This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Growth Associated Protein 43 Antibody, clone 9-1E12
catalog :
MAB347
quantity :
50 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
9-1E12
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
citations: 69
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 2e
Sun Y, Liu Z, Cao X, Lu Y, Mi Z, He C, et al. Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease. Sci Adv. 2019;5:eaaw3593 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 5a
Poulopoulos A, Murphy A, Ozkan A, Davis P, Hatch J, Kirchner R, et al. Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex. Nature. 2019;565:356-360 pubmed publisher
  • western blot; mouse; 1:400; loading ...; fig 5c
Lim E, Nakanishi S, Hoghooghi V, Eaton S, Palmer A, Frederick A, et al. AlphaB-crystallin regulates remyelination after peripheral nerve injury. Proc Natl Acad Sci U S A. 2017;114:E1707-E1716 pubmed publisher
  • western blot; mouse; fig 1b
Now H, Yoo J. AG490 and PF431396 Sensitive Tyrosine Kinase Control the Population Heterogeneity of Basal STAT1 Activity in Ube1l Deficient Cells. PLoS ONE. 2016;11:e0159453 pubmed publisher
  • western blot; mouse; 1:1000; fig 2
Li H, Ruberu K, Karl T, Garner B. Cerebral Apolipoprotein-D Is Hypoglycosylated Compared to Peripheral Tissues and Is Variably Expressed in Mouse and Human Brain Regions. PLoS ONE. 2016;11:e0148238 pubmed publisher
  • western blot; human; 1:1000; fig 3
Akizu N, Cantagrel V, Zaki M, Al Gazali L, Wang X, Rosti R, et al. Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Nat Genet. 2015;47:528-34 pubmed publisher
  • western blot; mouse; 1:5000
Uys J, McGuier N, Gass J, Griffin W, Ball L, Mulholland P. Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines. Addict Biol. 2016;21:560-74 pubmed publisher
  • immunohistochemistry; mouse; 1:400
de Andrade G, Kunzelman L, Merrill M, Fuerst P. Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina. Mol Vis. 2014;20:1422-33 pubmed
  • western blot; human; fig 5
Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, et al. YAP/TAZ incorporation in the ?-catenin destruction complex orchestrates the Wnt response. Cell. 2014;158:157-70 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:1500
Harris N, Nogueira M, Verley D, Sutton R. Chondroitinase enhances cortical map plasticity and increases functionally active sprouting axons after brain injury. J Neurotrauma. 2013;30:1257-69 pubmed publisher
  • immunohistochemistry; mouse; 1:500
Cygnar K, Collins S, Ferguson C, Bodkin Clarke C, Zhao H. Phosphorylation of adenylyl cyclase III at serine1076 does not attenuate olfactory response in mice. J Neurosci. 2012;32:14557-62 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Moldrich R, Gobius I, Pollak T, Zhang J, Ren T, Brown L, et al. Molecular regulation of the developing commissural plate. J Comp Neurol. 2010;518:3645-61 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:200
Gribaudo S, Bovetti S, Garzotto D, Fasolo A, De Marchis S. Expression and localization of the calmodulin-binding protein neurogranin in the adult mouse olfactory bulb. J Comp Neurol. 2009;517:683-94 pubmed publisher
  • immunohistochemistry; rat; 1:10000
Chao T, Pham K, Steward O, Gupta R. Chronic nerve compression injury induces a phenotypic switch of neurons within the dorsal root ganglia. J Comp Neurol. 2008;506:180-93 pubmed
Heusinger J, Hildebrandt H, Illing R. Sensory deafferentation modulates and redistributes neurocan in the rat auditory brainstem. Brain Behav. 2019;9:e01353 pubmed publisher
Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, et al. The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ. Nature. 2018;563:265-269 pubmed publisher
Zanconato F, Battilana G, Forcato M, Filippi L, Azzolin L, Manfrin A, et al. Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4. Nat Med. 2018;24:1599-1610 pubmed publisher
Pedraza C, Taylor C, Pereira A, Seng M, Tham C, Izrael M, et al. Induction of oligodendrocyte differentiation and in vitro myelination by inhibition of rho-associated kinase. ASN Neuro. 2014;6: pubmed publisher
Ogawa T, Takezawa K, Shimizu S, Shimizu T. Valproic acid promotes neural regeneration of olfactory epithelium in adult mice after methimazole-induced damage. Am J Rhinol Allergy. 2014;28:e95-9 pubmed publisher
Rosskothen Kuhl N, Illing R. Gap43 transcription modulation in the adult brain depends on sensory activity and synaptic cooperation. PLoS ONE. 2014;9:e92624 pubmed publisher
Pantazopoulos H, Boyer Boiteau A, Holbrook E, Jang W, Hahn C, Arnold S, et al. Proteoglycan abnormalities in olfactory epithelium tissue from subjects diagnosed with schizophrenia. Schizophr Res. 2013;150:366-72 pubmed publisher
Amemori T, Romanyuk N, Jendelova P, Herynek V, Turnovcova K, Prochazka P, et al. Human conditionally immortalized neural stem cells improve locomotor function after spinal cord injury in the rat. Stem Cell Res Ther. 2013;4:68 pubmed publisher
Kraus K, Ding D, Jiang H, Kermany M, Mitra S, Salvi R. Up-regulation of GAP-43 in the chinchilla ventral cochlear nucleus after carboplatin-induced hearing loss: correlations with inner hair cell loss and outer hair cell loss. Hear Res. 2013;302:74-82 pubmed publisher
Canterini S, Carletti V, Nusca S, Mangia F, Fiorenza M. Multiple TSC22D4 iso-/phospho-glycoforms display idiosyncratic subcellular localizations and interacting protein partners. FEBS J. 2013;280:1320-9 pubmed publisher
Malavasi E, Ogawa F, Porteous D, Millar J. DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription. Hum Mol Genet. 2012;21:2779-92 pubmed publisher
Yan L, Zhao H, Zhang Y, Shen Y. Differential effects of AdOx on gene expression in P19 embryonal carcinoma cells. BMC Neurosci. 2012;13:6 pubmed publisher
Fredrich M, Illing R. Deafferentation-induced redistribution of MMP-2, but not of MMP-9, depends on the emergence of GAP-43 positive axons in the adult rat cochlear nucleus. Neural Plast. 2011;2011:859359 pubmed publisher
Stephan A, Tobochnik S, Dibattista M, Wall C, Reisert J, Zhao H. The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response. Nat Neurosci. 2011;15:131-7 pubmed publisher
Nguyen B, Li H, Fishbein M, Lin S, Gaudio C, Chen P, et al. Acute myocardial infarction induces bilateral stellate ganglia neural remodeling in rabbits. Cardiovasc Pathol. 2012;21:143-8 pubmed publisher
Buchanan F, Rochette Egly C, Asson Batres M. Detection of variable levels of RAR? and RAR? proteins in pluripotent and differentiating mouse embryonal carcinoma and mouse embryonic stem cells. Cell Tissue Res. 2011;346:43-51 pubmed publisher
Hildebrandt H, Hoffmann N, Illing R. Synaptic reorganization in the adult rat's ventral cochlear nucleus following its total sensory deafferentation. PLoS ONE. 2011;6:e23686 pubmed publisher
Kraus K, Ding D, Jiang H, Lobarinas E, Sun W, Salvi R. Relationship between noise-induced hearing-loss, persistent tinnitus and growth-associated protein-43 expression in the rat cochlear nucleus: does synaptic plasticity in ventral cochlear nucleus suppress tinnitus?. Neuroscience. 2011;194:309-25 pubmed publisher
Hong S, Kihlken J, Choi S, March K, Lim D. Intramyocardial transplantation of human adipose-derived stromal cell and endothelial progenitor cell mixture was not superior to individual cell type transplantation in improving left ventricular function in rats with myocardial infarction. Int J Cardiol. 2013;164:205-11 pubmed publisher
Scotland P, Patil M, Belugin S, Henry M, Goffin V, Hargreaves K, et al. Endogenous prolactin generated during peripheral inflammation contributes to thermal hyperalgesia. Eur J Neurosci. 2011;34:745-54 pubmed publisher
Liu J, Pinnock S, Herbert J. Novel control by the CA3 region of the hippocampus on neurogenesis in the dentate gyrus of the adult rat. PLoS ONE. 2011;6:e17562 pubmed publisher
Hwang C, Huang H, Chen C, Chien C, Hsu Y, Li C, et al. Enhancer of zeste homolog 2 overexpression in nasopharyngeal carcinoma: an independent poor prognosticator that enhances cell growth. Int J Radiat Oncol Biol Phys. 2012;82:597-604 pubmed publisher
Schnichels S, Heiduschka P, Julien S. Different spatial and temporal protein expressions of repulsive guidance molecule a and neogenin in the rat optic nerve after optic nerve crush with and without lens injury. J Neurosci Res. 2011;89:490-505 pubmed publisher
Masanetz S, Lehmann M. HIV-1 Nef increases astrocyte sensitivity towards exogenous hydrogen peroxide. Virol J. 2011;8:35 pubmed publisher
Samkharadze T, Erkan M, Reiser Erkan C, Demir I, Kong B, Ceyhan G, et al. Pigment epithelium-derived factor associates with neuropathy and fibrosis in pancreatic cancer. Am J Gastroenterol. 2011;106:968-80 pubmed publisher
Webster M, Elashoff M, Weickert C. Molecular evidence that cortical synaptic growth predominates during the first decade of life in humans. Int J Dev Neurosci. 2011;29:225-36 pubmed publisher
Ochi N, Doi K, Uranagase M, Nishikawa T, Katsunuma S, Nibu K. Bone marrow stem cell transplantation to olfactory epithelium. Ann Otol Rhinol Laryngol. 2010;119:535-40 pubmed
Harris N, Mironova Y, Hovda D, Sutton R. Chondroitinase ABC enhances pericontusion axonal sprouting but does not confer robust improvements in behavioral recovery. J Neurotrauma. 2010;27:1971-82 pubmed publisher
Lee J, Li C, Fang F, Wang J, Jeng Y, Yu S, et al. Prognostic implication of MET overexpression in myxofibrosarcomas: an integrative array comparative genomic hybridization, real-time quantitative PCR, immunoblotting, and immunohistochemical analysis. Mod Pathol. 2010;23:1379-92 pubmed publisher
Nakayama J, Takao T, Kiuchi H, Yamamoto K, Fukuhara S, Miyagawa Y, et al. Olfactory mucosal transplantation after spinal cord injury improves voiding efficiency by suppressing detrusor-sphincter dyssynergia in rats. J Urol. 2010;184:775-82 pubmed publisher
Fredrich M, Illing R. MMP-2 is involved in synaptic remodeling after cochlear lesion. Neuroreport. 2010;21:324-7 pubmed publisher
Harris N, Mironova Y, Hovda D, Sutton R. Pericontusion axon sprouting is spatially and temporally consistent with a growth-permissive environment after traumatic brain injury. J Neuropathol Exp Neurol. 2010;69:139-54 pubmed publisher
Foscarin S, Gianola S, Carulli D, Fazzari P, Mi S, Tamagnone L, et al. Overexpression of GAP-43 modifies the distribution of the receptors for myelin-associated growth-inhibitory proteins in injured Purkinje axons. Eur J Neurosci. 2009;30:1837-48 pubmed publisher
Wei Y, Li C, Yu S, Chou F, Fang F, Eng H, et al. Ezrin overexpression in gastrointestinal stromal tumors: an independent adverse prognosticator associated with the non-gastric location. Mod Pathol. 2009;22:1351-60 pubmed publisher
Steencken A, Siebert J, Stelzner D. Lack of axonal sprouting of spared propriospinal fibers caudal to spinal contusion injury is attributed to chronic axonopathy. J Neurotrauma. 2009;26:2279-97 pubmed publisher
Sancho R, Law B, Harvey K. Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways. Hum Mol Genet. 2009;18:3955-68 pubmed publisher
Kraus K, Ding D, Zhou Y, Salvi R. Central auditory plasticity after carboplatin-induced unilateral inner ear damage in the chinchilla: up-regulation of GAP-43 in the ventral cochlear nucleus. Hear Res. 2009;255:33-43 pubmed publisher
Nishikawa T, Doi K, Ochi N, Katsunuma S, Nibu K. Effect of intranasal administration of basic fibroblast growth factor on olfactory epithelium. Neuroreport. 2009;20:764-9 pubmed publisher
Thirumangalathu S, HARLOW D, Driskell A, Krimm R, Barlow L. Fate mapping of mammalian embryonic taste bud progenitors. Development. 2009;136:1519-28 pubmed publisher
Cygnar K, Zhao H. Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons. Nat Neurosci. 2009;12:454-62 pubmed publisher
Li C, Huang W, Wu J, Yu S, Hu T, Uen Y, et al. Heat shock protein 90 overexpression independently predicts inferior disease-free survival with differential expression of the alpha and beta isoforms in gastrointestinal stromal tumors. Clin Cancer Res. 2008;14:7822-31 pubmed publisher
Cai L, Johnstone B, Cook T, Tan J, Fishbein M, Chen P, et al. IFATS collection: Human adipose tissue-derived stem cells induce angiogenesis and nerve sprouting following myocardial infarction, in conjunction with potent preservation of cardiac function. Stem Cells. 2009;27:230-7 pubmed publisher
Xu Q, Midha R, Martinez J, Guo G, Zochodne D. Facilitated sprouting in a peripheral nerve injury. Neuroscience. 2008;152:877-87 pubmed publisher
