Beta-parvin Antibody, clone 11A5 | EMD Millipore MAB2620 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Beta-parvin Antibody, clone 11A5

catalog :

MAB2620

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

11A5

reactivity :

hamsters, human

application :

western blot, immunocytochemistry

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; hamsters; 1 ug/ml	Honda S, Shirotani Ikejima H, Tadokoro S, Tomiyama Y, Miyata T. The integrin-linked kinase-PINCH-parvin complex supports integrin ?IIb?3 activation. PLoS ONE. 2013;8:e85498 pubmed publisher
	Ubhi K, Rockenstein E, Mante M, Inglis C, Adame A, Patrick C, et al. Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factors. J Neurosci. 2010;30:6236-46 pubmed publisher
	Ubhi K, Lee P, Adame A, Inglis C, Mante M, Rockenstein E, et al. Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy. J Neurosci Res. 2009;87:2728-39 pubmed publisher

product information

Catalog Number :

MAB2620

Subcategory :

Cell Structure

Product Name :

Anti-Beta-parvin Antibody, clone 11A5

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9HBI1

Host Name :

Mouse

Antigen :

Beta-parvin

Clone :

11A5

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-Beta-parvin Antibody, clone 11A5

Cross Reactivity :

Human

Background :

Beta-parvin, also known as affixin, is a focal adhesion protein belonging to a family of ILK-binding proteins that contain tandem calponin homolog domains. Along with Alpha-parvin, Beta-parvin is one of the most widely researched and characterized members of this family. These two proteins interact with the ILK kinase domain in a way that is mutually exclusive and regulates both the activity of the kinase and actin cytoskeleton adhesion. Studies have shown Beta-parvin to be downregulated within human breast cancer cells, and that its expression may influence the progression of breast cancer (Johnstone, 2008). Additional research indicates a critical role for Beta-parvin in the regulation of cardiac contractility when it is in complex with ILK (Hannigan, 2007).

ALT Names :

parvin beta;parvin-beta;affixin

Immunogen :

GST-tagged recombinant protein corresponding to human Beta-parvin.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt