This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
O4 Antibody, clone 81
catalog :
MAB345
quantity :
50 μg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
81
reactivity :
guinea pig, human, mouse, rat, domestic sheep
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments
citations: 121
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; rat; 1:1000; loading ...; fig 5d
Mecha M, Yanguas Casás N, Feliú A, Mestre L, Carrillo Salinas F, Riecken K, et al. Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis. J Neuroinflammation. 2020;17:88 pubmed publisher
  • immunohistochemistry; rat; 1:1000; loading ...; fig 5h
Rahman A, Weber J, Labin E, Lai C, Prieto A. Developmental expression of Neuregulin-3 in the rat central nervous system. J Comp Neurol. 2019;527:797-817 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s7a
Zhao C, Dong C, Frah M, Deng Y, Marie C, Zhang F, et al. Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Dev Cell. 2018;45:753-768.e8 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250; loading ...; fig s7c
Kuroda M, Muramatsu R, Maedera N, Koyama Y, Hamaguchi M, Fujimura H, et al. Peripherally derived FGF21 promotes remyelination in the central nervous system. J Clin Invest. 2017;127:3496-3509 pubmed publisher
  • immunohistochemistry; guinea pig; 1:100; loading ...; fig 2c
Hatakeyama J, Sato H, Shimamura K. Developing guinea pig brain as a model for cortical folding. Dev Growth Differ. 2017;59:286-301 pubmed publisher
  • immunocytochemistry; mouse; 1:150; loading ...; fig 2b
Mendivil Perez M, Soto Mercado V, Guerra Librero A, Fernandez Gil B, Florido J, Shen Y, et al. Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function. J Pineal Res. 2017;63: pubmed publisher
  • immunocytochemistry; human; 1:200; fig s4a
Lee I, Koo K, Jung K, Kim M, Kim I, Hwang K, et al. Neurogenin-2-transduced human neural progenitor cells attenuate neonatal hypoxic-ischemic brain injury. Transl Res. 2017;183:121-136.e9 pubmed publisher
  • immunocytochemistry; mouse; 1:500; loading ...; fig 3
Kim J, Lee J, Sun W. Isolation and Culture of Adult Neural Stem Cells from the Mouse Subcallosal Zone. J Vis Exp. 2016;: pubmed publisher
  • blocking or activating experiments; rat; loading ...
Wolfes A, Ahmed S, Awasthi A, Stahlberg M, Rajput A, Magruder D, et al. A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes. J Gen Physiol. 2017;149:149-170 pubmed publisher
  • immunohistochemistry - frozen section; mouse
Fogarty L, Song B, Suppiah Y, Hasan S, Martin H, Hogan S, et al. Bcl-xL dependency coincides with the onset of neurogenesis in the developing mammalian spinal cord. Mol Cell Neurosci. 2016;77:34-46 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 1k
Li H, Li H, Hao Y, Jiao Y, Li Z, Yue H, et al. Differential long non?coding RNA and mRNA expression in differentiated human glioblastoma stem cells. Mol Med Rep. 2016;14:2067-76 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; fig s4a
Nagao M, Ogata T, Sawada Y, Gotoh Y. Zbtb20 promotes astrocytogenesis during neocortical development. Nat Commun. 2016;7:11102 pubmed publisher
  • immunocytochemistry; human; 1:200
Sancho Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, et al. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016;7:10743 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; fig 3
Beaudet M, Yang Q, Cadau S, Blais M, Bellenfant S, Gros Louis F, et al. High yield extraction of pure spinal motor neurons, astrocytes and microglia from single embryo and adult mouse spinal cord. Sci Rep. 2015;5:16763 pubmed publisher
  • blocking or activating experiments; rat
Peckham H, Giuffrida L, Wood R, Gonsalvez D, Ferner A, Kilpatrick T, et al. Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination. Glia. 2016;64:255-69 pubmed publisher
  • immunocytochemistry; mouse; 1:500
Liu Y, Miao Q, Yuan J, Han S, Zhang P, Li S, et al. Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo. J Neurosci. 2015;35:9336-55 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200
  • immunocytochemistry; mouse; 1:200
Kapuralin K, Ćurlin M, Mitrečić D, Kosi N, Schwarzer C, Glavan G, et al. STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons. Mol Cell Neurosci. 2015;67:104-15 pubmed publisher
  • immunocytochemistry; rat; 1:150; loading ...; fig s3b
Jimenez Blasco D, Santofimia Castaño P, Gonzalez A, Almeida A, Bolaños J. Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway. Cell Death Differ. 2015;22:1877-89 pubmed publisher
  • immunohistochemistry; mouse; 1:25
Miller N, Feng Z, Edens B, Yang B, Shi H, Sze C, et al. Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy. J Neurosci. 2015;35:6038-50 pubmed publisher
  • immunocytochemistry; human; 1:1000
Crouch E, Liu C, Silva Vargas V, Doetsch F. Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J Neurosci. 2015;35:4528-39 pubmed publisher
  • immunocytochemistry; mouse; 1:200; loading ...; fig 6c
Serrano Pérez M, Fernández M, Neria F, Berjón Otero M, Doncel Pérez E, Cano E, et al. NFAT transcription factors regulate survival, proliferation, migration, and differentiation of neural precursor cells. Glia. 2015;63:987-1004 pubmed publisher
  • immunohistochemistry; mouse; 1:400; fig 3
Giera S, Deng Y, Luo R, Ackerman S, Mogha A, Monk K, et al. The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun. 2015;6:6121 pubmed publisher
  • immunohistochemistry - paraffin section; domestic sheep; 1:100
Kitanishi R, Matsuda T, Watanabe S, Saito M, Hanita T, Watanabe T, et al. Cerebral ischemia or intrauterine inflammation promotes differentiation of oligodendroglial precursors in preterm ovine fetuses: possible cellular basis for white matter injury. Tohoku J Exp Med. 2014;234:299-307 pubmed
  • immunocytochemistry; mouse; fig s6
Pooya S, Liu X, Kumar V, Anderson J, Imai F, Zhang W, et al. The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism. Nat Commun. 2014;5:4993 pubmed publisher
  • immunohistochemistry; rat; 1:100
Davis H, Gonzalez M, Stancescu M, Love R, Hickman J, Lambert S. A phenotypic culture system for the molecular analysis of CNS myelination in the spinal cord. Biomaterials. 2014;35:8840-8845 pubmed publisher
  • flow cytometry; mouse; 1:400
Orre M, Kamphuis W, Osborn L, Jansen A, Kooijman L, Bossers K, et al. Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction. Neurobiol Aging. 2014;35:2746-2760 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:200
König N, Trolle C, Kapuralin K, Adameyko I, Mitrecic D, Aldskogius H, et al. Murine neural crest stem cells and embryonic stem cell-derived neuron precursors survive and differentiate after transplantation in a model of dorsal root avulsion. J Tissue Eng Regen Med. 2017;11:129-137 pubmed publisher
  • immunocytochemistry; human
