Ryanodine Receptor Antibody, clone RYR.1 | EMD Millipore MAB3086 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Ryanodine Receptor Antibody, clone RYR.1

catalog :

MAB3086

quantity :

50 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

RYR.1

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, radioimmunoassay

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:200; fig 4d	Donovan C, Seow H, Royce S, Bourke J, Vlahos R. Alteration of Airway Reactivity and Reduction of Ryanodine Receptor Expression by Cigarette Smoke in Mice. Am J Respir Cell Mol Biol. 2015;53:471-8 pubmed publisher
	Himori K, Abe M, Tatebayashi D, Lee J, Westerblad H, Lanner J, et al. Superoxide dismutase/catalase mimetic EUK-134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension. PLoS ONE. 2017;12:e0169146 pubmed publisher
	Braubach P, Orynbayev M, Andronache Z, Hering T, Landwehrmeyer G, Lindenberg K, et al. Altered Ca(2+) signaling in skeletal muscle fibers of the R6/2 mouse, a model of Huntington's disease. J Gen Physiol. 2014;144:393-413 pubmed publisher
	Attali R, Aharoni S, Treves S, Rokach O, Becker Cohen M, Fellig Y, et al. Variable myopathic presentation in a single family with novel skeletal RYR1 mutation. PLoS ONE. 2013;8:e69296 pubmed publisher
	Caruso N, Herberth B, Bartoli M, Puppo F, Dumonceaux J, Zimmermann A, et al. Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy. PLoS Genet. 2013;9:e1003550 pubmed publisher
	Matesic D, Sidorova T, Burns T, Bell A, Tran P, Ruch R, et al. p38 MAPK activation, JNK inhibition, neoplastic growth inhibition, and increased gap junction communication in human lung carcinoma and Ras-transformed cells by 4-phenyl-3-butenoic acid. J Cell Biochem. 2012;113:269-81 pubmed publisher
	Rederstorff M, Castets P, Arbogast S, Laine J, Vassilopoulos S, Beuvin M, et al. Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy. PLoS ONE. 2011;6:e23094 pubmed publisher
	Schulz J, Palmer N, Steckelberg J, Jones S, Zeece M. Microarray profiling of skeletal muscle sarcoplasmic reticulum proteins. Biochim Biophys Acta. 2006;1764:1429-35 pubmed
	Matesic D, Abifadel D, Garcia E, Jann M. Effect of thioridazine on gap junction intercellular communication in connexin 43-expressing cells. Cell Biol Toxicol. 2006;22:257-68 pubmed
	Matesic D, Villio K, Folse S, Garcia E, Cutler S, Cutler H. Inhibition of cytokinesis and akt phosphorylation by chaetoglobosin K in ras-transformed epithelial cells. Cancer Chemother Pharmacol. 2006;57:741-54 pubmed
	Zheng Y, Wang Q, Rathore R, Zhang W, Mazurkiewicz J, Sorrentino V, et al. Type-3 ryanodine receptors mediate hypoxia-, but not neurotransmitter-induced calcium release and contraction in pulmonary artery smooth muscle cells. J Gen Physiol. 2005;125:427-40 pubmed

product information

Catalog Number :

MAB3086

Subcategory :

Neuroscience

Product Name :

Anti-Ryanodine Receptor Antibody, clone RYR.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P21817

Host Name :

Mouse

Antigen :

Ryanodine Receptor

Clone :

RYR.1

Conjugate :

Purified

Isotype :

IgG2b

Product Description :

Anti-Ryanodine Receptor Antibody, clone RYR.1

Cross Reactivity :

Bovine;Canine;Human;Mouse;Pig;Rat

Immunogen :

Short synthetic polypeptide corresponding to the c-terminal domain of the ryanodine receptor.

Specificity :

Reacts with the C-terminus cytoplasmic domain of ryanodine receptor. Ryanodine receptors have been shown to play critical roles in the intracellular Ca2+ signaling occurring during cell activation in muscle cells and non-muscle cells. MAB3086 reacts with ryanodine receptor (MW approx. 500kDa) isolated from a variety of cell types (e.g. lymphocytes, macrophages, granulocytes, fibroblasts, epithelial, endothelial cells, skeletal muscle, cardiac muscle and brain tissues).

Package Size :

50 µg

Uses :

ELISA;Flow Cytometry;Immunocytochemistry;Immunohistochemistry;Immunoprecipitation;Radioimmunoassay;Western Blotting

Storage :

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.