TIMP-1 Antibody, clone 7-6C1 | EMD Millipore MAB3300 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TIMP-1 Antibody, clone 7-6C1

catalog :

MAB3300

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7-6C1

The same clone is also sold as:

LifeSpan Biosciences: LS-C85460

reactivity :

human, rat

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - frozen section

citations: 10

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; rat	Guerra C, Carla Lara Pereira Y, Issa J, Luiz K, Guimarães E, Gerlach R, et al. Histological, histochemical, and protein changes after induced malocclusion by occlusion alteration of Wistar rats. Biomed Res Int. 2014;2014:563463 pubmed publisher
	Ceron C, Rizzi E, Guimaraes D, Martins Oliveira A, Gerlach R, Tanus Santos J. Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-? and MMPs, and decreases vascular remodeling in renovascular hypertension. Free Radic Biol Med. 2013;65:47-56 pubmed publisher
	Rave Frank M, Malik I, Christiansen H, Naz N, Sultan S, Amanzada A, et al. Rat model of fractionated (2 Gy/day) 60 Gy irradiation of the liver: long-term effects. Radiat Environ Biophys. 2013;52:321-38 pubmed publisher
	Dafnis I, Tzinia A, Tsilibary E, Zannis V, Chroni A. An apolipoprotein E4 fragment affects matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 1 and cytokine levels in brain cell lines. Neuroscience. 2012;210:21-32 pubmed publisher
	Fotopoulos V, Tzinia A, Tzurbakis M, Kalfakakou V, Levidiotou Stefanou S, Georgoulis A. Expression levels of matrix metalloproteinase (MMP)-9 and its specific inhibitor TIMP-1, in septic and aseptic arthritis of the knee. Knee Surg Sports Traumatol Arthrosc. 2012;20:1159-67 pubmed publisher
	Souvenir R, Fathali N, Ostrowski R, Lekic T, Zhang J, Tang J. Tissue inhibitor of matrix metalloproteinase-1 mediates erythropoietin-induced neuroprotection in hypoxia ischemia. Neurobiol Dis. 2011;44:28-37 pubmed publisher
	Tong W, Chen W, Ostrowski R, Ma Q, Souvenir R, Zhang L, et al. Maternal hypoxia increases the activity of MMPs and decreases the expression of TIMPs in the brain of neonatal rats. Dev Neurobiol. 2010;70:182-94 pubmed publisher
	Castro M, Rizzi E, Prado C, Rossi M, Tanus Santos J, Gerlach R. Imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinases in hypertensive vascular remodeling. Matrix Biol. 2010;29:194-201 pubmed publisher
	Pascal L, Goo Y, Vêncio R, Page L, Chambers A, Liebeskind E, et al. Gene expression down-regulation in CD90+ prostate tumor-associated stromal cells involves potential organ-specific genes. BMC Cancer. 2009;9:317 pubmed publisher
	Rastogi S, Mishra S, Zaca V, Alesh I, Gupta R, Goldstein S, et al. Effect of long-term monotherapy with the aldosterone receptor blocker eplerenone on cytoskeletal proteins and matrix metalloproteinases in dogs with heart failure. Cardiovasc Drugs Ther. 2007;21:415-22 pubmed

product information

Catalog Number :

MAB3300

Subcategory :

Cell Structure

Product Name :

Anti-TIMP-1 Antibody, clone 7-6C1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P01033

Host Name :

Mouse

Antigen :

TIMP-1

Clone :

7-6C1

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-TIMP-1 Antibody, clone 7-6C1

Cross Reactivity :

Bovine;Human;Rat

Background :

Tissue Inhibitors of Metalloproteinases (TIMPs) inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-1 and TIMP-2 have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-1 forms a complex of 1:1 stoichiometry with activated interstitial collagenase, activated stromelysin, active form of 72 kDa type IV collagenase (also known as MMP-2 or gelatinase A), and latent and active forms 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-1 levels in quiescent cells and tissues is low (pg/ml), and stimulation with the phorbol ester TPA or protein concentration is often needed to visualize protein bands. In addition, cell types differ greatly in the amount of TIMP-1 produced.

ALT Names :

Tissue Inhibitor of Metalloproteinase-1

Immunogen :

Bovine TIMP-1

Specificity :

MAB3300 is a purified mouse monoclonal antibody to bovine tissue inhibitor of metalloproteinases-1 (bovine TIMP-1). The antibody specifically reacts with bovine TIMP-1 and cross-reacts with human and rat TIMP-1, but not with mouse TIMP-1. By western blot the antibody recognizes a glycoprotein of 28.5 kDa, which is identified as tissue inhibitor of metalloproteinases-1 (TIMP-1).

Package Size :

100 µg

Uses :

ELISA;Western Blotting;Immunohistochemistry

Storage :

Maintain frozen at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze-thaw cycles.