This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Galactocerebroside Antibody, clone mGalC
catalog :
MAB342
quantity :
50 μg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
mGalc
reactivity :
Burton's mouthbrooder, human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, chromatin immunoprecipitation, immunohistochemistry - frozen section, immunohistochemistry - free floating section, other
citations: 50
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; human; loading ...; fig 5a
Allende M, Cook E, Larman B, Nugent A, Brady J, Golebiowski D, et al. Cerebral organoids derived from Sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation. J Lipid Res. 2018;59:550-563 pubmed publisher
  • immunocytochemistry; rat; loading ...; fig s2c
Ercan E, Han J, Di Nardo A, Winden K, Han M, Hoyo L, et al. Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex. J Exp Med. 2017;214:681-697 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:100; loading ...; fig 7
Cudré Cung H, Zavadakova P, Do Vale Pereira S, Remacle N, Henry H, Ivanisevic J, et al. Ammonium accumulation is a primary effect of 2-methylcitrate exposure in an in vitro model for brain damage in methylmalonic aciduria. Mol Genet Metab. 2016;119:57-67 pubmed publisher
  • immunohistochemistry - free floating section; human; fig 2
Fernández Nogales M, Santos Galindo M, Merchán Rubira J, Hoozemans J, Rábano A, Ferrer I, et al. Tau-positive nuclear indentations in P301S tauopathy mice. Brain Pathol. 2017;27:314-322 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; fig s13a
Nagao M, Ogata T, Sawada Y, Gotoh Y. Zbtb20 promotes astrocytogenesis during neocortical development. Nat Commun. 2016;7:11102 pubmed publisher
  • immunocytochemistry; rat; 1:50
Liu R, Wang Z, Gou L, Xu H. A cortical astrocyte subpopulation inhibits axon growth in vitro and in vivo. Mol Med Rep. 2015;12:2598-606 pubmed publisher
  • immunocytochemistry; rat; 1:500
Göttle P, Sabo J, Heinen A, Venables G, Torres K, Tzekova N, et al. Oligodendroglial maturation is dependent on intracellular protein shuttling. J Neurosci. 2015;35:906-19 pubmed publisher
  • other; mouse; fig 5
Giera S, Deng Y, Luo R, Ackerman S, Mogha A, Monk K, et al. The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun. 2015;6:6121 pubmed publisher
  • immunocytochemistry; mouse; fig 7
Pooya S, Liu X, Kumar V, Anderson J, Imai F, Zhang W, et al. The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism. Nat Commun. 2014;5:4993 pubmed publisher
  • immunocytochemistry; human; 1:200
Chou C, Sinden J, Couraud P, Modo M. In vitro modeling of the neurovascular environment by coculturing adult human brain endothelial cells with human neural stem cells. PLoS ONE. 2014;9:e106346 pubmed publisher
  • immunocytochemistry; mouse; 1:200
Chucair Elliott A, Conrady C, Zheng M, Kroll C, Lane T, Carr D. Microglia-induced IL-6 protects against neuronal loss following HSV-1 infection of neural progenitor cells. Glia. 2014;62:1418-34 pubmed publisher
  • immunocytochemistry; human
Nguyen H, Nekanti U, Haus D, Funes G, Moreno D, Kamei N, et al. Induction of early neural precursors and derivation of tripotent neural stem cells from human pluripotent stem cells under xeno-free conditions. J Comp Neurol. 2014;522:2767-83 pubmed publisher
  • immunohistochemistry; mouse; 1:1000
Maire C, Ramkissoon S, Hayashi M, Haidar S, Ramkissoon L, diTomaso E, et al. Pten loss in Olig2 expressing neural progenitor cells and oligodendrocytes leads to interneuron dysplasia and leukodystrophy. Stem Cells. 2014;32:313-26 pubmed publisher
  • immunocytochemistry; human; 1:200
Wolpert F, Tritschler I, Steinle A, Weller M, Eisele G. A disintegrin and metalloproteinases 10 and 17 modulate the immunogenicity of glioblastoma-initiating cells. Neuro Oncol. 2014;16:382-91 pubmed publisher
  • immunocytochemistry; mouse
Lin C, Lee D, Chang H, Chiu I, Hsu C. Single-cell enzyme-free dissociation of neurospheres using a microfluidic chip. Anal Chem. 2013;85:11920-8 pubmed publisher
  • immunohistochemistry; mouse; 1:250
Momcilovic O, Liu Q, Swistowski A, Russo Tait T, Zhao Y, Rao M, et al. Genome wide profiling of dopaminergic neurons derived from human embryonic and induced pluripotent stem cells. Stem Cells Dev. 2014;23:406-20 pubmed publisher