Nguyen H, Nekanti U, Haus D, Funes G, Moreno D, Kamei N, et al. Induction of early neural precursors and derivation of tripotent neural stem cells from human pluripotent stem cells under xeno-free conditions. J Comp Neurol. 2014;522:2767-83 pubmed publisher
  • immunohistochemistry; mouse
Shimizu S, Koyama Y, Hattori T, Tachibana T, Yoshimi T, Emoto H, et al. DBZ, a CNS-specific DISC1 binding protein, positively regulates oligodendrocyte differentiation. Glia. 2014;62:709-24 pubmed publisher
  • flow cytometry; human
  • immunocytochemistry; human; 1:200
Havrda M, Paolella B, Ran C, Jering K, Wray C, Sullivan J, et al. Id2 mediates oligodendrocyte precursor cell maturation arrest and is tumorigenic in a PDGF-rich microenvironment. Cancer Res. 2014;74:1822-32 pubmed publisher
  • immunohistochemistry; mouse; 1:50
Maire C, Ramkissoon S, Hayashi M, Haidar S, Ramkissoon L, diTomaso E, et al. Pten loss in Olig2 expressing neural progenitor cells and oligodendrocytes leads to interneuron dysplasia and leukodystrophy. Stem Cells. 2014;32:313-26 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:100
Feng N, Han Q, Li J, Wang S, Li H, Yao X, et al. Generation of highly purified neural stem cells from human adipose-derived mesenchymal stem cells by Sox1 activation. Stem Cells Dev. 2014;23:515-29 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Bellesi M, Pfister Genskow M, Maret S, Keles S, Tononi G, Cirelli C. Effects of sleep and wake on oligodendrocytes and their precursors. J Neurosci. 2013;33:14288-300 pubmed publisher
  • immunocytochemistry; mouse; 1:300
Azari H. Isolation and enrichment of defined neural cell populations from heterogeneous neural stem cell progeny. Methods Mol Biol. 2013;1059:95-106 pubmed publisher
  • immunocytochemistry; mouse; 1:100
Baptista S, Bento A, Gonçalves J, Bernardino L, Summavielle T, Lobo A, et al. Neuropeptide Y promotes neurogenesis and protection against methamphetamine-induced toxicity in mouse dentate gyrus-derived neurosphere cultures. Neuropharmacology. 2012;62:2413-23 pubmed publisher
  • immunocytochemistry; mouse; 1:100
Gritti A, Dal Molin M, Foroni C, Bonfanti L. Effects of developmental age, brain region, and time in culture on long-term proliferation and multipotency of neural stem cell populations. J Comp Neurol. 2009;517:333-49 pubmed publisher
  • immunohistochemistry; human
Ponti G, Peretto P, Bonfanti L. Genesis of neuronal and glial progenitors in the cerebellar cortex of peripuberal and adult rabbits. PLoS ONE. 2008;3:e2366 pubmed publisher
Er E, Valiente M, Ganesh K, Zou Y, Agrawal S, Hu J, et al. Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nat Cell Biol. 2018;20:966-978 pubmed publisher
Giacci M, Bartlett C, Smith N, Iyer K, Toomey L, Jiang H, et al. Oligodendroglia Are Particularly Vulnerable to Oxidative Damage after Neurotrauma In Vivo. J Neurosci. 2018;38:6491-6504 pubmed publisher
Bai M, Vozdek R, Hnizda A, Jiang C, Wang B, Kuchar L, et al. Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection. Nat Commun. 2018;9:897 pubmed publisher
Zhang M, Jiang M, Kim D, Ahn W, Chung E, Son Y, et al. Comparative Analysis of the Cell Fates of Induced Schwann Cells from Subcutaneous Fat Tissue and Naïve Schwann Cells in the Sciatic Nerve Injury Model. Biomed Res Int. 2017;2017:1252851 pubmed publisher
Ackerman S, Garcia C, Piao X, Gutmann D, Monk K. The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA. Nat Commun. 2015;6:6122 pubmed publisher
