Cytokeratin 18 Antibody, clone CK2 (Ascites Free) | EMD Millipore MAB3404-C product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Cytokeratin 18 Antibody, clone CK2 (Ascites Free)

catalog :

MAB3404-C

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CK2

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:100; loading ...; fig 1a	Märkl B, Kazik M, Harbeck N, Jakubowicz E, Hoffmann R, Jung T, et al. Impact of uPA/PAI-1 and disseminated cytokeratin-positive cells in breast cancer. BMC Cancer. 2019;19:692 pubmed publisher

product information

Catalog Number :

MAB3404-C

Subcategory :

Cell Signaling

Product Name :

Anti-Cytokeratin 18 Antibody, clone CK2 (Ascites Free)

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P05783

Host Name :

Mouse

Antigen :

KRT18

Clone :

CK2

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-Cytokeratin 18 Antibody, clone CK2 (Ascites Free)

Cross Reactivity :

Human

Background :

Cytokeratin 18, also known as Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, CK-18, Keratin-18, or K18, and encoded by the gene KRT18/CYK18/PIG46, is involved in the uptake of thrombin-anti-thrombin complexes by hepatic cells. When the protein is phosphorylated it plays a role in filament reorganization. Cytokeratin-18 together keratin-8 and IL-6 are involved in skin barrier protection too, and cytokeratin-18 is often complexed with Cytokeratin 8. Cytokeratin-18 is expressed in colon, placenta, liver epithelia and many other tissues. Cytokeratin 18 in epithelial cells is cleaved by caspases during apoptosis to produce apoptotic specific CK-18 fragment that is the basis of many apoptosis detection assays.

ALT Names :

Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18

Immunogen :

Cytoskeletal preparation of HeLa cells expressing human Cytokeratin 18.

Package Size :

100 μg

Uses :

Immunohistochemistry, Western Blotting, Immunofluorescence

Storage :

Stable for 1 year at 2-8°C from date of receipt