMP2, and tau in Alzheimer's disease model mice: Involvement of Cdk5 phosphorylation and the effect of ATRA treatment. J Neurosci Res. 2016;94:15-26 pubmed publisher |
- immunocytochemistry; rat; 1:500
| Zajkowski T, Nieznanska H, Nieznanski K. Stabilization of microtubular cytoskeleton protects neurons from toxicity of N-terminal fragment of cytosolic prion protein. Biochim Biophys Acta. 2015;1853:2228-39 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:1000
- immunoprecipitation; mouse; 1:1000
| Pei L, Wang S, Jin H, Bi L, Wei N, Yan H, et al. A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau. Cereb Cortex. 2015;25:4559-71 pubmed publisher |
- western blot; mouse; 1:1000
| Sabogal Guáqueta A, Muñoz Manco J, RamÃrez Pineda J, Lamprea Rodriguez M, Osorio E, Cardona Gómez G. The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice. Neuropharmacology. 2015;93:134-45 pubmed publisher |
- western blot; mouse; fig 6
| Lee S, Sharma M, S dhof T, Shen J. Synaptic function of nicastrin in hippocampal neurons. Proc Natl Acad Sci U S A. 2014;111:8973-8 pubmed publisher |
- immunohistochemistry - frozen section; mouse
| Manich G, del Valle J, Cabezón I, Camins A, Pallas M, Pelegri C, et al. Presence of a neo-epitope and absence of amyloid beta and tau protein in degenerative hippocampal granules of aged mice. Age (Dordr). 2014;36:151-65 pubmed publisher |
| Boselli M, Lee B, Robert J, Prado M, Min S, Cheng C, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem. 2017;292:19209-19225 pubmed publisher |
| Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed publisher |
| Sepúlveda Díaz J, Alavi Naini S, Huynh M, Ouidja M, Yanicostas C, Chantepie S, et al. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology. Brain. 2015;138:1339-54 pubmed publisher |
| Shang X, Wang Q, Liu X, Yao X, Cao F, Wang Q, et al. Fluorocitrate induced the alterations of memory-related proteins and tau hyperphosphorylation in SD rats. Neurosci Lett. 2015;584:230-5 pubmed publisher |
| Oyanagi K, Negishi T, Tashiro T. Action of thyroxine on the survival and neurite maintenance of cerebellar granule neurons in culture. J Neurosci Res. 2015;93:592-603 pubmed publisher |
| Lv Q, Lan W, Sun W, Ye R, Fan X, Ma M, et al. Intranasal nerve growth factor attenuates tau phosphorylation in brain after traumatic brain injury in rats. J Neurol Sci. 2014;345:48-55 pubmed publisher |
| Wang D, Hui Y, Peng Y, Tang L, Jin J, He R, et al. Overexpression of heme oxygenase 1 causes cognitive decline and affects pathways for tauopathy in mice. J Alzheimers Dis. 2015;43:519-34 pubmed publisher |
| Gheyara A, Ponnusamy R, Djukic B, Craft R, Ho K, Guo W, et al. Tau reduction prevents disease in a mouse model of Dravet syndrome. Ann Neurol. 2014;76:443-56 pubmed publisher |
| Xia Y, Liu R, Chen R, Tian Q, Zeng K, Hu J, et al. Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats. J Alzheimers Dis. 2014;42:1029-39 pubmed publisher |
| Rao M, McBrayer M, Campbell J, Kumar A, Hashim A, Sershen H, et al. Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice. J Neurosci. 2014;34:9222-34 pubmed publisher |
| Saito R, Kaneko M, Kitamura Y, Takata K, Kawada K, Okuma Y, et al. Effects of oxidative stress on the solubility of HRD1, a ubiquitin ligase implicated in Alzheimer's disease. PLoS ONE. 2014;9:e94576 pubmed publisher |
| Liu X, Wang Z, Xia Y, Yu G, Zeng K, Luo H, et al. Losartan-induced hypotension leads to tau hyperphosphorylation and memory deficit. J Alzheimers Dis. 2014;40:419-27 pubmed publisher |
| Kimura T, Whitcomb D, Jo J, Regan P, Piers T, Heo S, et al. Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Philos Trans R Soc Lond B Biol Sci. 2014;369:20130144 pubmed publisher |
| Dong D, Zhang Y, Yang W, Wang Qin R, Xu A, Ruan Y. Hyperphosphorylation of tau protein in the ipsilateral thalamus after focal cortical infarction in rats. Brain Res. 2014;1543:280-9 pubmed publisher |
| Lu Y, He H, Zhou J, Miao J, Lu J, He Y, et al. Hyperphosphorylation results in tau dysfunction in DNA folding and protection. J Alzheimers Dis. 2013;37:551-63 pubmed publisher |
| Hong X, Bu L, Wang Y, Xu J, Wu J, Huang Y, et al. Increases in the risk of cognitive impairment and alterations of cerebral ?-amyloid metabolism in mouse model of heart failure. PLoS ONE. 2013;8:e63829 pubmed publisher |
| Basurto Islas G, Grundke Iqbal I, Tung Y, Liu F, Iqbal K. Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease. J Biol Chem. 2013;288:17495-507 pubmed publisher |
| Lu J, Miao J, Su T, Liu Y, He R. Formaldehyde induces hyperphosphorylation and polymerization of Tau protein both in vitro and in vivo. Biochim Biophys Acta. 2013;1830:4102-16 pubmed publisher |
| Park Y, Ko J, Jang Y, Kwon Y. Activation of AMP-activated protein kinase alleviates homocysteine-mediated neurotoxicity in SH-SY5Y cells. Neurochem Res. 2013;38:1561-71 pubmed publisher |
| Oaks A, Frankfurt M, Finkelstein D, Sidhu A. Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function. PLoS ONE. 2013;8:e60378 pubmed publisher |
| Lee S, Zhang W, Ravi M, Weschenfelder M, Bastmeyer M, Levine J. Atypical protein kinase C and Par3 are required for proteoglycan-induced axon growth inhibition. J Neurosci. 2013;33:2541-54 pubmed publisher |
| Yu G, Yan T, Feng Y, Liu X, Xia Y, Luo H, et al. Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease. Neurobiol Aging. 2013;34:1748-58 pubmed publisher |
| King M, Anderson N, Guernsey L, Jolivalt C. Glycogen synthase kinase-3 inhibition prevents learning deficits in diabetic mice. J Neurosci Res. 2013;91:506-14 pubmed publisher |
| Holth J, Bomben V, Reed J, Inoue T, Younkin L, Younkin S, et al. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. J Neurosci. 2013;33:1651-9 pubmed publisher |
| Li L, Liu Z, Liu J, Tai X, Hu X, Liu X, et al. Ginsenoside Rd attenuates beta-amyloid-induced tau phosphorylation by altering the functional balance of glycogen synthase kinase 3beta and protein phosphatase 2A. Neurobiol Dis. 2013;54:320-8 pubmed publisher |
| Marker D, Puccini J, Mockus T, Barbieri J, Lu S, Gelbard H. LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein. J Neuroinflammation. 2012;9:261 pubmed publisher |
| Sharma M, Burré J, Sudhof T. Proteasome inhibition alleviates SNARE-dependent neurodegeneration. Sci Transl Med. 2012;4:147ra113 pubmed publisher |
| Xiong Y, Jing X, Zhou X, Wang X, Yang Y, Sun X, et al. Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging. 2013;34:745-56 pubmed publisher |
| Larson M, Sherman M, Greimel S, Kuskowski M, Schneider J, Bennett D, et al. Soluble ?-synuclein is a novel modulator of Alzheimer's disease pathophysiology. J Neurosci. 2012;32:10253-66 pubmed publisher |
| Rachubinski A, Maclean K, Evans J, Bjugstad K. Modulating cognitive deficits and tau accumulation in a mouse model of aging Down syndrome through neonatal implantation of neural progenitor cells. Exp Gerontol. 2012;47:723-33 pubmed publisher |
| Hui L, Chen X, Geiger J. Endolysosome involvement in LDL cholesterol-induced Alzheimer's disease-like pathology in primary cultured neurons. Life Sci. 2012;91:1159-68 pubmed publisher |
| Wills J, Credle J, Oaks A, Duka V, Lee J, Jones J, et al. Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways. PLoS ONE. 2012;7:e30745 pubmed publisher |
| Alvarez G, Aldudo J, Alonso M, Santana S, Valdivieso F. Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cells. J Neurosci Res. 2012;90:1020-9 pubmed publisher |
| Li L, Liu J, Yan X, Qin K, Shi M, Lin T, et al. Protective effects of ginsenoside Rd against okadaic acid-induced neurotoxicity in vivo and in vitro. J Ethnopharmacol. 2011;138:135-41 pubmed publisher |
| Koechling T, Khalique H, Sundstrom E, Avila J, Lim F. A culture model for neurite regeneration of human spinal cord neurons. J Neurosci Methods. 2011;201:346-54 pubmed publisher |
| Yang X, Yang Y, Liu J, Li G, Yang E. Increased phosphorylation of tau and synaptic protein loss in the aged transgenic mice expressing familiar Alzheimer's disease-linked presenilin 1 mutation. Neurochem Res. 2012;37:15-22 pubmed publisher |
| Kaul T, Credle J, Haggerty T, Oaks A, Masliah E, Sidhu A. Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease. BMC Neurosci. 2011;12:79 pubmed publisher |
| Grueninger F, Bohrmann B, Christensen K, Graf M, Roth D, Czech C. Novel screening cascade identifies MKK4 as key kinase regulating Tau phosphorylation at Ser422. Mol Cell Biochem. 2011;357:199-207 pubmed publisher |
| Ploia C, Antoniou X, Sclip A, Grande V, Cardinetti D, Colombo A, et al. JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models. J Alzheimers Dis. 2011;26:315-29 pubmed publisher |
| Hui Y, Wang D, Li W, Zhang L, Jin J, Ma N, et al. Long-term overexpression of heme oxygenase 1 promotes tau aggregation in mouse brain by inducing tau phosphorylation. J Alzheimers Dis. 2011;26:299-313 pubmed publisher |
| Haggerty T, Credle J, Rodriguez O, Wills J, Oaks A, Masliah E, et al. Hyperphosphorylated Tau in an ?-synuclein-overexpressing transgenic model of Parkinson's disease. Eur J Neurosci. 2011;33:1598-610 pubmed publisher |
| Wills J, Credle J, Haggerty T, Lee J, Oaks A, Sidhu A. Tauopathic changes in the striatum of A53T ?-synuclein mutant mouse model of Parkinson's disease. PLoS ONE. 2011;6:e17953 pubmed publisher |
| Peethumnongsin E, Yang L, Kallhoff Munoz V, Hu L, Takashima A, Pautler R, et al. Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. J Neurosci. 2010;30:13409-18 pubmed publisher |
| Kern D, Maclean K, Jiang H, Synder E, Sladek J, Bjugstad K. Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice. Cell Transplant. 2011;20:371-9 pubmed publisher |
| Blanchard J, Wanka L, Tung Y, Cárdenas Aguayo M, LaFerla F, Iqbal K, et al. Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting A? and tau pathologies in 3xTg-AD mice. Acta Neuropathol. 2010;120:605-21 pubmed publisher |
| Saito M, Chakraborty G, Hegde M, Ohsie J, Paik S, Vadasz C, et al. Involvement of ceramide in ethanol-induced apoptotic neurodegeneration in the neonatal mouse brain. J Neurochem. 2010;115:168-77 pubmed publisher |
| Wills J, Jones J, Haggerty T, Duka V, Joyce J, Sidhu A. Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol. 2010;225:210-8 pubmed publisher |
| Saito M, Chakraborty G, Mao R, Paik S, Vadasz C, Saito M. Tau phosphorylation and cleavage in ethanol-induced neurodegeneration in the developing mouse brain. Neurochem Res. 2010;35:651-9 pubmed publisher |
| Kathleen Baxter K, Uittenbogaard M, Yoon J, Chiaramello A. The neurogenic basic helix-loop-helix transcription factor NeuroD6 concomitantly increases mitochondrial mass and regulates cytoskeletal organization in the early stages of neuronal differentiation. ASN Neuro. 2009;1: pubmed publisher |
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| Davis R, Furukawa R, Fechheimer M. A cell culture model for investigation of Hirano bodies. Acta Neuropathol. 2008;115:205-17 pubmed |
| Macleod D, Dowman J, Hammond R, Leete T, Inoue K, Abeliovich A. The familial Parkinsonism gene LRRK2 regulates neurite process morphology. Neuron. 2006;52:587-93 pubmed |
| Ghribi O, Larsen B, Schrag M, Herman M. High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus. Exp Neurol. 2006;200:460-7 pubmed |
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