APP Antibody, APP 643-695 CT fragment, clone 2.F2.19B4 | EMD Millipore MAB343 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

APP Antibody, APP 643-695 CT fragment, clone 2.F2.19B4

catalog :

MAB343

quantity :

100 μL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2.F2.19B4

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 14

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 3e	Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed publisher
western blot; mouse; 1:5000	Wang D, Kinoshita Y, Kinoshita C, Uo T, Sopher B, Cudaback E, et al. Loss of endophilin-B1 exacerbates Alzheimer's disease pathology. Brain. 2015;138:2005-19 pubmed publisher
	Li J, Chu J, Barrero C, Merali S, Pratico D. Homocysteine exacerbates ?-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles. Ann Neurol. 2014;75:851-63 pubmed publisher
	Liu J, Supnet C, Sun S, Zhang H, Good L, Popugaeva E, et al. The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease. Channels (Austin). 2014;8:230-42 pubmed
	Chakrabarti A, Chatterjee A, Sengupta M, Chattopadhyay P, Mukhopadhyay D. Altered levels of amyloid precursor protein intracellular domain-interacting proteins in Alzheimer disease. Alzheimer Dis Assoc Disord. 2014;28:283-90 pubmed publisher
	Chakrabarti A, Mukhopadhyay D. Novel adaptors of amyloid precursor protein intracellular domain and their functional implications. Genomics Proteomics Bioinformatics. 2012;10:208-16 pubmed publisher
	Raychaudhuri M, Roy K, Das S, Mukhopadhyay D. The N-terminal SH3 domain of Grb2 is required for endosomal localization of A?PP. J Alzheimers Dis. 2012;32:479-93 pubmed publisher
	De Chiara G, Marcocci M, Civitelli L, Argnani R, Piacentini R, Ripoli C, et al. APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells. PLoS ONE. 2010;5:e13989 pubmed publisher
	Raychaudhuri M, Mukhopadhyay D. Grb2-mediated alteration in the trafficking of AbetaPP: insights from Grb2-AICD interaction. J Alzheimers Dis. 2010;20:275-92 pubmed publisher
	Campos Peña V, Tapia Ramírez J, Sanchez Torres C, Meraz Rios M. Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane. J Alzheimers Dis. 2009;18:919-33 pubmed publisher
	Marksteiner J, Humpel C. Beta-amyloid expression, release and extracellular deposition in aged rat brain slices. Mol Psychiatry. 2008;13:939-52 pubmed
	Van Vickle G, Esh C, Kalback W, Patton R, Luehrs D, Kokjohn T, et al. TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation. Biochemistry. 2007;46:10317-27 pubmed
	Yeon S, Jeon Y, Hwang E, Kim T. Effects of peptides derived from BACE1 catalytic domain on APP processing. Peptides. 2007;28:838-44 pubmed
	Gatewood J, Morgan M, Eaton M, McNamara I, Stevens L, Macbeth A, et al. Motherhood mitigates aging-related decrements in learning and memory and positively affects brain aging in the rat. Brain Res Bull. 2005;66:91-8 pubmed

product information

Catalog Number :

MAB343

Subcategory :

Neuroscience

Product Name :

Anti-APP Antibody, APP 643-695 CT fragment, clone 2.F2.19B4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P05067

Host Name :

Mouse

Antigen :

APP

Clone :

2.F2.19B4

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-APP Antibody, APP 643-695 CT fragment, clone 2.F2.19B4

Cross Reactivity :

Human;Rat

ALT Names :

APP; Jonas clone

Immunogen :

Carboxyl fragment of APP 643-695 / Jonas.

Specificity :

Reacts with intact full-length Alzheimer precursor protein (APP) and selectively with the cytoplasmic carboxyl fragment of APP 643-695. Epitope has reportedly been mapped in this paper http://www.impub.co.uk/abs/W386.html

Package Size :

100 μL

Uses :

Immunohistochemistry (Paraffin);Western Blotting

Storage :

Maintain lyophilized material at +2–8°C for up to 12 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.