Tropomyosin Antibody, clone 15D12.2 | EMD Millipore MAB2254 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tropomyosin Antibody, clone 15D12.2

catalog :

MAB2254

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

15D12.2

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 1b western blot; mouse; loading ...; fig 1b	Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester BeltrÃ¡n J, et al. Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. J Clin Invest. 2017;127:814-829 pubmed publisher
	Thom C, Jobaliya C, Lorenz K, Maguire J, Gagne A, Gadue P, et al. Tropomyosin 1 genetically constrains in vitro hematopoiesis. BMC Biol. 2020;18:52 pubmed publisher

product information

Catalog Number :

MAB2254

Subcategory :

Cell Structure

Product Name :

Anti-Tropomyosin Antibody, clone 15D12.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q923Z2

Host Name :

Mouse

Antigen :

Tropomyosin

Clone :

15D12.2

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-Tropomyosin Antibody, clone 15D12.2

Cross Reactivity :

Mouse;Human;Rat

Background :

Tropomyosins (Tms) are a family of 40 highly conserved protein isoforms resulting from alternative splicing of four different genes during development and that are expressed in numerous cell types. These proteins form coiled-coil heterodimers which bind to actin polymers along the α-helical grove. Tropomyosin’s function varies depending on cell type in which it is expressed. Within muscle, Tms play a role in the regulation of actin-myosin interplay for the purpose of mediating muscle contraction. In non-muscle cells, studies suggest a role in the stabilization of actin filaments, along with protecting actin filaments from the severing action of gelsolin and ADF/cofilin depolymerization. Tms also appear to have a role in the moderation of access to actin for other actin-binding proteins. Tropomyosin has an integral role in maintaining cardiovascular homeostasis. Down-regulation of Tms expression has been observed in tumor cells indicating a possible role for Tms as tumor suppressors.

ALT Names :

tropomyosin 1 (alpha);cardiomyopathy, hypertrophic 3;tropomyosin 1 alpha chain;HTM-alpha;Alpha-tropomyosin;chromosome 15 open reading frame 13;Tropomyosin-1;sarcomeric tropomyosin kappa;alpha tropomyosin

Immunogen :

Linear peptide corresponding to the entire exon 9d of rat Tropomyosin.

Specificity :

The antibody recognizes the entire exon 9d of Tropomyosin.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt