Caspase 2 Antibody, clone 11B4 | EMD Millipore MAB3507 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Caspase 2 Antibody, clone 11B4

catalog :

MAB3507

quantity :

100 µg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

11B4

The same clone is also sold as:

Enzo Life Sciences: ALX-804-356-C100
Abnova: MAB3485
LifeSpan Biosciences: LS-C344950

reactivity :

human, mouse

application :

western blot, ELISA, immunoprecipitation, flow cytometry

citations: 11

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 2a	Ando K, PARSONS M, Shah R, Charendoff C, Paris S, Liu P, et al. NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. J Cell Biol. 2017;216:1795-1810 pubmed publisher
western blot; mouse	Sharma R, Callaway D, Vanegas D, Bendele M, Lopez Cruzan M, Horn D, et al. Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts. PLoS ONE. 2014;9:e93696 pubmed publisher
western blot; human	Del Nagro C, Choi J, Xiao Y, Rangell L, Mohan S, Pandita A, et al. Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death. Cell Cycle. 2014;13:303-14 pubmed publisher
western blot; mouse	Parsons M, McCormick L, Janke L, Howard A, Bouchier Hayes L, Green D. Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice. Cell Death Differ. 2013;20:1174-82 pubmed publisher
western blot; human; fig 7	Orzáez M, Guevara T, Sancho M, Perez Paya E. Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment. Cell Death Dis. 2012;3:e415 pubmed publisher
	Dorstyn L, Puccini J, Wilson C, Shalini S, Nicola M, Moore S, et al. Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability. Cell Death Differ. 2012;19:1288-98 pubmed publisher
	Shalini S, Dorstyn L, Wilson C, Puccini J, Ho L, Kumar S. Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice. Cell Death Differ. 2012;19:1370-80 pubmed publisher
	Pan J, Ullman E, Dou Z, Zong W. Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes. Mol Cell Biol. 2011;31:3158-70 pubmed publisher
	Ullman E, Pan J, Zong W. Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury. Mol Cell Biol. 2011;31:2902-19 pubmed publisher
	Myers K, Gagou M, Zuazua Villar P, Rodriguez R, Meuth M. ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress. PLoS Genet. 2009;5:e1000324 pubmed publisher
	Vande Walle L, Van Damme P, Lamkanfi M, Saelens X, Vandekerckhove J, Gevaert K, et al. Proteome-wide Identification of HtrA2/Omi Substrates. J Proteome Res. 2007;6:1006-15 pubmed

product information

Catalog Number :

MAB3507

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Caspase 2 Antibody, clone 11B4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P42575

Host Name :

Rat

Antigen :

Caspase 2

Clone :

11B4

Conjugate :

Purified

Isotype :

IgG2a

Product Description :

Anti-Caspase 2 Antibody, clone 11B4

Cross Reactivity :

Canine;Human;Mouse;Monkey

ALT Names :

ICH-1

Immunogen :

Raised against the P19 subunit of recombinant human Caspase-2 protein.

Specificity :

MAB3507 antibody recognizes a reactive epitope that lies in the P19 subunit of human Caspase-2 (ICH-1, Nedd-2).

Package Size :

100 µg

Uses :

ELISA;Flow Cytometry;Immunoprecipitation;Western Blotting

Storage :

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.