  • immunocytochemistry; mouse; 1:300
Azari H. Isolation and enrichment of defined neural cell populations from heterogeneous neural stem cell progeny. Methods Mol Biol. 2013;1059:95-106 pubmed publisher
  • western blot; human; 1:2000
Kao C, Hsu Y, Liu J, Lee D, Chung Y, Chiu I. The mood stabilizer valproate activates human FGF1 gene promoter through inhibiting HDAC and GSK-3 activities. J Neurochem. 2013;126:4-18 pubmed publisher
  • immunocytochemistry; rat
Pendleton J, Shamblott M, Gary D, Belegu V, Hurtado A, Malone M, et al. Chondroitin sulfate proteoglycans inhibit oligodendrocyte myelination through PTP?. Exp Neurol. 2013;247:113-21 pubmed publisher
  • immunocytochemistry; Burton's mouthbrooder; 1:100
Mack A, Tiedemann K. Cultures of astroglial cells derived from brain of adult cichlid fish. J Neurosci Methods. 2013;212:269-75 pubmed publisher
  • chromatin immunoprecipitation; human
Darbinyan A, Kaminski R, White M, Darbinian Sarkissian N, Khalili K. Polyomavirus JC infection inhibits differentiation of oligodendrocyte progenitor cells. J Neurosci Res. 2013;91:116-27 pubmed publisher
  • immunohistochemistry; rat; 1:500
Peluffo H, Foster E, Ahmed S, Lago N, Hutson T, Moon L, et al. Efficient gene expression from integration-deficient lentiviral vectors in the spinal cord. Gene Ther. 2013;20:645-57 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200
Shimada I, LeComte M, Granger J, Quinlan N, Spees J. Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after stroke. J Neurosci. 2012;32:7926-40 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:200
Bøttger P, Tracz Z, Heuck A, Nissen P, Romero Ramos M, Lykke Hartmann K. Distribution of Na/K-ATPase alpha 3 isoform, a sodium-potassium P-type pump associated with rapid-onset of dystonia parkinsonism (RDP) in the adult mouse brain. J Comp Neurol. 2011;519:376-404 pubmed publisher
  • immunocytochemistry; mouse; 1:200
Gritti A, Dal Molin M, Foroni C, Bonfanti L. Effects of developmental age, brain region, and time in culture on long-term proliferation and multipotency of neural stem cell populations. J Comp Neurol. 2009;517:333-49 pubmed publisher
Zhou D, Alver B, Li S, Hlady R, Thompson J, Schroeder M, et al. Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues. Genome Biol. 2018;19:43 pubmed publisher
González Fernández E, Jeong H, Fukaya M, Kim H, Khawaja R, Srivastava I, et al. PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling. elife. 2018;7: pubmed publisher
Saab A, Tzvetavona I, Trevisiol A, Baltan S, Dibaj P, Kusch K, et al. Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism. Neuron. 2016;91:119-32 pubmed publisher
Mellai M, Piazzi A, Casalone C, Grifoni S, Melcarne A, Annovazzi L, et al. Astroblastoma: beside being a tumor entity, an occasional phenotype of astrocytic gliomas?. Onco Targets Ther. 2015;8:451-60 pubmed publisher
Steiner J, Martins de Souza D, Schiltz K, Sarnyai Z, Westphal S, Isermann B, et al. Clozapine promotes glycolysis and myelin lipid synthesis in cultured oligodendrocytes. Front Cell Neurosci. 2014;8:384 pubmed publisher
Carr F, Géranton S, Hunt S. Descending controls modulate inflammatory joint pain and regulate CXC chemokine and iNOS expression in the dorsal horn. Mol Pain. 2014;10:39 pubmed publisher
Thomas A, Seidlits S, Goodman A, Kukushliev T, Hassani D, Cummings B, et al. Sonic hedgehog and neurotrophin-3 increase oligodendrocyte numbers and myelination after spinal cord injury. Integr Biol (Camb). 2014;6:694-705 pubmed publisher
Verginelli F, Perin A, Dali R, Fung K, Lo R, Longatti P, et al. Transcription factors FOXG1 and Groucho/TLE promote glioblastoma growth. Nat Commun. 2013;4:2956 pubmed publisher
Moussa S, Jenabian M, Gody J, Léal J, Gresenguet G, Le Faou A, et al. Adaptive HIV-specific B cell-derived humoral immune defenses of the intestinal mucosa in children exposed to HIV via breast-feeding. PLoS ONE. 2013;8:e63408 pubmed publisher
Swistowski A, Zeng X. Scalable production of transplantable dopaminergic neurons from hESCs and iPSCs in xeno-free defined conditions. Curr Protoc Stem Cell Biol. 2012;Chapter 2:Unit2D.12 pubmed publisher