Han D, Choi M, Jung K, Kim N, Kim S, Chai J, et al. Global transcriptome profiling of genes that are differentially regulated during differentiation of mouse embryonic neural stem cells into astrocytes. J Mol Neurosci. 2015;55:109-125 pubmed publisher
Thomas A, Seidlits S, Goodman A, Kukushliev T, Hassani D, Cummings B, et al. Sonic hedgehog and neurotrophin-3 increase oligodendrocyte numbers and myelination after spinal cord injury. Integr Biol (Camb). 2014;6:694-705 pubmed publisher
Li Q, Wang H, Zhou G, Jinfei M, Yan L, Zhaihu Z, et al. Production of healthy cloned pigs with neural stem cells as nuclear donors. Anim Biotechnol. 2014;25:294-305 pubmed publisher
Bergsland M, Covacu R, Pérez Estrada C, Svensson M, Brundin L. Nitric oxide-induced neuronal to glial lineage fate-change depends on NRSF/REST function in neural progenitor cells. Stem Cells. 2014;32:2539-49 pubmed publisher
Addington C, Pauken C, Caplan M, STABENFELDT S. The role of SDF-1?-ECM crosstalk in determining neural stem cell fate. Biomaterials. 2014;35:3263-72 pubmed publisher
Fusar Poli E, Zalfa C, D Avanzo F, Tomanin R, Carlessi L, Bossi M, et al. Murine neural stem cells model Hunter disease in vitro: glial cell-mediated neurodegeneration as a possible mechanism involved. Cell Death Dis. 2013;4:e906 pubmed publisher
Aldaz B, Sagardoy A, Nogueira L, Guruceaga E, Grande L, Huse J, et al. Involvement of miRNAs in the differentiation of human glioblastoma multiforme stem-like cells. PLoS ONE. 2013;8:e77098 pubmed publisher
Mikaeili Agah E, Parivar K, Nabiuni M, Hashemi M, Soleimani M. Induction of human umbilical Wharton's jelly-derived stem cells toward oligodendrocyte phenotype. J Mol Neurosci. 2013;51:328-36 pubmed publisher
Orre M, Kamphuis W, Osborn L, Melief J, Kooijman L, Huitinga I, et al. Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice. Neurobiol Aging. 2014;35:1-14 pubmed publisher
Holowacz T, Alexson T, Coles B, Doble B, Kelly K, Woodgett J, et al. The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin. Biol Open. 2013;2:812-21 pubmed publisher
Dugas J, Emery B. Purification of oligodendrocyte precursor cells from rat cortices by immunopanning. Cold Spring Harb Protoc. 2013;2013:745-58 pubmed publisher
Stegeman S, Jolly L, Premarathne S, Gecz J, Richards L, Mackay Sim A, et al. Loss of Usp9x disrupts cortical architecture, hippocampal development and TGF?-mediated axonogenesis. PLoS ONE. 2013;8:e68287 pubmed publisher
Kim J, Kim Y, Chang Y. Administration of dexamethasone to neonatal rats induces hypomyelination and changes in the morphology of oligodendrocyte precursors. Comp Med. 2013;63:48-54 pubmed
Pathipati P, Müller S, Jiang X, Ferriero D. Phenotype and secretory responses to oxidative stress in microglia. Dev Neurosci. 2013;35:241-54 pubmed publisher
Moon Y, Kim J, Choi S, Cho H, Kim H, Sun W. Expression of ezrin in subventricular zone neural stem cells and their progeny in adult and developing mice. Histochem Cell Biol. 2013;139:403-13 pubmed publisher
Liu H, Jia D, Li A, Chau J, He D, Ruan X, et al. p53 regulates neural stem cell proliferation and differentiation via BMP-Smad1 signaling and Id1. Stem Cells Dev. 2013;22:913-27 pubmed publisher
Li J, Tang Y, Cai D. IKK?/NF-?B disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nat Cell Biol. 2012;14:999-1012 pubmed publisher
Coombs I, Soto D, Zonouzi M, Renzi M, Shelley C, Farrant M, et al. Cornichons modify channel properties of recombinant and glial AMPA receptors. J Neurosci. 2012;32:9796-804 pubmed publisher
