Nitrated Tau (Tyr29) Antibody, clone Tau-nY29 | EMD Millipore MAB2244 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Nitrated Tau (Tyr29) Antibody, clone Tau-nY29

catalog :

MAB2244

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Tau-nY29

The same clone is also sold as:

Santa Cruz Biotechnology: sc-66177
BioLegend: 829801, 829804

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, western blot knockout validation

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; 1:500; tbl 1 immunocytochemistry; human; 1:50; tbl 2 western blot; mouse	Ercan E, Eid S, Weber C, Kowalski A, Bichmann M, Behrendt A, et al. A validated antibody panel for the characterization of tau post-translational modifications. Mol Neurodegener. 2017;12:87 pubmed publisher
ELISA; human; loading ...; fig s1a	Ercan Herbst E, Ehrig J, Schöndorf D, Behrendt A, Klaus B, Gomez Ramos B, et al. A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain. Acta Neuropathol Commun. 2019;7:192 pubmed publisher

product information

Catalog Number :

MAB2244

Subcategory :

Neuroscience

Product Name :

Anti-Nitrated Tau (Tyr29) Antibody, clone Tau-nY29

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P10636

Host Name :

Mouse

Antigen :

Nitrated Tau (Tyr29)

Clone :

Tau-nY29

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Nitrated Tau (Tyr29) Antibody, clone Tau-nY29

Cross Reactivity :

Human

Background :

Microtubule Associated Proteins, or MAPs, bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. MAP binding to multimerized tubulin further stabilizes the formation of higher order microtubulin structures. MAP binding to microtubule structures is mediated through phosphorylation through Microtubule Affinity Regulated Kinase (MARK). Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types, Iand II. Type II MAP includes MAP2, MAP4, and tau and is found in nervous tissue. Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains.

ALT Names :

G protein beta1/gamma2 subunit-interacting factor 1;Neurofibrillary tangle protein ;Paired helical filament-tau ;microtubule-associated protein tau ;microtubule-associated protein tau, isoform 4

Immunogen :

KLH conjugated synthetic linear peptide corresponding to the amino acids surrounding and including nitrated Tyr29 of human Tau.

Specificity :

Recognizes nitrated Tau (Tyr29).

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8ºC from date of receipt.