This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
GABA A Receptor β 2,3 Chain Antibody, clone BD17
catalog :
MAB341
quantity :
100 μg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
BD17
reactivity :
human, mouse, rat, chicken, bovine
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section, immunohistochemistry - free floating section
citations: 47
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; rat; 1:1000; loading ...; fig 2a
Lorenzo L, Godin A, Ferrini F, Bachand K, Plasencia Fernandez I, Labrecque S, et al. Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain. Nat Commun. 2020;11:869 pubmed publisher
  • western blot; human; loading ...; fig e2c
Laverty D, Desai R, Uchański T, Masiulis S, Stec W, Malinauskas T, et al. Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer. Nature. 2019;565:516-520 pubmed publisher
  • western blot; mouse; loading ...; tbl 1
Li J, Casteels T, Frogne T, Ingvorsen C, Honore C, Courtney M, et al. Artemisinins Target GABAA Receptor Signaling and Impair ? Cell Identity. Cell. 2017;168:86-100.e15 pubmed publisher
  • immunocytochemistry; rat; 1:500; fig 8
Liu Z, Ding J, Yang Q, Song H, Chen X, Xu Y, et al. Early developmental bisphenol-A exposure sex-independently impairs spatial memory by remodeling hippocampal dendritic architecture and synaptic transmission in rats. Sci Rep. 2016;6:32492 pubmed publisher
  • immunohistochemistry; chicken; 1:200; loading ...; fig 6b
Niederleitner B, Gutierrez Ibanez C, Krabichler Q, Weigel S, Luksch H. A novel relay nucleus between the inferior colliculus and the optic tectum in the chicken (Gallus gallus). J Comp Neurol. 2017;525:513-534 pubmed publisher
  • immunocytochemistry; mouse; 10 ug/ml; fig 1
  • ELISA; mouse; fig 3
Brown L, Nicholson M, Arama J, Mercer A, Thomson A, Jovanovic J. ?-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains. J Biol Chem. 2016;291:13926-42 pubmed publisher
  • western blot; mouse; fig 7
Frank R, Komiyama N, Ryan T, Zhu F, O Dell T, Grant S. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation. Nat Commun. 2016;7:11264 pubmed publisher
  • immunohistochemistry; rat; 1:400; loading ...; fig 7
  • western blot; rat; 1:500; loading ...; fig 1a
Grüter T, Wiescholleck V, Dubovyk V, Aliane V, Manahan Vaughan D. Altered neuronal excitability underlies impaired hippocampal function in an animal model of psychosis. Front Behav Neurosci. 2015;9:117 pubmed publisher
  • western blot; rat; 1:1000
Gao W, Yu L, Liu Y, Wang Y, Huang X. Mechanism of GABA receptors involved in spasticity inhibition induced by transcranial magnetic stimulation following spinal cord injury. J Huazhong Univ Sci Technolog Med Sci. 2015;35:241-247 pubmed publisher
  • western blot; rat; 1:500; tbl 1
Van Skike C, Diaz Granados J, Matthews D. Chronic intermittent ethanol exposure produces persistent anxiety in adolescent and adult rats. Alcohol Clin Exp Res. 2015;39:262-71 pubmed publisher
  • western blot; rat; 1:1000
Almeida Suhett C, Prager E, Pidoplichko V, Figueiredo T, Marini A, Li Z, et al. Reduced GABAergic inhibition in the basolateral amygdala and the development of anxiety-like behaviors after mild traumatic brain injury. PLoS ONE. 2014;9:e102627 pubmed publisher
  • immunocytochemistry; human
Ohkawa T, Satake S, Yokoi N, Miyazaki Y, Ohshita T, Sobue G, et al. Identification and characterization of GABA(A) receptor autoantibodies in autoimmune encephalitis. J Neurosci. 2014;34:8151-63 pubmed publisher
  • western blot; human
Dostalova Z, Zhou X, Liu A, Zhang X, Zhang Y, Desai R, et al. Human ?1?3?2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state. Protein Sci. 2014;23:157-66 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:200
