Excitatory amino acid transporter 2 Antibody, clone G6 | EMD Millipore MAB2262 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Excitatory amino acid transporter 2 Antibody, clone G6

catalog :

MAB2262

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:1000	Chounlamountry K, Boyer B, Pénalba V, FranÃ§ois Bellan A, Bosler O, Kessler J, et al. Remodeling of glial coverage of glutamatergic synapses in the rat nucleus tractus solitarii after ozone inhalation. J Neurochem. 2015;134:857-64 pubmed publisher
	Sheng L, Stewart T, Yang D, Thorland E, Soltys D, Aro P, et al. Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis. Acta Neuropathol Commun. 2020;8:102 pubmed publisher

product information

Catalog Number :

MAB2262

Subcategory :

Neuroscience

Product Name :

Anti-Excitatory amino acid transporter 2 Antibody, clone G6

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P43004

Host Name :

Mouse

Antigen :

Excitatory amino acid transporter 2

Clone :

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Excitatory amino acid transporter 2 Antibody, clone G6

Cross Reactivity :

Human;Mouse;Rat

Background :

The activity of the main glutamate transporter in the CNS, Excitatory amino acid transporter 2 (also known as GLT1), can be regulated by protein kinase C (PKC). It is known that activation of PKC by phorbol esters promotes the clathrin-dependent internalization of the transporter, followed by its lysosomal degradation. However, the molecular mechanisms that link PKC activation and the internalization of the excitatory amino acid transporter 2 are not fully understood. The internalization process may play a role in the ubiquitylation of lysine residues located in the C-terminal tail of the excitatory amino acid transporter 2. Exposure to PMA increases the ubiquitylation of the excitatory amino acid transporter 2 in transfected cells and in the rat brain, and this ubiquitylated excitatory amino acid transporter 2 accumulates in the intracellular compartment. The activation of PKC induces the ubiquitylation of these C-terminal lysine residues in the Excitatory amino acid transporter 2 and this modification mediates the interaction of the transporter with the endocytic machinery.

ALT Names :

Glutamate/aspartate transporter II;Sodium-dependent glutamate/aspartate transporter 2;Solute carrier family 1 member 2;excitatory amino acid transporter 2;excitotoxic amino acid transporter 2;glial high affinity glutamate transporter;solute carrier family 1 (glial high affinity glutamate transporter), member 2;solute carrier family 1, member 2

Immunogen :

Linear peptide corresponding to the C-terminus of human Excitatory amino acid transporter 2.

Specificity :

This antibody recognizes the C-terminus of Excitatory amino acid transporter 2.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt