Collagen Type III Antibody, clone IE7-D7 | EMD Millipore MAB3392 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Collagen Type III Antibody, clone IE7-D7

catalog :

MAB3392

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1E7-D7

reactivity :

human, rat, chicken

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

citations: 10

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; chicken	Wang L, Uhlig P, Eikenberry E, Robenek H, Bruckner P, Hansen U. Lateral growth limitation of corneal fibrils and their lamellar stacking depend on covalent collagen cross-linking by transglutaminase-2 and lysyl oxidases, respectively. J Biol Chem. 2014;289:921-9 pubmed publisher
	Leyh M, Seitz A, DÃ¼rselen L, Schaumburger J, Ignatius A, Grifka J, et al. Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes. Arthritis Res Ther. 2014;16:453 pubmed publisher
	Leyh M, Seitz A, Dürselen L, Springorum H, Angele P, Ignatius A, et al. Osteoarthritic cartilage explants affect extracellular matrix production and composition in cocultured bone marrow-derived mesenchymal stem cells and articular chondrocytes. Stem Cell Res Ther. 2014;5:77 pubmed publisher
	Buckley M, Evans E, Matuszewski P, Chen Y, Satchel L, Elliott D, et al. Distributions of types I, II and III collagen by region in the human supraspinatus tendon. Connect Tissue Res. 2013;54:374-9 pubmed publisher
	Sahin H, Tholema N, Petersen W, Raschke M, Stange R. Impaired biomechanical properties correlate with neoangiogenesis as well as VEGF and MMP-3 expression during rat patellar tendon healing. J Orthop Res. 2012;30:1952-7 pubmed publisher
	Crapo P, Wang Y. Hydrostatic pressure independently increases elastin and collagen co-expression in small-diameter engineered arterial constructs. J Biomed Mater Res A. 2011;96:673-81 pubmed publisher
	Coulson Thomas V, Gesteira T, Coulson Thomas Y, Vicente C, Tersariol I, Nader H, et al. Fibroblast and prostate tumor cell cross-talk: fibroblast differentiation, TGF-?, and extracellular matrix down-regulation. Exp Cell Res. 2010;316:3207-26 pubmed publisher
	Cheng M, Wang H, Yoshida R, Murray M. Platelets and plasma proteins are both required to stimulate collagen gene expression by anterior cruciate ligament cells in three-dimensional culture. Tissue Eng Part A. 2010;16:1479-89 pubmed publisher
	Uhlig P, Bruckner P, Dittrich R, Ringelstein E, Kuhlenbäumer G, Hansen U. Aberrations of dermal connective tissue in patients with cervical artery dissection (sCAD). J Neurol. 2008;255:340-6 pubmed publisher
	Gavish L, Perez L, Gertz S. Low-level laser irradiation modulates matrix metalloproteinase activity and gene expression in porcine aortic smooth muscle cells. Lasers Surg Med. 2006;38:779-86 pubmed

product information

Catalog Number :

MAB3392

Subcategory :

Cell Structure

Product Name :

Anti-Collagen Type III Antibody, clone IE7-D7

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P02461

Host Name :

Mouse

Antigen :

Collagen Type III

Clone :

1E7-D7

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Collagen Type III Antibody, clone IE7-D7

Cross Reactivity :

Rat;Human

Background :

Type III collagen (also known as COL3A1), which adds structure and strength to connective tissues, is found in many places in the body, especially skin, lung, intestinal walls, and the walls of blood vessels. Collagen type III is initially produced as pro-collagen, a protein consisting of three pro-alpha1(III) chains that form the triple-stranded, rope-like molecule. After being synthesized, the pro-collagen molecule is modified by the cell. Enzymes modify the amino acids lysine and proline in the protein strands by adding chemical groups that are necessary for the strands to form a stable molecule and then later to crosslink to other molecules outside the cell. Other enzymes add sugars to the protein. The type III pro-collagen molecules are released from the cell and are processed by enzymes that clip small segments off either end of the molecules to form mature collagen. The mature collagen molecules assemble into fibrils. Cross-linking between molecules produces a very stable fibril, contributing to collagen's tissue strengthening function.

ALT Names :

collagen, type III, alpha 1;collagen, fetal;Ehlers-Danlos syndrome type IV, autosomal dominant;alpha1 (III) collagen;collagen alpha-1(III) chain

Immunogen :

Human type III collagen (Werkmeister, J.A., et al. 1990).

Specificity :

This antibody detects collagen type III. There is no evidence for cross reactivity with Collagen Types I, V and VI or connective tissue proteins (Elastin, Fibronectin and Laminin) at suggested working concentrations.

Package Size :

100 μg

Uses :

Immunohistochemistry;ELISA;Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt