Integrin β1 Antibody, clone 6S6 | EMD Millipore MAB2253 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Integrin β1 Antibody, clone 6S6

catalog :

MAB2253

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6S6

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, blocking or activating experiments

citations: 28

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; fig 5a	Walker L, Hussein H, Akula S. Subcellular fractionation method to study endosomal trafficking of Kaposi's sarcoma-associated herpesvirus. Cell Biosci. 2016;6:1 pubmed publisher
blocking or activating experiments; human; 20 ug/ml	Vassena L, Giuliani E, Koppensteiner H, Bolduan S, Schindler M, Doria M. HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+ T Lymphocytes. J Virol. 2015;89:5687-700 pubmed publisher
immunocytochemistry; human; 1:100; fig 6	Kim S, Wen W, Prowse P, Hamilton D. Regulation of matrix remodelling phenotype in gingival fibroblasts by substratum topography. J Cell Mol Med. 2015;19:1183-96 pubmed publisher
blocking or activating experiments; human; 5 ug/ml; fig 1	Morris E, Assi K, Salh B, Dedhar S. Integrin-linked kinase links dynactin-1/dynactin-2 with cortical integrin receptors to orient the mitotic spindle relative to the substratum. Sci Rep. 2015;5:8389 pubmed publisher
blocking or activating experiments; human flow cytometry; human immunocytochemistry; human	Kikkawa Y, Ogawa T, Sudo R, Yamada Y, Katagiri F, Hozumi K, et al. The lutheran/basal cell adhesion molecule promotes tumor cell migration by modulating integrin-mediated cell attachment to laminin-511 protein. J Biol Chem. 2013;288:30990-1001 pubmed publisher
	Van Itallie C, Lidman K, Tietgens A, Anderson J. Newly synthesized claudins but not occludin are added to the basal side of the tight junction. Mol Biol Cell. 2019;30:1406-1424 pubmed publisher
	Majkowska I, Shitomi Y, Ito N, Gray N, Itoh Y. Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts. J Biol Chem. 2017;292:6633-6643 pubmed publisher
	Merilahti P, Tauriainen S, Susi P. Human Parechovirus 1 Infection Occurs via αVβ1 Integrin. PLoS ONE. 2016;11:e0154769 pubmed publisher
	Yen Y, Hsiao J, Jiang S, Chang J, Wang S, Shen Y, et al. Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1. Oncotarget. 2015;6:41837-55 pubmed publisher
	Park S, Yun J, Kim J, Kim K, Cho C, Kim J. Angiopoietin 2 induces pericyte apoptosis via ?3?1 integrin signaling in diabetic retinopathy. Diabetes. 2014;63:3057-68 pubmed publisher
	He J, Sun E, Bujny M, Kim D, Davidson M, Zhuang X. Dual function of CD81 in influenza virus uncoating and budding. PLoS Pathog. 2013;9:e1003701 pubmed publisher
	Hung S, Chiu C, Chen T, Chu C, Huang C, Shyur L, et al. Recombinant viral protein VP1 suppresses HER-2 expression and migration/metastasis of breast cancer. Breast Cancer Res Treat. 2012;136:89-105 pubmed publisher
	Chen C, Chen T, Chen H. Extracellular signal-regulated kinase plays a proapoptotic role in podocytes after reactive oxygen species treatment and inhibition of integrin-extracellular matrix interaction. Exp Biol Med (Maywood). 2012;237:777-83 pubmed publisher
	Chen C, Cheng Y, Hwang J, Chang J, Guh J, Chen H. Cyclin D1 expression in podocytes: regulated by mitogens in collaboration with integrin-extracellular matrix interaction through extracellular signal-regulated kinase. Exp Biol Med (Maywood). 2012;237:516-23 pubmed publisher
	Tabariès S, Dupuy F, Dong Z, Monast A, Annis M, Spicer J, et al. Claudin-2 promotes breast cancer liver metastasis by facilitating tumor cell interactions with hepatocytes. Mol Cell Biol. 2012;32:2979-91 pubmed publisher
	Taherian A, Li X, Liu Y, Haas T. Differences in integrin expression and signaling within human breast cancer cells. BMC Cancer. 2011;11:293 pubmed publisher
	Bockelmann J, Klinkhammer K, von Holst A, Seiler N, Faissner A, Brook G, et al. Functionalization of electrospun poly(?-caprolactone) fibers with the extracellular matrix-derived peptide GRGDS improves guidance of schwann cell migration and axonal growth. Tissue Eng Part A. 2011;17:475-86 pubmed publisher
	Lee D, Li Y, Chang S, Zhou J, Ho H, Chiu J, et al. Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway. J Biol Chem. 2010;285:30-42 pubmed publisher
	Yeh C, Chiu J, Lee C, Lee P, Shih Y, Sun J, et al. Estrogen augments shear stress-induced signaling and gene expression in osteoblast-like cells via estrogen receptor-mediated expression of beta1-integrin. J Bone Miner Res. 2010;25:627-39 pubmed publisher
	Chang S, Chang T, Peng H, Yeh Y, Lee D, Yeh C, et al. BMP-4 induction of arrest and differentiation of osteoblast-like cells via p21 CIP1 and p27 KIP1 regulation. Mol Endocrinol. 2009;23:1827-38 pubmed publisher
	Zhuo Y, Chammas R, Bellis S. Sialylation of beta1 integrins blocks cell adhesion to galectin-3 and protects cells against galectin-3-induced apoptosis. J Biol Chem. 2008;283:22177-85 pubmed publisher
	Fujiwara T, Kawakatsu T, Tayama S, Kobayashi Y, Sugiura N, Kimata K, et al. Hyaluronan-CD44 pathway regulates orientation of mitotic spindle in normal epithelial cells. Genes Cells. 2008;13:759-70 pubmed publisher
	Melchior A, Denys A, Deligny A, Mazurier J, Allain F. Cyclophilin B induces integrin-mediated cell adhesion by a mechanism involving CD98-dependent activation of protein kinase C-delta and p44/42 mitogen-activated protein kinases. Exp Cell Res. 2008;314:616-28 pubmed
	Lee T, Seng S, Li H, Kennel S, Avraham H, Avraham S. Integrin regulation by vascular endothelial growth factor in human brain microvascular endothelial cells: role of alpha6beta1 integrin in angiogenesis. J Biol Chem. 2006;281:40450-60 pubmed
	Chen C, Hwang J, Guh J, Tsai J, Chen H. TGF-beta1 and integrin synergistically facilitate the differentiation of rat podocytes by increasing alpha-smooth muscle actin expression. Transl Res. 2006;148:134-41 pubmed
	Xie C, Alcaide P, Geisbrecht B, Schneider D, Herrmann M, Preissner K, et al. Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus. J Exp Med. 2006;203:985-94 pubmed
	Chavakis E, Aicher A, Heeschen C, Sasaki K, Kaiser R, El Makhfi N, et al. Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells. J Exp Med. 2005;201:63-72 pubmed
	Koivunen E, Ranta T, Annila A, Taube S, Uppala A, Jokinen M, et al. Inhibition of beta(2) integrin-mediated leukocyte cell adhesion by leucine-leucine-glycine motif-containing peptides. J Cell Biol. 2001;153:905-16 pubmed

product information

Catalog Number :

MAB2253

Subcategory :

Cell Structure

Product Name :

Anti-Integrin β1 Antibody, clone 6S6

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P05556

Host Name :

Mouse

Antigen :

Integrin β1

Clone :

6S6

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Integrin β1 Antibody, clone 6S6

Cross Reactivity :

Human

Background :

Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression.

ALT Names :

CD29

Immunogen :

Human synovial cells

Specificity :

Reacts with the human integrin beta1 subunit. Specificity verified by preclearing of beta1in immunoprecipitation, flow cytometry on transfectant cells displaying human beta1 integrin, and reactivity with purified beta1. Similar in behavior and characteristics to antibody clone 3S3 (Wilkins et al., 1996).

Package Size :

100 μg

Uses :

Flow Cytometry;Immunohistochemistry;Immunoprecipitation;Affects Function

Storage :

Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.