Rutten M, Janes M, Chang I, Gregory C, Gregory K. Development of a functional schwann cell phenotype from autologous porcine bone marrow mononuclear cells for nerve repair. Stem Cells Int. 2012;2012:738484 pubmed publisher
Ng F, Toh T, Ting E, Koh G, Sandanaraj E, Phong M, et al. Progenitor-like traits contribute to patient survival and prognosis in oligodendroglial tumors. Clin Cancer Res. 2012;18:4122-35 pubmed
Brito C, Simão D, Costa I, Malpique R, Pereira C, Fernandes P, et al. 3D cultures of human neural progenitor cells: dopaminergic differentiation and genetic modification. [corrected]. Methods. 2012;56:452-60 pubmed publisher
Zonouzi M, Renzi M, Farrant M, Cull Candy S. Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells. Nat Neurosci. 2011;14:1430-8 pubmed publisher
Beck S, Jin X, Yin J, Kim S, Lee N, Oh S, et al. Identification of a peptide that interacts with Nestin protein expressed in brain cancer stem cells. Biomaterials. 2011;32:8518-28 pubmed publisher
Ma Z, Wang J, Song F, Loeb J. Critical period of axoglial signaling between neuregulin-1 and brain-derived neurotrophic factor required for early Schwann cell survival and differentiation. J Neurosci. 2011;31:9630-40 pubmed publisher
Girolamo F, Ferrara G, Strippoli M, Rizzi M, Errede M, Trojano M, et al. Cerebral cortex demyelination and oligodendrocyte precursor response to experimental autoimmune encephalomyelitis. Neurobiol Dis. 2011;43:678-89 pubmed publisher
Siebzehnrubl F, Vedam Mai V, Azari H, Reynolds B, Deleyrolle L. Isolation and characterization of adult neural stem cells. Methods Mol Biol. 2011;750:61-77 pubmed publisher
Li Y, Lein P, Liu C, Bruun D, Tewolde T, Ford G, et al. Spatiotemporal pattern of neuronal injury induced by DFP in rats: a model for delayed neuronal cell death following acute OP intoxication. Toxicol Appl Pharmacol. 2011;253:261-9 pubmed publisher
Wang Z, Sugano E, Isago H, Hiroi T, Tamai M, Tomita H. Differentiation of neuronal cells from NIH/3T3 fibroblasts under defined conditions. Dev Growth Differ. 2011;53:357-65 pubmed publisher
Piccin D, Morshead C. Wnt signaling regulates symmetry of division of neural stem cells in the adult brain and in response to injury. Stem Cells. 2011;29:528-38 pubmed publisher
Nogueira L, Ruiz Ontañon P, Vázquez Barquero A, Lafarga M, Berciano M, Aldaz B, et al. Blockade of the NF?B pathway drives differentiating glioblastoma-initiating cells into senescence both in vitro and in vivo. Oncogene. 2011;30:3537-48 pubmed publisher
Holowacz T, Huelsken J, Dufort D, van der Kooy D. Neural stem cells are increased after loss of ?-catenin, but neural progenitors undergo cell death. Eur J Neurosci. 2011;33:1366-75 pubmed publisher
Francis K, Wei L. Human embryonic stem cell neural differentiation and enhanced cell survival promoted by hypoxic preconditioning. Cell Death Dis. 2010;1:e22 pubmed publisher
Shao Z, Luo Q, Liu D, Mi Y, Zhang P, Ju G. Induced differentiation of neural stem cells of astrocytic origin to motor neurons in the rat. Stem Cells Dev. 2011;20:1163-70 pubmed publisher
Yu J, Bunnell B, Kang S. Neural differentiation of human adipose tissue-derived stem cells. Methods Mol Biol. 2011;702:219-31 pubmed publisher
Aizawa T, Hasegawa K, Ohkumo T, Haga S, Ikeda K, Yoshikawa K. Neural stem cell-like gene expression in a mouse ependymoma cell line transformed by human BK polyomavirus. Cancer Sci. 2011;102:122-9 pubmed publisher