Vernon A, Smith E, Stevanato L, Modo M. Selective activation of metabotropic glutamate receptor 7 induces inhibition of cellular proliferation and promotes astrocyte differentiation of ventral mesencephalon human neural stem/progenitor cells. Neurochem Int. 2011;59:421-31 pubmed publisher
Siebzehnrubl F, Vedam Mai V, Azari H, Reynolds B, Deleyrolle L. Isolation and characterization of adult neural stem cells. Methods Mol Biol. 2011;750:61-77 pubmed publisher
Swistowski A, Peng J, Liu Q, Mali P, Rao M, Cheng L, et al. Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions. Stem Cells. 2010;28:1893-904 pubmed publisher
Swistowski A, Peng J, Han Y, Swistowska A, Rao M, Zeng X. Xeno-free defined conditions for culture of human embryonic stem cells, neural stem cells and dopaminergic neurons derived from them. PLoS ONE. 2009;4:e6233 pubmed publisher
Yuki K, Natsume A, Yokoyama H, Kondo Y, Ohno M, Kato T, et al. Induction of oligodendrogenesis in glioblastoma-initiating cells by IFN-mediated activation of STAT3 signaling. Cancer Lett. 2009;284:71-9 pubmed publisher
Pina Oviedo S, Khalili K, Del Valle L. Hypoxia inducible factor-1 alpha activation of the JCV promoter: role in the pathogenesis of progressive multifocal leukoencephalopathy. Acta Neuropathol. 2009;118:235-47 pubmed publisher
De Filippis L, Ferrari D, Rota Nodari L, Amati B, Snyder E, Vescovi A. Immortalization of human neural stem cells with the c-myc mutant T58A. PLoS ONE. 2008;3:e3310 pubmed publisher
Sher F, Rössler R, Brouwer N, Balasubramaniyan V, Boddeke E, Copray S. Differentiation of neural stem cells into oligodendrocytes: involvement of the polycomb group protein Ezh2. Stem Cells. 2008;26:2875-83 pubmed publisher
Tracy E, Aldrink J, Panosian J, Beam D, Thacker J, Reese M, et al. Isolation of oligodendrocyte-like cells from human umbilical cord blood. Cytotherapy. 2008;10:518-25 pubmed publisher
Gehrmann M, Liebisch G, Schmitz G, Anderson R, Steinem C, De Maio A, et al. Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3. PLoS ONE. 2008;3:e1925 pubmed publisher
De Filippis L, Lamorte G, Snyder E, Malgaroli A, Vescovi A. A novel, immortal, and multipotent human neural stem cell line generating functional neurons and oligodendrocytes. Stem Cells. 2007;25:2312-21 pubmed
Kumar R, Maher D, Herzberg M, Southern P. Expression of HIV receptors, alternate receptors and co-receptors on tonsillar epithelium: implications for HIV binding and primary oral infection. Virol J. 2006;3:25 pubmed
Lin D, Wu J, Holstein D, Upadhyay G, Rourk W, Muller E, et al. Ca2+ signaling, mitochondria and sensitivity to oxidative stress in aging astrocytes. Neurobiol Aging. 2007;28:99-111 pubmed
Matsushita T, Amagai Y, Soga T, Terai K, Obinata M, Hashimoto S. A novel oligodendrocyte cell line OLP6 shows the successive stages of oligodendrocyte development: late progenitor, immature and mature stages. Neuroscience. 2005;136:115-21 pubmed
Hu Q, Frank I, Williams V, Santos J, Watts P, Griffin G, et al. Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue. J Exp Med. 2004;199:1065-75 pubmed
product information
Catalog Number :
MAB342
Subcategory :
Neuroscience
Product Name :
Anti-Galactocerebroside Antibody, clone mGalC
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Host Name :
Mouse
Antigen :
Galactocerebroside
Clone :
mGalC
Conjugate :
Purified
Isotype :
IgG3
Product Description :
Anti-Galactocerebroside Antibody, clone mGalC
Cross Reactivity :
Chicken;Bovine;Human;Mouse;Rat;Rabbit
Background :
Galactocerebroside (GalC) is a major galactosphingolipid of myelin which plays a role in myelination. GalC is a very useful, specific marker for oligodendroglial lineage.
ALT Names :
GalC;Galactoceramide
Immunogen :
Synaptic plasma membranes from bovine hippocampus. Ranscht, B. et al. PNAS 79(8):2709-2713 (1982)
Specificity :
Galactocerebroside (GalC), sulfatide, psychosine and other galactolipids. Cross-reacts with the sulfatide ester of GalC, but to a 16-fold lesser extent. No cross-reactivity with sphingosine, ceramide, mixed ganglioside or glucocerebroside. Binds specifically with oligodendrocytes and Schwann cells.
Package Size :
50 μg
Uses :
ELISA;Immunocytochemistry;Immunohistochemistry;Western Blotting
Storage :
Stable for 1 year at -20ºC from date of receipt.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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