This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
APP A4
catalog :
MAB348
clonality :
monoclonal
conjugate :
nonconjugated
clone name :
22C11

The same clone is also sold as:
reactivity :
human, mouse
application :
western blot, immunohistochemistry - paraffin section
citations: 47
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:500; loading ...; fig 5a
Kazuki Y, Gao F, Li Y, Moyer A, Devenney B, Hiramatsu K, et al. A non-mosaic transchromosomic mouse model of down syndrome carrying the long arm of human chromosome 21. elife. 2020;9: pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Bruyère J, Abada Y, Vitet H, Fontaine G, Deloulme J, Ces A, et al. Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin. elife. 2020;9: pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 5h
Barros Viegas A, Carmona V, Ferreiro E, Guedes J, Cardoso A, Cunha P, et al. miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer's Disease. Mol Ther Nucleic Acids. 2020;19:1219-1236 pubmed publisher
  • western blot; mouse; loading ...; fig 3e
Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed publisher
  • western blot; human; loading ...; fig 1a
Jarosz Griffiths H, Corbett N, Rowland H, Fisher K, Jones A, Baron J, et al. Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers. J Biol Chem. 2019;294:7085-7097 pubmed publisher
  • western blot; mouse; 1:50; loading ...; fig 1b
Tsatsanis A, Dickens S, Kwok J, Wong B, Duce J. Post Translational Modulation of β-Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis. Neurochem Res. 2019;44:1367-1374 pubmed publisher
  • western blot; human; loading ...; fig 2b
  • western blot; mouse; loading ...; fig 1c
Sun J, Carlson Stevermer J, Das U, Shen M, Delenclos M, Snead A, et al. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nat Commun. 2019;10:53 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s7b
Atretkhany K, Mufazalov I, Dunst J, Kuchmiy A, Gogoleva V, Andruszewski D, et al. Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity. Proc Natl Acad Sci U S A. 2018;115:13051-13056 pubmed publisher
Meilandt W, Maloney J, Imperio J, Lalehzadeh G, Earr T, Crowell S, et al. Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ. Alzheimers Res Ther. 2019;11:97 pubmed publisher
Tambini M, Yao W, D ADAMIO L. Facilitation of glutamate, but not GABA, release in Familial Alzheimer's APP mutant Knock-in rats with increased β-cleavage of APP. Aging Cell. 2019;18:e13033 pubmed publisher
Suh J, Romano D, Nitschke L, Herrick S, DiMarzio B, Dzhala V, et al. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 2019;178:1159-1175.e17 pubmed publisher
Manogaran P, Samardzija M, Schad A, Wicki C, Walker Egger C, Rudin M, et al. Retinal pathology in experimental optic neuritis is characterized by retrograde degeneration and gliosis. Acta Neuropathol Commun. 2019;7:116 pubmed publisher
Götzl J, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, et al. Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. EMBO Mol Med. 2019;: pubmed publisher
Grant M, Shapiro S, Ashe K, Liu P, Zahs K. A Cautionary Tale: Endogenous Biotinylated Proteins and Exogenously-Introduced Protein A Cause Antibody-Independent Artefacts in Western Blot Studies of Brain-Derived Proteins. Biol Proced Online. 2019;21:6 pubmed publisher
Bergner C, van der Meer F, Winkler A, Wrzos C, Türkmen M, Valizada E, et al. Microglia damage precedes major myelin breakdown in X-linked adrenoleukodystrophy and metachromatic leukodystrophy. Glia. 2019;67:1196-1209 pubmed publisher
Dinamarca M, Raveh A, Schneider A, Fritzius T, Früh S, Rem P, et al. Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing. Nat Commun. 2019;10:1331 pubmed publisher
Chen X, Kordich J, Williams E, Levine N, Cole Strauss A, Marshall L, et al. Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration. Proc Natl Acad Sci U S A. 2019;116:5765-5774 pubmed publisher
Li J, Chiu J, Pratico D. Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35. Mol Psychiatry. 2019;: pubmed publisher
Wimmer I, Scharler C, Zrzavy T, Kadowaki T, Mödlagl V, Rojc K, et al. Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis. Acta Neuropathol Commun. 2019;7:14 pubmed publisher
Evans C, Thomas R, Freeman T, Hvoslef Eide M, Good M, Kidd E. Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice. Neurobiol Aging. 2019;75:136-149 pubmed publisher
Tsang J, Lee M, Chan T, Li J, Ni Y, Shao Y, et al. Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer. EBioMedicine. 2018;38:89-99 pubmed publisher
Heisler F, Pechmann Y, Wieser I, Altmeppen H, Veenendaal L, Muhia M, et al. Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression. Neuron. 2018;99:1155-1169.e9 pubmed publisher
Paschkowsky S, Recinto S, Young J, Bondar A, Munter L. Membrane cholesterol as regulator of human rhomboid protease RHBDL4. J Biol Chem. 2018;293:15556-15568 pubmed publisher
