| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; loading ...; fig 1a
| Jarosz Griffiths H, Corbett N, Rowland H, Fisher K, Jones A, Baron J, et al. Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers. J Biol Chem. 2019;294:7085-7097 pubmed publisher |
- western blot; mouse; 1:50; loading ...; fig 1b
| Tsatsanis A, Dickens S, Kwok J, Wong B, Duce J. Post Translational Modulation of β-Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis. Neurochem Res. 2019;44:1367-1374 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 3 mg/ml; loading ...; fig 8c
| Jordão M, Sankowski R, Brendecke S, Sagar -, Locatelli G, Tai Y, et al. Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation. Science. 2019;363: pubmed publisher |
- western blot; human; loading ...; fig 2a
| Visconte C, Canino J, Guidetti G, Zarà M, Seppi C, Abubaker A, et al. Amyloid precursor protein is required for in vitro platelet adhesion to amyloid peptides and potentiation of thrombus formation. Cell Signal. 2018;52:95-102 pubmed publisher |
- western blot; human; loading ...; fig 2b
| Xu S, Nigam S, Brodin L. Overexpression of SNX3 Decreases Amyloid-β Peptide Production by Reducing Internalization of Amyloid Precursor Protein. Neurodegener Dis. 2018;18:26-37 pubmed publisher |
- western blot; rat; 1:10,000; loading ...; fig 1b
| Ji C, Steimle B, Bailey D, Kosman D. The Ferroxidase Hephaestin But Not Amyloid Precursor Protein is Required for Ferroportin-Supported Iron Efflux in Primary Hippocampal Neurons. Cell Mol Neurobiol. 2018;38:941-954 pubmed publisher |
- western blot; human; loading ...; fig 4e
| Liebsch F, Aurousseau M, Bethge T, McGuire H, Scolari S, Herrmann A, et al. Full-length cellular ?-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization. J Biol Chem. 2017;292:13258-13270 pubmed publisher |
- western blot; mouse; 1:1000; fig s7e
| Sterky F, Trotter J, Lee S, Recktenwald C, Du X, Zhou B, et al. Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand. Proc Natl Acad Sci U S A. 2017;114:E1253-E1262 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 1m
| Michailidou I, Naessens D, Hametner S, Guldenaar W, Kooi E, Geurts J, et al. Complement C3 on microglial clusters in multiple sclerosis occur in chronic but not acute disease: Implication for disease pathogenesis. Glia. 2017;65:264-277 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:2000; fig 3g
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- western blot; mouse; 1:1000; fig 2a
| Sun M, Asghar S, Zhang H. The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb. Neurobiol Dis. 2016;93:1-11 pubmed publisher |
| Hashimoto Y, Toyama Y, Kusakari S, Nawa M, Matsuoka M. An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid ? Precursor Protein Signaling. J Biol Chem. 2016;291:12282-93 pubmed publisher |
- western blot; human; 1:1000; fig 3
- western blot; mouse; 1:1000; fig 3
| Xu G, Ran Y, Fromholt S, Fu C, Yachnis A, Golde T, et al. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathol Commun. 2015;3:72 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3c
| Bonnemaison M, Bäck N, Duffy M, Ralle M, Mains R, Eipper B. Adaptor Protein-1 Complex Affects the Endocytic Trafficking and Function of Peptidylglycine α-Amidating Monooxygenase, a Luminal Cuproenzyme. J Biol Chem. 2015;290:21264-79 pubmed publisher |
- western blot; mouse; fig 2f
| Liu J, Liu S, Matsumoto Y, Murakami S, Sugakawa Y, Kami A, et al. Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology. Sci Rep. 2015;5:12059 pubmed publisher |
- immunoprecipitation; human; loading ...; fig 1b
| Cuddy L, Seah C, Pasternak S, Rylett R. Differential regulation of the high-affinity choline transporter by wild-type and Swedish mutant amyloid precursor protein. J Neurochem. 2015;134:769-82 pubmed publisher |
- western blot; rat; 1:1000; fig 7
| Jadhav S, Katina S, Kovac A, Kazmerova Z, Novak M, Zilka N. Truncated tau deregulates synaptic markers in rat model for human tauopathy. Front Cell Neurosci. 2015;9:24 pubmed publisher |
