Integrin β1 Antibody, clone 6S6, Azide Free | EMD Millipore MAB2253Z product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Integrin β1 Antibody, clone 6S6, Azide Free

catalog :

MAB2253Z

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6S6

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, blocking or activating experiments

citations: 25

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; fig 5a	Walker L, Hussein H, Akula S. Subcellular fractionation method to study endosomal trafficking of Kaposi's sarcoma-associated herpesvirus. Cell Biosci. 2016;6:1 pubmed publisher
immunohistochemistry; human; tbl 2	Park I, Chung P, Ahn J. Enhancement of Ischemic Wound Healing by Spheroid Grafting of Human Adipose-Derived Stem Cells Treated with Low-Level Light Irradiation. PLoS ONE. 2015;10:e0122776 pubmed publisher
immunocytochemistry; human	Toh Y, Xing J, Yu H. Modulation of integrin and E-cadherin-mediated adhesions to spatially control heterogeneity in human pluripotent stem cell differentiation. Biomaterials. 2015;50:87-97 pubmed publisher
blocking or activating experiments; human; 5 ug/ml; fig 1	Morris E, Assi K, Salh B, Dedhar S. Integrin-linked kinase links dynactin-1/dynactin-2 with cortical integrin receptors to orient the mitotic spindle relative to the substratum. Sci Rep. 2015;5:8389 pubmed publisher
blocking or activating experiments; human	Elloumi Hannachi I, GarcÃa J, Shekeran A, GarcÃa A. Contributions of the integrin Î²1 tail to cell adhesive forces. Exp Cell Res. 2015;332:212-22 pubmed publisher
blocking or activating experiments; human flow cytometry; human immunocytochemistry; human	Kikkawa Y, Ogawa T, Sudo R, Yamada Y, Katagiri F, Hozumi K, et al. The lutheran/basal cell adhesion molecule promotes tumor cell migration by modulating integrin-mediated cell attachment to laminin-511 protein. J Biol Chem. 2013;288:30990-1001 pubmed publisher
	Majkowska I, Shitomi Y, Ito N, Gray N, Itoh Y. Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts. J Biol Chem. 2017;292:6633-6643 pubmed publisher
	Mainou B, Dermody T. Transport to late endosomes is required for efficient reovirus infection. J Virol. 2012;86:8346-58 pubmed publisher
	Kaiser R, Friedrich D, Chavakis E, Bohm M, Friedrich E. Effect of hypoxia on integrin-mediated adhesion of endothelial progenitor cells. J Cell Mol Med. 2012;16:2387-93 pubmed publisher
	Matsumoto S, Kikuchi A. Regulation of focal adhesion dynamics by Wnt5a signaling. Methods Mol Biol. 2012;839:215-27 pubmed publisher
	Djaafri I, Maurice P, Labas V, Vinh J, Lemesle M, Arbeille B, et al. Platelet type III collagen binding protein (TIIICBP) presents high biochemical and functional similarities with kindlin-3. Biochimie. 2012;94:416-26 pubmed publisher
	Ihara Y, Inai Y, Ikezaki M. Alteration of integrin-dependent adhesion and signaling in EMT-like MDCK cells established through overexpression of calreticulin. J Cell Biochem. 2011;112:2518-28 pubmed publisher
	Ratzinger S, Grassel S, Dowejko A, Reichert T, Bauer R. Induction of type XVI collagen expression facilitates proliferation of oral cancer cells. Matrix Biol. 2011;30:118-25 pubmed publisher
	Mainou B, Dermody T. Src kinase mediates productive endocytic sorting of reovirus during cell entry. J Virol. 2011;85:3203-13 pubmed publisher
	Iizuka S, Kudo Y, Yoshida M, Tsunematsu T, Yoshiko Y, Uchida T, et al. Ameloblastin regulates osteogenic differentiation by inhibiting Src kinase via cross talk between integrin beta1 and CD63. Mol Cell Biol. 2011;31:783-92 pubmed publisher
	Ohga Y, Katagiri F, Takeyama K, Hozumi K, Kikkawa Y, Nishi N, et al. Design and activity of multifunctional fibrils using receptor-specific small peptides. Biomaterials. 2009;30:6731-8 pubmed publisher
	Lehembre F, Yilmaz M, Wicki A, Schomber T, Strittmatter K, Ziegler D, et al. NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin. EMBO J. 2008;27:2603-15 pubmed publisher
	Somanath P, Kandel E, Hay N, Byzova T. Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly. J Biol Chem. 2007;282:22964-76 pubmed
	Abraham L, Dice J, Lee K, Kaplan D. Phagocytosis and remodeling of collagen matrices. Exp Cell Res. 2007;313:1045-55 pubmed
	Lallier T, Miner Q, Sonnier J, Spencer A. A simple cell motility assay demonstrates differential motility of human periodontal ligament fibroblasts, gingival fibroblasts, and pre-osteoblasts. Cell Tissue Res. 2007;328:339-54 pubmed
	Xie C, Alcaide P, Geisbrecht B, Schneider D, Herrmann M, Preissner K, et al. Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus. J Exp Med. 2006;203:985-94 pubmed
	Maginnis M, Forrest J, Kopecky Bromberg S, Dickeson S, Santoro S, Zutter M, et al. Beta1 integrin mediates internalization of mammalian reovirus. J Virol. 2006;80:2760-70 pubmed
	Heng E, Huang Y, Black S, Trackman P. CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins. J Cell Biochem. 2006;98:409-20 pubmed
	Chavakis E, Aicher A, Heeschen C, Sasaki K, Kaiser R, El Makhfi N, et al. Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells. J Exp Med. 2005;201:63-72 pubmed
	Koivunen E, Ranta T, Annila A, Taube S, Uppala A, Jokinen M, et al. Inhibition of beta(2) integrin-mediated leukocyte cell adhesion by leucine-leucine-glycine motif-containing peptides. J Cell Biol. 2001;153:905-16 pubmed

product information

Catalog Number :

MAB2253Z

Subcategory :

Cell Structure

Product Name :

Anti-Integrin β1 Antibody, clone 6S6, Azide Free

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P05556

Host Name :

Mouse

Antigen :

Integrin β1

Clone :

6S6

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Integrin β1 Antibody, clone 6S6, Azide Free

Cross Reactivity :

Human

Background :

Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression.

ALT Names :

CD29

Immunogen :

Human synovial cells

Specificity :

Reacts with the human integrin beta1 subunit. Specificity verified by preclearing of beta1in immunoprecipitation, flow cytometry on transfectant cells displaying human beta1 integrin, and reactivity with purified beta1. Similar in behavior and characteristics to antibody clone 3S3 (Wilkins et al., 1996).

Package Size :

100 μg

Uses :

Flow Cytometry;Immunohistochemistry;Immunoprecipitation;Affects Function

Storage :

Maintain 6 months at 4°C, from date of shipment. Do not freeze. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.