TNF Receptor Antibody, extracellular, clone H398 | EMD Millipore MAB3216-100ug product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TNF Receptor Antibody, extracellular, clone H398

catalog :

MAB3216-100ug

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

H398

The same clone is also sold as:

Enzo Life Sciences: ALX-804-200-C100
Bio-Rad: MCA1340XZ, MCA1340T, MCA1340
Invitrogen: MA5-28600, BMS106, 33-0100
LifeSpan Biosciences: LS-C18344, LS-C202635, LS-C139951, LS-C202636, LS-C139952, LS-C18343, LS-C179557, LS-C179558
Beckman Coulter: A22359
Exbio: 12-773-C100, 11-773-C100, 1P-773-T100, 11-773-C025
Abnova: MAB13968
Santa Cruz Biotechnology: sc-52739
MyBioSource: MBS214946
OriGene: SM1185B, SM1185AF, SM1185R, SM1185LE, TA700021, SM1185P, SM1185F
Novus Biologicals: NBP2-37724
Abcam: ab194814

reactivity :

human

application :

western blot, ELISA, immunoprecipitation, flow cytometry, radioimmunoassay

product information

Catalog Number :

MAB3216-100ug

Subcategory :

Inflammation & Immunology

Product Name :

Anti-TNF Receptor Antibody, extracellular, clone H398

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P19438

Host Name :

Mouse

Antigen :

TNF Receptor

Clone :

H398

Conjugate :

Purified

Isotype :

IgG2a

Product Description :

Anti-TNF Receptor Antibody, extracellular, clone H398

Cross Reactivity :

Human

Background :

Tumor necrosis factor receptor superfamily member 1A (TNF-receptor 1 or CD120a) is a receptor for TNFSF2/TNF-alpha. TNF receptor mediates apoptosis and contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain of TNF receptor leads to homotrimerization. Defects in TNF receptor cause tumor necrosis factor receptor-associated periodic syndrome (TRAPS), a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia.

ALT Names :

CD120a; TNF-R1; p55

Immunogen :

Recombinant human tumor necrosis factor receptor type 1

Specificity :

Recognizes an extracellular domain of the 55 kDa human TNF receptor (p55, TNF-R1, CD120a). No binding occurs to the 75 kDa TNF receptor (CD120b). This antibody inhibits the biological activity of both natural and recombinant human TNFa and TNFbthrough competitive inhibition of TNF binding to TNF-R1. MAB3216-100ug shows potent antagonistic activity in in vitro TNF mediated cytotoxicity assays (IC50=12nM; IC50=1.7 mg/mL).

Package Size :

100 µg

Uses :

ELISA;Flow Cytometry;Immunoprecipitation;Radioimmunoassay;Western Blotting

Storage :

Maintain at 2-8°C in undiluted aliquots for short term or -20°C up to one year.