Sasaguri H, Nagata K, Sekiguchi M, Fujioka R, Matsuba Y, Hashimoto S, et al. Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID. Nat Commun. 2018;9:2892 pubmed publisher
Sulkava S, Muggalla P, Sulkava R, Ollila H, Peuralinna T, Myllykangas L, et al. Melatonin receptor type 1A gene linked to Alzheimer's disease in old age. Sleep. 2018;41: pubmed publisher
Fong L, Yang M, Dos Santos Chaves R, Reyna S, Langness V, Woodruff G, et al. Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes. J Biol Chem. 2018;293:11341-11357 pubmed publisher
Nagata K, Takahashi M, Matsuba Y, Okuyama Uchimura F, Sato K, Hashimoto S, et al. Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathology. Nat Commun. 2018;9:1800 pubmed publisher
Ruiz Riquelme A, Lau H, Stuart E, Goczi A, Wang Z, Schmitt Ulms G, et al. Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression. Acta Neuropathol Commun. 2018;6:26 pubmed publisher
Chung J, Phukan G, Vergote D, Mohamed A, Maulik M, Stahn M, et al. Endosomal-Lysosomal Cholesterol Sequestration by U18666A Differentially Regulates Amyloid Precursor Protein (APP) Metabolism in Normal and APP-Overexpressing Cells. Mol Cell Biol. 2018;38: pubmed publisher
ULRICH J, Ulland T, Mahan T, Nyström S, Nilsson K, Song W, et al. ApoE facilitates the microglial response to amyloid plaque pathology. J Exp Med. 2018;215:1047-1058 pubmed publisher
Halon Golabek M, Borkowska A, Kaczor J, Ziolkowski W, Flis D, Knap N, et al. hmSOD1 gene mutation-induced disturbance in iron metabolism is mediated by impairment of Akt signalling pathway. J Cachexia Sarcopenia Muscle. 2018;9:557-569 pubmed publisher
Janova H, Arinrad S, Balmuth E, Mitjans M, Hertel J, Habes M, et al. Microglia ablation alleviates myelin-associated catatonic signs in mice. J Clin Invest. 2018;128:734-745 pubmed publisher
Rossi M, Saverioni D, Di Bari M, Baiardi S, Lemstra A, Pirisinu L, et al. Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature. Acta Neuropathol Commun. 2017;5:87 pubmed publisher
Lanchec E, Desilets A, Béliveau F, Flamier A, Mahmoud S, Bernier G, et al. The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β-amyloid peptide. J Biol Chem. 2017;292:20669-20682 pubmed publisher
Williamson R, Laulagnier K, Miranda A, Fernandez M, Wolfe M, Sadoul R, et al. Disruption of amyloid precursor protein ubiquitination selectively increases amyloid ? (A?) 40 levels via presenilin 2-mediated cleavage. J Biol Chem. 2017;292:19873-19889 pubmed publisher
Colvin B, Rogers V, Kulas J, Ridgway E, Amtashar F, Combs C, et al. The conformational epitope for a new A?42 protofibril-selective antibody partially overlaps with the peptide N-terminal region. J Neurochem. 2017;143:736-749 pubmed publisher
Mass E, Jacome Galarza C, Blank T, Lazarov T, Durham B, Ozkaya N, et al. A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease. Nature. 2017;549:389-393 pubmed publisher
Branca C, Shaw D, Belfiore R, Gokhale V, Shaw A, Foley C, et al. Dyrk1 inhibition improves Alzheimer's disease-like pathology. Aging Cell. 2017;16:1146-1154 pubmed publisher
Kulas J, Puig K, Combs C. Amyloid precursor protein in pancreatic islets. J Endocrinol. 2017;235:49-67 pubmed publisher
Mast N, Saadane A, Valencia Olvera A, Constans J, Maxfield E, Arakawa H, et al. Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease. Neuropharmacology. 2017;123:465-476 pubmed publisher
Liebsch F, Aurousseau M, Bethge T, McGuire H, Scolari S, Herrmann A, et al. Full-length cellular ?-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization. J Biol Chem. 2017;292:13258-13270 pubmed publisher
Schultz V, van der Meer F, Wrzos C, Scheidt U, Bahn E, Stadelmann C, et al. Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination. Glia. 2017;65:1350-1360 pubmed publisher
Bussiere R, Lacampagne A, Reiken S, Liu X, Scheuerman V, Zalk R, et al. Amyloid ? production is regulated by ?2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor. J Biol Chem. 2017;292:10153-10168 pubmed publisher
Lagumersindez Denis N, Wrzos C, Mack M, Winkler A, van der Meer F, Reinert M, et al. Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis. Acta Neuropathol. 2017;134:15-34 pubmed publisher
Chapuis J, Flaig A, Grenier Boley B, Eysert F, Pottiez V, Deloison G, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathol. 2017;133:955-966 pubmed publisher
Saab A, Tzvetavona I, Trevisiol A, Baltan S, Dibaj P, Kusch K, et al. Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism. Neuron. 2016;91:119-32 pubmed publisher
Chen A, Kim S, Shepardson N, Patel S, Hong S, Selkoe D. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015;211:1157-76 pubmed publisher
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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