Tsuang Y, Liao L, Chao Y, Sun J, Cheng C, Chen M, et al. Effects of low intensity pulsed ultrasound on rat Schwann cells metabolism. Artif Organs. 2011;35:373-83 pubmed publisher
Obokata H, Kojima K, Westerman K, Yamato M, Okano T, Tsuneda S, et al. The potential of stem cells in adult tissues representative of the three germ layers. Tissue Eng Part A. 2011;17:607-15 pubmed publisher
Ichi S, Costa F, Bischof J, Nakazaki H, Shen Y, Boshnjaku V, et al. Folic acid remodels chromatin on Hes1 and Neurog2 promoters during caudal neural tube development. J Biol Chem. 2010;285:36922-32 pubmed publisher
Solbrig M, Fan Y, Hermanowicz N, Morgese M, Giuffrida A. A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats. Exp Neurol. 2010;226:231-41 pubmed publisher
Lee J, Jin Y, Jin J, Kang B, Nam D, Joo K, et al. Functional neural stem cell isolation from brains of adult mutant SOD1 (SOD1(G93A)) transgenic amyotrophic lateral sclerosis (ALS) mice. Neurol Res. 2011;33:33-7 pubmed publisher
Yao S, Ljunggren Rose A, Chandramohan N, Whetsell W, Sriram S. In vitro and in vivo induction and activation of nNOS by LPS in oligodendrocytes. J Neuroimmunol. 2010;229:146-56 pubmed publisher
Abaskharoun M, Bellemare M, Lau E, Margolis R. Glypican-1, phosphacan/receptor protein-tyrosine phosphatase-?/? and its ligand, tenascin-C, are expressed by neural stem cells and neural cells derived from embryonic stem cells. ASN Neuro. 2010;2:e00039 pubmed publisher
Götte M, Hofmann G, Michou Gallani A, Glickman J, Wishart W, Gabriel D. An imaging assay to analyze primary neurons for cellular neurotoxicity. J Neurosci Methods. 2010;192:7-16 pubmed publisher
Wolańczyk M, Hułas Bigoszewska K, Witusik Perkowska M, Papierz W, Jaskolski D, Liberski P, et al. Imperfect oligodendrocytic and neuronal differentiation of glioblastoma cells. Folia Neuropathol. 2010;48:27-34 pubmed
Mitrecic D, Nicaise C, Gajovic S, Pochet R. Distribution, differentiation, and survival of intravenously administered neural stem cells in a rat model of amyotrophic lateral sclerosis. Cell Transplant. 2010;19:537-48 pubmed publisher
Abaskharoun M, Bellemare M, Lau E, Margolis R. Expression of hyaluronan and the hyaluronan-binding proteoglycans neurocan, aggrecan, and versican by neural stem cells and neural cells derived from embryonic stem cells. Brain Res. 2010;1327:6-15 pubmed publisher
Chi G, Kim M, Kim D, Jiang M, Son Y. Schwann cells differentiated from spheroid-forming cells of rat subcutaneous fat tissue myelinate axons in the spinal cord injury. Exp Neurol. 2010;222:304-17 pubmed publisher
Liu K, Li Y, Wang H, Jiang X, Zhao Y, Sun D, et al. The immunohistochemical characterization of human fetal olfactory bulb and olfactory ensheathing cells in culture as a source for clinical CNS restoration. Anat Rec (Hoboken). 2010;293:359-69 pubmed publisher
Markakis E, Sasaki M, Lankford K, Kocsis J. Convergence of cells from the progenitor fraction of adult olfactory bulb tissue to remyelinating glia in demyelinating spinal cord lesions. PLoS ONE. 2009;4:e7260 pubmed publisher
Huang Z, Liu J, Cheung P, Chen C. Long-term cognitive impairment and myelination deficiency in a rat model of perinatal hypoxic-ischemic brain injury. Brain Res. 2009;1301:100-9 pubmed publisher
Liard O, Segura S, Pascual A, Gaudreau P, Fusai T, Moyse E. In vitro isolation of neural precursor cells from the adult pig subventricular zone. J Neurosci Methods. 2009;182:172-9 pubmed publisher
