Cytokeratin 19 Antibody, clone RCK108 | EMD Millipore MAB3238 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Cytokeratin 19 Antibody, clone RCK108

catalog :

MAB3238

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

RCK108

The same clone is also sold as:

Novus Biologicals: NBP1-97712
Invitrogen: MA1-06329
Abnova: MAB3529, MAB16233
Santa Cruz Biotechnology: sc-53003
OriGene: DM188, DM188P
LifeSpan Biosciences: LS-C87911, LS-C22684, LS-B7172, LS-C87912
Dako: M0888

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 13

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 3b	Bandeira F, Goh T, Setiawan M, Yam G, Mehta J. Cellular therapy of corneal epithelial defect by adipose mesenchymal stem cell-derived epithelial progenitors. Stem Cell Res Ther. 2020;11:14 pubmed publisher
western blot; human; 1:2000; fig 4	Subhasitanont P, Chokchaichamnankit D, Chiablaem K, Keeratichamroen S, Ngiwsara L, Paricharttanakul N, et al. Apigenin inhibits growth and induces apoptosis in human cholangiocarcinoma cells. Oncol Lett. 2017;14:4361-4371 pubmed publisher
western blot; human	Evans C, Rosser R, Waby J, Noirel J, Lai D, Wright P, et al. Reduced keratin expression in colorectal neoplasia and associated fields is reversible by diet and resection. BMJ Open Gastroenterol. 2015;2:e000022 pubmed publisher
immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 2 immunocytochemistry; human; 1:500; loading ...; fig 4	Abou Kheir W, Eid A, El Merahbi R, Assaf R, Daoud G. A Unique Expression of Keratin 14 in a Subset of Trophoblast Cells. PLoS ONE. 2015;10:e0139939 pubmed publisher
	Pontiggia L, Biedermann T, Böttcher Haberzeth S, Oliveira C, Braziulis E, Klar A, et al. De novo epidermal regeneration using human eccrine sweat gland cells: higher competence of secretory over absorptive cells. J Invest Dermatol. 2014;134:1735-1742 pubmed publisher
	Krings G, Can B, Ferrell L. Aberrant centrizonal features in chronic hepatic venous outflow obstruction: centrilobular mimicry of portal-based disease. Am J Surg Pathol. 2014;38:205-14 pubmed publisher
	Aljitawi O, Xiao Y, Zhang D, Stehno Bittel L, Garimella R, Hopkins R, et al. Generating CK19-positive cells with hair-like structures from Wharton's jelly mesenchymal stromal cells. Stem Cells Dev. 2013;22:18-26 pubmed publisher
	O CONNELL K, Prencipe M, O Neill A, Corcoran C, Rani S, Henry M, et al. The use of LC-MS to identify differentially expressed proteins in docetaxel-resistant prostate cancer cell lines. Proteomics. 2012;12:2115-26 pubmed publisher
	Mahalingam M, Richards J, Selim M, Muzikansky A, Hoang M. An immunohistochemical comparison of cytokeratin 7, cytokeratin 15, cytokeratin 19, CAM 5.2, carcinoembryonic antigen, and nestin in differentiating porocarcinoma from squamous cell carcinoma. Hum Pathol. 2012;43:1265-72 pubmed publisher
	Varga I, Hutóczki G, Szemcsák C, Zahuczky G, Toth J, Adamecz Z, et al. Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma. Pathol Oncol Res. 2012;18:413-20 pubmed publisher
	Ren Z, Wang J, Zhu W, Guan Y, Zou C, Chen Z, et al. Spontaneous transformation of adult mesenchymal stem cells from cynomolgus macaques in vitro. Exp Cell Res. 2011;317:2950-7 pubmed publisher
	Bleijerveld O, Brakenhoff R, Schaaij Visser T, Damen J, Altelaar A, Heck A, et al. Protein signatures associated with tumor cell dissemination in head and neck cancer. J Proteomics. 2011;74:558-66 pubmed publisher
	Walker M, Ellis S, Auza M, Patel A, Clark P. The intercellular adhesion molecule, cadherin-10, is a marker for human prostate luminal epithelial cells that is not expressed in prostate cancer. Mod Pathol. 2008;21:85-95 pubmed

product information

Catalog Number :

MAB3238

Subcategory :

Cell Structure

Product Name :

Anti-Cytokeratin 19 Antibody, clone RCK108

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08727

Host Name :

Mouse

Antigen :

Cytokeratin 19

Clone :

RCK108

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Cytokeratin 19 Antibody, clone RCK108

Cross Reactivity :

Human

Background :

Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides. They range in molecular weight from between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8, The individual cytokeratin polypeptides are designated 1-20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. Cytokeratin 19 (molecular mass 40 kD) is a marker of simple epithelia. Cytokeratin 19 has been found in mesothelial and mesothelioma cells, and in ovarian cysts, cystadenomas, and ovarian carcinomas. It has been shown to be present in the basal layer of non-keratinizing stratified squamous epithelia such as the oral cavity and the ectocervix. Cytokeratin 19 has also been found in adenocarcinomas of the lung and in tumor cells of pulmonary metastases. It has been reported that cytokeratin 19 can be found in the ductal cells of normal pancreas and in pancreas cancers. It was found that ductal cells of normal pancreas express a number of cytokeratins including cytokeratin 19, whereas acinar cells of normal pancreas also express numerous cytokeratins but not cytokeratin 19. Thus it is determined that pancreas cancers consistently express certain cytokeratins including cytokeratin 19, as do normal ductal cells, which indicates that pancreas cancers may originate from normal ductal cells.

Immunogen :

Cytoskeletal preparation of T24 cells.

Specificity :

Cytokeratin 19. MAB3238 reacts with glandular epithelial cells and most carcinomas. Does not react with hepatocytes and hepatocarcinoma

Package Size :

100 µg

Uses :

Flow Cytometry;Western Blotting;Immunocytochemistry;Immunohistochemistry (Paraffin)

Storage :

Maintain at -20°C in undiluted aliquots up to 6 months. Avoid repeated freeze/thaw cycles.