Bcl-XL and BclXs Antibody, clone 7B2.5 | EMD Millipore MAB3121 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Bcl-XL and BclXs Antibody, clone 7B2.5

catalog :

MAB3121

quantity :

50 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7B2.5

The same clone is also sold as:

LifeSpan Biosciences: LS-C149456, LS-C149457, LS-C149455
Santa Cruz Biotechnology: sc-56021
Invitrogen: MA5-28637, MA5-28638, A15375
Novus Biologicals: NBP1-28559
Abnova: MAB3283, MAB5861, MAB5860, MAB5859

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry

product information

Catalog Number :

MAB3121

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Bcl-XL and BclXs Antibody, clone 7B2.5

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q07817

Host Name :

Mouse

Antigen :

Bcl-XL and BclXs

Clone :

7B2.5

Conjugate :

Purified

Isotype :

IgG3

Product Description :

Anti-Bcl-XL and BclXs Antibody, clone 7B2.5

Cross Reactivity :

Human

Immunogen :

Recombinant Bcl-XS.

Specificity :

Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems (Cohen, 1991). It plays a key role in tissue and organ development, as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment (Cohen & Duke, 1992). Bcl-2 and one of its homologues, Bcl-XL, protect cells from apoptosis (Nunez & Clarke, 1994; Cory, 1995), while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis (Oltvai, 1993; Farrow, 1995; Chittenden, 1995; Kiefer, 1995). Bcl-XL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2 (Boise, 1993; Gottschalk, 1994; Gonzalez-Garcia, 1995; Dole, 1995; Shimizu, 1995). In contrast, Bad and Bax inhibit the protective functions of Bcl-XL and Bcl-2, respectively. Although heterodimerization between Bcl-XL, Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-XL and Bcl-2 (Oltvai, 1993; Yin, 1994); other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity Cheng, 1996; Gottschalk, 1996). This antibody recognizes Human Bcl-XL (Mr 29 kDa) and Bcl-Xs (Mr 21 kDa).

Package Size :

50 µg

Uses :

Flow Cytometry;Immunoprecipitation;Western Blotting;Immunohistochemistry

Storage :

Store at 2-8°C for up to 12 months.