Seese R, Chen L, Cox C, Schulz D, Babayan A, Bunney W, et al. Synaptic abnormalities in the infralimbic cortex of a model of congenital depression. J Neurosci. 2013;33:13441-8 pubmed publisher
  • immunohistochemistry; mouse; fig 4
Dhingra A, Fina M, Neinstein A, Ramsey D, Xu Y, Fishman G, et al. Autoantibodies in melanoma-associated retinopathy target TRPM1 cation channels of retinal ON bipolar cells. J Neurosci. 2011;31:3962-7 pubmed publisher
  • immunocytochemistry; rat
Matsuoka H, Harada K, Endo Y, Warashina A, Doi Y, Nakamura J, et al. Molecular mechanisms supporting a paracrine role of GABA in rat adrenal medullary cells. J Physiol. 2008;586:4825-42 pubmed publisher
  • immunocytochemistry; rat
Brewer G, Boehler M, Jones T, Wheeler B. NbActiv4 medium improvement to Neurobasal/B27 increases neuron synapse densities and network spike rates on multielectrode arrays. J Neurosci Methods. 2008;170:181-7 pubmed publisher
  • immunohistochemistry - free floating section; rat; 15 ug/ml
Melone M, Burette A, Weinberg R. Light microscopic identification and immunocytochemical characterization of glutamatergic synapses in brain sections. J Comp Neurol. 2005;492:495-509 pubmed
Nicholson M, Sweeney A, Pekle E, Alam S, Ali A, Duchen M, et al. Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca2+/calcineurin signalling downstream of GABAA receptors. Mol Psychiatry. 2018;23:1851-1867 pubmed publisher
Brady M, Pilli J, Lorenz Guertin J, Das S, Moon C, Graff N, et al. Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling. Neuropharmacology. 2018;128:324-339 pubmed publisher
Huang X, Zhou C, Tian M, Kang J, Shen W, Verdier K, et al. Overexpressing wild-type ?2 subunits rescued the seizure phenotype in Gabrg2+/Q390X Dravet syndrome mice. Epilepsia. 2017;58:1451-1461 pubmed publisher
Arama J, Abitbol K, Goffin D, Fuchs C, Sihra T, Thomson A, et al. GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons. Front Cell Neurosci. 2015;9:290 pubmed publisher
Zeeh C, Mustari M, Hess B, Horn A. Transmitter inputs to different motoneuron subgroups in the oculomotor and trochlear nucleus in monkey. Front Neuroanat. 2015;9:95 pubmed publisher
Niederwanger A, Ciardi C, Tatarczyk T, Khan M, Hermann M, Mittermair C, et al. Postprandial lipemia induces pancreatic α cell dysfunction characteristic of type 2 diabetes: studies in healthy subjects, mouse pancreatic islets, and cultured pancreatic α cells. Am J Clin Nutr. 2014;100:1222-31 pubmed publisher
Gao M, Maynard K, Chokshi V, Song L, Jacobs C, Wang H, et al. Rebound potentiation of inhibition in juvenile visual cortex requires vision-induced BDNF expression. J Neurosci. 2014;34:10770-9 pubmed publisher
Bracamontes J, Li P, Akk G, Steinbach J. Mutations in the main cytoplasmic loop of the GABA(A) receptor ?4 and ? subunits have opposite effects on surface expression. Mol Pharmacol. 2014;86:20-7 pubmed publisher
Ishii A, Kanaumi T, Sohda M, Misumi Y, Zhang B, Kakinuma N, et al. Association of nonsense mutation in GABRG2 with abnormal trafficking of GABAA receptors in severe epilepsy. Epilepsy Res. 2014;108:420-32 pubmed publisher
Pribiag H, Stellwagen D. TNF-? downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors. J Neurosci. 2013;33:15879-93 pubmed publisher
El Idrissi A, Shen C, L Amoreaux W. Neuroprotective role of taurine during aging. Amino Acids. 2013;45:735-50 pubmed publisher
Fuchs C, Abitbol K, Burden J, Mercer A, Brown L, Iball J, et al. GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses. Eur J Neurosci. 2013;38:3146-58 pubmed publisher
Weltzien F, Dimarco S, Protti D, Daraio T, Martin P, Grünert U. Characterization of secretagogin-immunoreactive amacrine cells in marmoset retina. J Comp Neurol. 2014;522:435-55 pubmed publisher
Yuen E, Wei J, Zhong P, Yan Z. Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease. Neurobiol Dis. 2012;46:497-502 pubmed publisher