Gordon D, Scolding N. Human mesenchymal stem cell culture for neural transplantation. Methods Mol Biol. 2009;549:103-18 pubmed publisher
Deleyrolle L, Reynolds B. Isolation, expansion, and differentiation of adult Mammalian neural stem and progenitor cells using the neurosphere assay. Methods Mol Biol. 2009;549:91-101 pubmed publisher
Tropepe V, Alton K, Sachewsky N, Cheng V, Kuo C, Morshead C. Neurogenic potential of isolated precursor cells from early post-gastrula somitic tissue. Stem Cells Dev. 2009;18:1533-42 pubmed publisher
Huang Y, Chin C, Ho H, Chou C, Shen C, Kuo H, et al. Pluripotency of mouse spermatogonial stem cells maintained by IGF-1- dependent pathway. FASEB J. 2009;23:2076-87 pubmed publisher
Carlessi L, De Filippis L, Lecis D, Vescovi A, Delia D. DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression. Cell Death Differ. 2009;16:795-806 pubmed publisher
Kowalczyk T, Pontious A, Englund C, Daza R, Bedogni F, Hodge R, et al. Intermediate neuronal progenitors (basal progenitors) produce pyramidal-projection neurons for all layers of cerebral cortex. Cereb Cortex. 2009;19:2439-50 pubmed publisher
Ahn S, Byun K, Kim D, Lee K, Yoo J, Kim S, et al. Olig2-induced neural stem cell differentiation involves downregulation of Wnt signaling and induction of Dickkopf-1 expression. PLoS ONE. 2008;3:e3917 pubmed publisher
De Filippis L, Ferrari D, Rota Nodari L, Amati B, Snyder E, Vescovi A. Immortalization of human neural stem cells with the c-myc mutant T58A. PLoS ONE. 2008;3:e3310 pubmed publisher
Wang Y, Molotkov A, Song L, Li Y, Pleasure D, Zhou C. Activation of the Wnt/beta-catenin signaling reporter in developing mouse olfactory nerve layer marks a specialized subgroup of olfactory ensheathing cells. Dev Dyn. 2008;237:3157-68 pubmed publisher
Yao H, Xie X, Li Y, Wang D, Han S, Shi S, et al. Legume lectin FRIL preserves neural progenitor cells in suspension culture in vitro. Clin Dev Immunol. 2008;2008:531317 pubmed publisher
Martínez Ramos C, Lainez S, Sancho F, García Esparza M, Planells Cases R, Garcia Verdugo J, et al. Differentiation of postnatal neural stem cells into glia and functional neurons on laminin-coated polymeric substrates. Tissue Eng Part A. 2008;14:1365-75 pubmed publisher
Rebetz J, Tian D, Persson A, Widegren B, Salford L, Englund E, et al. Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma. PLoS ONE. 2008;3:e1936 pubmed publisher
Imura T, Tane K, Toyoda N, Fushiki S. Endothelial cell-derived bone morphogenetic proteins regulate glial differentiation of cortical progenitors. Eur J Neurosci. 2008;27:1596-606 pubmed publisher
Cheng S, Carr C. Functional delay of myelination of auditory delay lines in the nucleus laminaris of the barn owl. Dev Neurobiol. 2007;67:1957-74 pubmed
Chen S, Choo A, Nai Dy W, Heng Phon T, Oh S. Knockdown of Oct-4 or Sox-2 attenuates neurogenesis of mouse embryonic stem cells. Stem Cells Dev. 2007;16:413-20 pubmed
Lee S, Choi M, Lee E, Gong S, Jang M, Park S, et al. Establishment of autologous embryonic stem cells derived from preantral follicle culture and oocyte parthenogenesis. Fertil Steril. 2008;90:1910-20 pubmed
Pakkasjärvi N, Kerosuo L, Nousiainen H, Gentile M, Saharinen J, Suhonen S, et al. Neural precursor cells from a fatal human motoneuron disease differentiate despite aberrant gene expression. Dev Neurobiol. 2007;67:270-84 pubmed
Juan L, Dawei Z, Julie A. Increased number and differentiation of neural precursor cells in the brainstem of superoxide dismutase 1(G93A) (G1H) transgenic mouse model of amyotrophic lateral sclerosis. Neurol Res. 2007;29:204-9 pubmed
Francis J, Olariu A, Kobayashi E, Leone P. GFP-transgenic Lewis rats as a cell source for oligodendrocyte replacement. Exp Neurol. 2007;205:177-89 pubmed
De Filippis L, Foglieni C, Silva S, Vescovi A, Lusso P, Malnati M. Differentiated human neural stem cells: a new ex vivo model to study HHV-6 infection of the central nervous system. J Clin Virol. 2006;37 Suppl 1:S27-32 pubmed
Luyt K, Slade T, Dorward J, Durant C, Wu Y, Shigemoto R, et al. Developing oligodendrocytes express functional GABA(B) receptors that stimulate cell proliferation and migration. J Neurochem. 2007;100:822-40 pubmed
Gilbertson J, Sen A, Behie L, Kallos M. Scaled-up production of mammalian neural precursor cell aggregates in computer-controlled suspension bioreactors. Biotechnol Bioeng. 2006;94:783-92 pubmed
Svedin P, Kjellmer I, Welin A, Blad S, Mallard C. Maturational effects of lipopolysaccharide on white-matter injury in fetal sheep. J Child Neurol. 2005;20:960-4 pubmed
Charrier C, Coronas V, Fombonne J, Roger M, Jean A, Krantic S, et al. Characterization of neural stem cells in the dorsal vagal complex of adult rat by in vivo proliferation labeling and in vitro neurosphere assay. Neuroscience. 2006;138:5-16 pubmed
Copray S, Balasubramaniyan V, Levenga J, de Bruijn J, Liem R, Boddeke E. Olig2 overexpression induces the in vitro differentiation of neural stem cells into mature oligodendrocytes. Stem Cells. 2006;24:1001-10 pubmed
Matsushita T, Amagai Y, Soga T, Terai K, Obinata M, Hashimoto S. A novel oligodendrocyte cell line OLP6 shows the successive stages of oligodendrocyte development: late progenitor, immature and mature stages. Neuroscience. 2005;136:115-21 pubmed
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product information
Catalog Number :
MAB345
Subcategory :
Neuroscience
Product Name :
Anti-O4 Antibody, clone 81
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Host Name :
Mouse
Antigen :
O4
Clone :
81 (also referred to in the literature as mAB O4)
Conjugate :
Purified
Isotype :
IgM
Product Description :
Anti-O4 Antibody, clone 81
Cross Reactivity :
Chicken;Human;Mouse;Rat
Background :
Oligodendrocytes and astrocytes are derived from common precursor cells, glioblasts (Sommer, 1981). O-Antigens are sulfatides, which function as differentiation markers on the surface of oligodendrocytes of the central nervous system. O4 is formed postnatally (Schachner, 1981) and is a marker for cell bodies and processes of oligodendrocytes types I and II (hairy eyeball type). During oligodendrocyte differentiation, O4 occurs in pro-oligodendrocytes, but not in O-2A-progenitor cells. O4 occurs from day 3 onwards in cell cultures of embryonic mouse brain. Anti-O4 can be used in myelination, demyelination and remyelination studies and in regeneration experiments.
ALT Names :
Sulfatide
Immunogen :
Homogenate of white matter of corpus callosum from bovine brain.
Specificity :
Recognizes Oligodendrocyte marker O4. Also reacts with certain galactolipids in sperm (see Additional Information library for list).
Package Size :
50 μg
Uses :
Immunocytochemistry;Immunohistochemistry
Storage :
Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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