Andrews M, Stelzner D. Evaluation of olfactory ensheathing and schwann cells after implantation into a dorsal injury of adult rat spinal cord. J Neurotrauma. 2007;24:1773-92 pubmed
Meikle L, Talos D, Onda H, Pollizzi K, Rotenberg A, Sahin M, et al. A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival. J Neurosci. 2007;27:5546-58 pubmed
Kimura K, Ieda M, Kanazawa H, Yagi T, Tsunoda M, Ninomiya S, et al. Cardiac sympathetic rejuvenation: a link between nerve function and cardiac hypertrophy. Circ Res. 2007;100:1755-64 pubmed
Watanabe K, Kondo K, Takeuchi N, Okano H, Yamasoba T. Musashi-1 expression in postnatal mouse olfactory epithelium. Neuroreport. 2007;18:641-4 pubmed
Lippert Gruener M, Maegele M, Garbe J, Angelov D. Late effects of enriched environment (EE) plus multimodal early onset stimulation (MEOS) after traumatic brain injury in rats: Ongoing improvement of neuromotor function despite sustained volume of the CNS lesion. Exp Neurol. 2007;203:82-94 pubmed
Li S, Carmichael S. Growth-associated gene and protein expression in the region of axonal sprouting in the aged brain after stroke. Neurobiol Dis. 2006;23:362-73 pubmed
Liu X, Hawkes E, Ishimaru T, Tran T, Sretavan D. EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury. J Neurosci. 2006;26:3087-101 pubmed
Asson Batres M, Smith W. Localization of retinaldehyde dehydrogenases and retinoid binding proteins to sustentacular cells, glia, Bowman's gland cells, and stroma: potential sites of retinoic acid synthesis in the postnatal rat olfactory organ. J Comp Neurol. 2006;496:149-71 pubmed
Huang H, Kang H, Li C, Eng H, Chou S, Lin C, et al. Skp2 overexpression is highly representative of intrinsic biological aggressiveness and independently associated with poor prognosis in primary localized myxofibrosarcomas. Clin Cancer Res. 2006;12:487-98 pubmed
Hsu J, Xu X. Early profiles of axonal growth and astroglial response after spinal cord hemisection and implantation of Schwann cell-seeded guidance channels in adult rats. J Neurosci Res. 2005;82:472-83 pubmed
Hsu J, Stein S, Xu X. Temporal and spatial distribution of growth-associated molecules and astroglial cells in the rat corticospinal tract during development. J Neurosci Res. 2005;80:330-40 pubmed
Kerschensteiner M, Bareyre F, Buddeberg B, Merkler D, Stadelmann C, Bruck W, et al. Remodeling of axonal connections contributes to recovery in an animal model of multiple sclerosis. J Exp Med. 2004;200:1027-38 pubmed
product information
Catalog Number :
MAB347
Subcategory :
Neuroscience
Product Name :
Anti-Growth Associated Protein 43 Antibody, clone 9-1E12
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P17677
Host Name :
Mouse
Antigen :
Growth Associated Protein 43
Clone :
9-1E12
Conjugate :
Purified
Isotype :
IgG1
Product Description :
Anti-Growth Associated Protein 43 Antibody, clone 9-1E12
Cross Reactivity :
Human;Rat;Feline;Hamster
Background :
GAP-43, a common marker of differentiating neurons, is expressed at elevated levels by developing or regenerating neurons during axon growth. While GAP-43 is an integral membrane protein associated with the cytoplasmic surface of axonal growth cones (and synapses), it is absent from dendritic growth cones. In adult brain, GAP-43 is found in high concentration in presynaptic areas where memory formation is thought to occur, such as frontal cortex, limbic system and hippocampus. Phosphorylation of GAP-43 by PKC (at Ser41 on human, mouse, rat, and bovine GAP-43 or Ser42 on chicken and Xenopus GAP-43) is specifically correlated with certain forms of synaptic plasticity.
ALT Names :
Neuromodulin;B-50 Protein;Growth Associated Protein 43;neuromodulin
Immunogen :
GAP-43 purified from rat brain
Specificity :
GAP-43 (also known as growth associated protein-43, B-50, F1 and pp46), regardless of the protein’s phosphorylation state.
Package Size :
50 µg
Uses :
Immunohistochemistry;Immunoprecipitation;Western Blotting
Storage :
Maintain at 2-8°C in undiluted for up to 6 months after date of receipt.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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