Sümegi M, Fukazawa Y, Matsui K, Lorincz A, Eyre M, Nusser Z, et al. Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA(A) receptors in cortical pyramidal cells. J Physiol. 2012;590:1517-34 pubmed publisher
Kuczewski N, Fuchs C, Ferrand N, Jovanovic J, Gaiarsa J, Porcher C. Mechanism of GABAB receptor-induced BDNF secretion and promotion of GABAA receptor membrane expression. J Neurochem. 2011;118:533-45 pubmed publisher
Gonzalez Islas C, Chub N, Garcia Bereguiain M, Wenner P. GABAergic synaptic scaling in embryonic motoneurons is mediated by a shift in the chloride reversal potential. J Neurosci. 2010;30:13016-20 pubmed publisher
Wei J, Liu W, Yan Z. Regulation of AMPA receptor trafficking and function by glycogen synthase kinase 3. J Biol Chem. 2010;285:26369-76 pubmed publisher
McDowell K, Hutchinson A, Wong Goodrich S, Presby M, Su D, Rodriguiz R, et al. Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice. J Neurosci. 2010;30:7453-65 pubmed publisher
Braun M, Ramracheya R, Bengtsson M, Clark A, Walker J, Johnson P, et al. Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells. Diabetes. 2010;59:1694-701 pubmed publisher
Goffin D, Ali A, Rampersaud N, Harkavyi A, Fuchs C, Whitton P, et al. Dopamine-dependent tuning of striatal inhibitory synaptogenesis. J Neurosci. 2010;30:2935-50 pubmed publisher
Mizuta K, Xu D, Pan Y, Comas G, Sonett J, Zhang Y, et al. GABAA receptors are expressed and facilitate relaxation in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2008;294:L1206-16 pubmed publisher
Sarro E, Kotak V, Sanes D, Aoki C. Hearing loss alters the subcellular distribution of presynaptic GAD and postsynaptic GABAA receptors in the auditory cortex. Cereb Cortex. 2008;18:2855-67 pubmed publisher
Modirrousta M, Mainville L, Jones B. Dynamic changes in GABAA receptors on basal forebrain cholinergic neurons following sleep deprivation and recovery. BMC Neurosci. 2007;8:15 pubmed
El Idrissi A. Taurine and brain excitability. Adv Exp Med Biol. 2006;583:315-22 pubmed
Matsuno H, Okabe S, Mishina M, Yanagida T, Mori K, Yoshihara Y. Telencephalin slows spine maturation. J Neurosci. 2006;26:1776-86 pubmed
Lilly S, Alvarez F, Tietz E. Synaptic and subcellular localization of A-kinase anchoring protein 150 in rat hippocampal CA1 pyramidal cells: Co-localization with excitatory synaptic markers. Neuroscience. 2005;134:155-63 pubmed
Stellwagen D, Beattie E, Seo J, Malenka R. Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha. J Neurosci. 2005;25:3219-28 pubmed
El Idrissi A, Ding X, Scalia J, Trenkner E, Brown W, Dobkin C. Decreased GABA(A) receptor expression in the seizure-prone fragile X mouse. Neurosci Lett. 2005;377:141-6 pubmed
product information
Catalog Number :
MAB341
Subcategory :
Neuroscience
Product Name :
Anti-GABA A Receptor β 2,3 Chain Antibody, clone BD17
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P47870
Host Name :
Mouse
Antigen :
GABA A Receptor β 2
Clone :
BD17
Conjugate :
Purified
Isotype :
IgG1
Product Description :
Anti-GABA A Receptor β 2,3 Chain Antibody, clone BD17
Cross Reactivity :
Bovine;Human;Mouse;Rat;Monkey;Feline
Background :
Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels that mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs, including barbiturates, anaesthetics and benzodiazepines.
ALT Names :
GABA(A) receptor subunit beta-2;gamma-aminobutyric acid (GABA) A receptor, beta 2;gamma-aminobutyric acid A receptor, beta 2
Immunogen :
Purified GABA/benzodiazepine receptor from bovine cortex
Specificity :
Reacts with the β-chain of the GABAA receptor.
Package Size :
100 μg
Uses :
Immunohistochemistry;Immunoprecipitation;Western Blotting
Storage :
Stable for 1 year at -20ºC from date of receipt.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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