- immunoprecipitation; human; fig 1b
- western blot; human; fig 1b
| Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido T, et al. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. EMBO Mol Med. 2015;7:175-89 pubmed publisher |
| Lin T, Shih Y, Chen S, Lien C, Chang C, Huang T, et al. Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer's disease (APP/PS1) transgenic mice. Neurobiol Learn Mem. 2015;118:189-97 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:1000
- western blot; human; 1:1000
| Guo L, Alekseev O, Li Y, Song Y, Dunaief J. Iron increases APP translation and amyloid-beta production in the retina. Exp Eye Res. 2014;129:31-7 pubmed publisher |
- immunocytochemistry; mouse; 1:100
| Joshi G, Gan K, Johnson D, Johnson J. Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy. Neurobiol Aging. 2015;36:664-79 pubmed publisher |
- western blot; mouse; 1:2000
| Sadleir K, Eimer W, Kaufman R, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS ONE. 2014;9:e101643 pubmed publisher |
| Kosicek M, Wunderlich P, Walter J, Hecimovic S. GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells. Biochem Biophys Res Commun. 2014;450:160-5 pubmed publisher |
| Almenar Queralt A, Kim S, Benner C, Herrera C, Kang D, Garcia Bassets I, et al. Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. J Biol Chem. 2013;288:35222-36 pubmed publisher |
- immunocytochemistry; mouse
| Muresan V, Villegas C, Ladescu Muresan Z. Functional interaction between amyloid-? precursor protein and peripherin neurofilaments: a shared pathway leading to Alzheimer's disease and amyotrophic lateral sclerosis?. Neurodegener Dis. 2014;13:122-5 pubmed publisher |
- immunoprecipitation; human
- western blot; human
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| Grant M, Shapiro S, Ashe K, Liu P, Zahs K. A Cautionary Tale: Endogenous Biotinylated Proteins and Exogenously-Introduced Protein A Cause Antibody-Independent Artefacts in Western Blot Studies of Brain-Derived Proteins. Biol Proced Online. 2019;21:6 pubmed publisher |
| Dinamarca M, Raveh A, Schneider A, Fritzius T, Früh S, Rem P, et al. Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing. Nat Commun. 2019;10:1331 pubmed publisher |
| Chen X, Kordich J, Williams E, Levine N, Cole Strauss A, Marshall L, et al. Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration. Proc Natl Acad Sci U S A. 2019;116:5765-5774 pubmed publisher |
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| Sun J, Carlson Stevermer J, Das U, Shen M, Delenclos M, Snead A, et al. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nat Commun. 2019;10:53 pubmed publisher |
| Evans C, Thomas R, Freeman T, Hvoslef Eide M, Good M, Kidd E. Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice. Neurobiol Aging. 2019;75:136-149 pubmed publisher |
| Coronel R, Lachgar M, Bernabeu Zornoza A, Palmer C, Domínguez Alvaro M, Revilla A, et al. Neuronal and Glial Differentiation of Human Neural Stem Cells Is Regulated by Amyloid Precursor Protein (APP) Levels. Mol Neurobiol. 2019;56:1248-1261 pubmed publisher |
| Tsang J, Lee M, Chan T, Li J, Ni Y, Shao Y, et al. Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer. EBioMedicine. 2018;38:89-99 pubmed publisher |
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| Heisler F, Pechmann Y, Wieser I, Altmeppen H, Veenendaal L, Muhia M, et al. Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression. Neuron. 2018;99:1155-1169.e9 pubmed publisher |
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| Voet S, Mc Guire C, Hagemeyer N, Martens A, Schroeder A, Wieghofer P, et al. A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation. Nat Commun. 2018;9:2036 pubmed publisher |
| Nagata K, Takahashi M, Matsuba Y, Okuyama Uchimura F, Sato K, Hashimoto S, et al. Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathology. Nat Commun. 2018;9:1800 pubmed publisher |
