Cyclooxygenase-2 Antibody, clone AS66 | EMD Millipore MAB3462 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Cyclooxygenase-2 Antibody, clone AS66

catalog :

MAB3462

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AS66

The same clone is also sold as:

Abnova: MAB1847

reactivity :

human, rat

application :

western blot, ELISA, flow cytometry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:1000	Wang Y, Li Q, Wei X, Xu J, Chen Q, Song S, et al. Targeted knockout of TNF-? by injection of lentivirus-mediated siRNA into the subacromial bursa for the treatment of subacromial bursitis in rats. Mol Med Rep. 2015;12:4389-4395 pubmed publisher

product information

Catalog Number :

MAB3462

Subcategory :

Neuroscience

Product Name :

Anti-Cyclooxygenase-2 Antibody, clone AS66

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P35354

Host Name :

Mouse

Antigen :

Cyclooxygenase-2

Clone :

AS66

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Cyclooxygenase-2 Antibody, clone AS66

Cross Reactivity :

Human

Background :

Cyclooxygenase (COX), also known as Prostaglandin H2 synthase and Prostaglandin endoperoxide synthase, is a key enzyme in the conversion of arachidonic acid to Prostaglandin H2. Prostaglandin H2 is converted by other enzymes into inflammatory mediators prostaglandin (PG), D2, PGE2, PGF2a, PG12 and Thromboxane A2. Thus, COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activties. There are two enzymes of COX, COX 1 and COX 2. COX-1 is constitutively produced in many (most) cell types. It is important in the gut for the production of prostaglandins, which inhibit gastric secretion. It can be induced in monocytes, macrophages and other cells. It is induced as part of the inflammatory response by IL-1 beta and other cytokines. It is induced by growth factors such as EGF and PDGF. Expression is inhibited by glucocorticosteroids such as cortisol and dexamethasone. Lipopolysaccharide in bacterial infections induces COX-2. COX-2 is also found in elevated levels in synoviocytes from rheumatoid arthritis patients. The discomforts of inflammation such as pain and swelling are largely due to action of prostaglandins produced by COX-2.

ALT Names :

COX II

Immunogen :

Full length recombinant human Cox-2.

Specificity :

Human Cyclooxygenase 2 (COX-2).

Package Size :

100 µg

Uses :

ELISA;Flow Cytometry;Western Blotting

Storage :

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.