Published Application/Species/Sample/Dilution | Reference |
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- western blot; mouse; 1:500; loading ...; fig 5a
| Kazuki Y, Gao F, Li Y, Moyer A, Devenney B, Hiramatsu K, et al. A non-mosaic transchromosomic mouse model of down syndrome carrying the long arm of human chromosome 21. elife. 2020;9: pubmed publisher
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- western blot; mouse; loading ...; fig 5c
| Bruyère J, Abada Y, Vitet H, Fontaine G, Deloulme J, Ces A, et al. Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin. elife. 2020;9: pubmed publisher
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- western blot; human; 1:2000; loading ...; fig 5h
| Barros Viegas A, Carmona V, Ferreiro E, Guedes J, Cardoso A, Cunha P, et al. miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer's Disease. Mol Ther Nucleic Acids. 2020;19:1219-1236 pubmed publisher
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- western blot; mouse; loading ...; fig 3e
| Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed publisher
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- western blot; human; loading ...; fig 1a
| Jarosz Griffiths H, Corbett N, Rowland H, Fisher K, Jones A, Baron J, et al. Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers. J Biol Chem. 2019;294:7085-7097 pubmed publisher
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- western blot; mouse; 1:50; loading ...; fig 1b
| Tsatsanis A, Dickens S, Kwok J, Wong B, Duce J. Post Translational Modulation of β-Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis. Neurochem Res. 2019;44:1367-1374 pubmed publisher
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- western blot; human; loading ...; fig 2b
- western blot; mouse; loading ...; fig 1c
| Sun J, Carlson Stevermer J, Das U, Shen M, Delenclos M, Snead A, et al. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nat Commun. 2019;10:53 pubmed publisher
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- immunohistochemistry - paraffin section; mouse; loading ...; fig s7b
| Atretkhany K, Mufazalov I, Dunst J, Kuchmiy A, Gogoleva V, Andruszewski D, et al. Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity. Proc Natl Acad Sci U S A. 2018;115:13051-13056 pubmed publisher
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| Meilandt W, Maloney J, Imperio J, Lalehzadeh G, Earr T, Crowell S, et al. Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ. Alzheimers Res Ther. 2019;11:97 pubmed publisher
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| Tambini M, Yao W, D ADAMIO L. Facilitation of glutamate, but not GABA, release in Familial Alzheimer's APP mutant Knock-in rats with increased β-cleavage of APP. Aging Cell. 2019;18:e13033 pubmed publisher
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| Suh J, Romano D, Nitschke L, Herrick S, DiMarzio B, Dzhala V, et al. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 2019;178:1159-1175.e17 pubmed publisher
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| Manogaran P, Samardzija M, Schad A, Wicki C, Walker Egger C, Rudin M, et al. Retinal pathology in experimental optic neuritis is characterized by retrograde degeneration and gliosis. Acta Neuropathol Commun. 2019;7:116 pubmed publisher
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| Götzl J, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, et al. Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. EMBO Mol Med. 2019;: pubmed publisher
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| Grant M, Shapiro S, Ashe K, Liu P, Zahs K. A Cautionary Tale: Endogenous Biotinylated Proteins and Exogenously-Introduced Protein A Cause Antibody-Independent Artefacts in Western Blot Studies of Brain-Derived Proteins. Biol Proced Online. 2019;21:6 pubmed publisher
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| Bergner C, van der Meer F, Winkler A, Wrzos C, Türkmen M, Valizada E, et al. Microglia damage precedes major myelin breakdown in X-linked adrenoleukodystrophy and metachromatic leukodystrophy. Glia. 2019;67:1196-1209 pubmed publisher
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| Dinamarca M, Raveh A, Schneider A, Fritzius T, Früh S, Rem P, et al. Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing. Nat Commun. 2019;10:1331 pubmed publisher
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| Chen X, Kordich J, Williams E, Levine N, Cole Strauss A, Marshall L, et al. Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration. Proc Natl Acad Sci U S A. 2019;116:5765-5774 pubmed publisher
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| Li J, Chiu J, Pratico D. Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35. Mol Psychiatry. 2019;: pubmed publisher
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| Wimmer I, Scharler C, Zrzavy T, Kadowaki T, Mödlagl V, Rojc K, et al. Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis. Acta Neuropathol Commun. 2019;7:14 pubmed publisher
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| Evans C, Thomas R, Freeman T, Hvoslef Eide M, Good M, Kidd E. Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice. Neurobiol Aging. 2019;75:136-149 pubmed publisher
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| Tsang J, Lee M, Chan T, Li J, Ni Y, Shao Y, et al. Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer. EBioMedicine. 2018;38:89-99 pubmed publisher
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| Heisler F, Pechmann Y, Wieser I, Altmeppen H, Veenendaal L, Muhia M, et al. Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression. Neuron. 2018;99:1155-1169.e9 pubmed publisher
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| Paschkowsky S, Recinto S, Young J, Bondar A, Munter L. Membrane cholesterol as regulator of human rhomboid protease RHBDL4. J Biol Chem. 2018;293:15556-15568 pubmed publisher
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| Sasaguri H, Nagata K, Sekiguchi M, Fujioka R, Matsuba Y, Hashimoto S, et al. Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID. Nat Commun. 2018;9:2892 pubmed publisher
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| Sulkava S, Muggalla P, Sulkava R, Ollila H, Peuralinna T, Myllykangas L, et al. Melatonin receptor type 1A gene linked to Alzheimer's disease in old age. Sleep. 2018;41: pubmed publisher
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| Fong L, Yang M, Dos Santos Chaves R, Reyna S, Langness V, Woodruff G, et al. Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes. J Biol Chem. 2018;293:11341-11357 pubmed publisher
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| Nagata K, Takahashi M, Matsuba Y, Okuyama Uchimura F, Sato K, Hashimoto S, et al. Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathology. Nat Commun. 2018;9:1800 pubmed publisher
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| Ruiz Riquelme A, Lau H, Stuart E, Goczi A, Wang Z, Schmitt Ulms G, et al. Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression. Acta Neuropathol Commun. 2018;6:26 pubmed publisher
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| Chung J, Phukan G, Vergote D, Mohamed A, Maulik M, Stahn M, et al. Endosomal-Lysosomal Cholesterol Sequestration by U18666A Differentially Regulates Amyloid Precursor Protein (APP) Metabolism in Normal and APP-Overexpressing Cells. Mol Cell Biol. 2018;38: pubmed publisher
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| Rossi M, Saverioni D, Di Bari M, Baiardi S, Lemstra A, Pirisinu L, et al. Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature. Acta Neuropathol Commun. 2017;5:87 pubmed publisher
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| Lanchec E, Desilets A, Béliveau F, Flamier A, Mahmoud S, Bernier G, et al. The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β-amyloid peptide. J Biol Chem. 2017;292:20669-20682 pubmed publisher
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| Colvin B, Rogers V, Kulas J, Ridgway E, Amtashar F, Combs C, et al. The conformational epitope for a new A?42 protofibril-selective antibody partially overlaps with the peptide N-terminal region. J Neurochem. 2017;143:736-749 pubmed publisher
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| Mass E, Jacome Galarza C, Blank T, Lazarov T, Durham B, Ozkaya N, et al. A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease. Nature. 2017;549:389-393 pubmed publisher
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