Glypican-1 Antibody, clone 4D1 | EMD Millipore MAB2600 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Glypican-1 Antibody, clone 4D1

catalog :

MAB2600

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4D1

The same clone is also sold as:

Santa Cruz Biotechnology: sc-101827

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:100; fig s69	Rickelt S, Hynes R. Antibodies and methods for immunohistochemistry of extracellular matrix proteins. Matrix Biol. 2018;71-72:10-27 pubmed publisher
	Cheng J, Whitelock J, Poole Warren L. Syndecan-4 is associated with beta-cells in the pancreas and the MIN6 beta-cell line. Histochem Cell Biol. 2012;138:933-44 pubmed publisher

product information

Catalog Number :

MAB2600

Subcategory :

Cell Structure

Product Name :

Anti-Glypican-1 Antibody, clone 4D1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P35052

Host Name :

Mouse

Antigen :

Glypican-1

Clone :

4D1

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Glypican-1 Antibody, clone 4D1

Cross Reactivity :

Human;Rat

Background :

Heparan sulfate proteoglycans (HSPGs) can be divided into general categories of cell-associated forms, including syndecans, glypicans, and secreted extracellular matrix forms, such as perlecan. Glypicans contain six family members to date and are proteins bound to the outer surface of the plasma membrane by a glycosyl-phosphatidylinositol anchor and involved in cellular adhesion and migration and function as accessory molecules for signaling receptors, (Filmus, 2008 & Gui, 2006). Current publications indicate the main function of membrane-attached glypicans is to regulate the signaling of Wnts, Hedgehogs, fibroblast growth factors and bone morphogenetic proteins (BMPs), (Filmus, 2008). Glypican-1 (GPC1) is over-expressed in human gliomas and appears to have a greater capability of promoting FGF-2 signaling in some gliomas versus HSPGs in normal astrocytes. Additional observations suggest that GPC1 can impact the growth of pancreatic cancer cells by attenuating tumor angiogenesis, (Whipple, 2008).

ALT Names :

glypican 1;glypican proteoglycan 1

Immunogen :

Full length recombinant protein.

Specificity :

MAB2600 recognizes glypican-1.

Package Size :

100 μg

Uses :

Immunohistochemistry (Paraffin);Western Blotting

Storage :

Stable for 1 year at 2-8ºC from date of receipt.