| Ruiz Riquelme A, Lau H, Stuart E, Goczi A, Wang Z, Schmitt Ulms G, et al. Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression. Acta Neuropathol Commun. 2018;6:26 pubmed publisher |
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| Lukas D, Yogev N, Kel J, Regen T, Mufazalov I, Tang Y, et al. TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity. Proc Natl Acad Sci U S A. 2017;114:E1480-E1489 pubmed publisher |
| Chapuis J, Flaig A, Grenier Boley B, Eysert F, Pottiez V, Deloison G, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathol. 2017;133:955-966 pubmed publisher |
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| Fernandez M, Klutkowski J, Freret T, Wolfe M. Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ. J Biol Chem. 2014;289:31043-52 pubmed publisher |
| Mosser S, Alattia J, Dimitrov M, Matz A, Pascual J, Schneider B, et al. The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain. Hum Mol Genet. 2015;24:371-82 pubmed publisher |
| Weitz T, Gate D, Rezai Zadeh K, Town T. MyD88 is dispensable for cerebral amyloidosis and neuroinflammation in APP/PS1 transgenic mice. Am J Pathol. 2014;184:2855-61 pubmed publisher |
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| Brunn A, Mihelcic M, Carstov M, Hummel L, Geier F, Schmidt A, et al. IL-10, IL-4, and STAT6 promote an M2 milieu required for termination of P0(106-125)-induced murine experimental autoimmune neuritis. Am J Pathol. 2014;184:2627-40 pubmed publisher |
| Lin Y, Wang J, Wang K, Liao J, Cheng I. Differential regulation of amyloid precursor protein sorting with pathological mutations results in a distinct effect on amyloid-? production. J Neurochem. 2014;131:407-12 pubmed publisher |
| Mc Guire C, Elton L, Wieghofer P, Staal J, Voet S, Demeyer A, et al. Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis. J Neuroinflammation. 2014;11:124 pubmed publisher |
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| Lin L, Yang S, Chu J, Wang L, Ning L, Zhang T, et al. Region-specific expression of tau, amyloid-? protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats. J Alzheimers Dis. 2014;41:1149-63 pubmed publisher |
| Sullivan S, Dillon G, Sullivan J, Ho A. Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid ? generation. J Biol Chem. 2014;289:15374-83 pubmed publisher |
| Trazzi S, Fuchs C, De Franceschi M, Mitrugno V, Bartesaghi R, Ciani E. APP-dependent alteration of GSK3? activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2014;67:24-36 pubmed publisher |
| Rodrigues D, Gutierres J, Pliássova A, Oliveira C, Cunha R, Agostinho P. Synaptic and sub-synaptic localization of amyloid-? protein precursor in the rat hippocampus. J Alzheimers Dis. 2014;40:981-92 pubmed publisher |
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| Notter T, Knuesel I. Reelin immunoreactivity in neuritic varicosities in the human hippocampal formation of non-demented subjects and Alzheimer's disease patients. Acta Neuropathol Commun. 2013;1:27 pubmed publisher |
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| Nelson C, Sheng M. Gpr3 stimulates A? production via interactions with APP and ?-arrestin2. PLoS ONE. 2013;8:e74680 pubmed publisher |
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| Toneff T, Funkelstein L, Mosier C, Abagyan A, Ziegler M, Hook V. Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters. Peptides. 2013;46:126-35 pubmed publisher |
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| Lim Y, Murray L, Lai M, Chen C. NeuroAiD® (MLC601) and amyloid precursor protein processing. Cerebrovasc Dis. 2013;35 Suppl 1:30-7 pubmed publisher |
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| Beckett T, Studzinski C, Keller J, Paul Murphy M, Niedowicz D. A ketogenic diet improves motor performance but does not affect ?-amyloid levels in a mouse model of Alzheimer's disease. Brain Res. 2013;1505:61-7 pubmed publisher |
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