Nitrated Tau (Tyr18) Antibody, clone Tau-nY18 | EMD Millipore MAB2242 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Nitrated Tau (Tyr18) Antibody, clone Tau-nY18

catalog :

MAB2242

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Tau-nY18

The same clone is also sold as:

BioLegend: 829703, 829701

reactivity :

human

application :

western blot

product information

Catalog Number :

MAB2242

Subcategory :

Neuroscience

Product Name :

Anti-Nitrated Tau (Tyr18) Antibody, clone Tau-nY18

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P10636

Host Name :

Mouse

Antigen :

Nitrated Tau (Tyr18)

Clone :

Tau-nY18

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-Nitrated Tau (Tyr18) Antibody, clone Tau-nY18

Cross Reactivity :

Human

Background :

Microtubule Associated Proteins, or MAPs, bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types. Type II MAP includes MAP2, MAP4, and tau and is found in nervous tissue. Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains.

ALT Names :

G protein beta1/gamma2 subunit-interacting factor 1;Neurofibrillary tangle protein ;Paired helical filament-tau ;microtubule-associated protein tau ;microtubule-associated protein tau, isoform 4

Immunogen :

This antibody is generated from a KLH-conjugated synthetic tau peptide corresponding to amino acids surrounding and including the nitro-group on Tyr 18 of human Tau.

Specificity :

This antibody recognizes nitro-group on Tyr 18 of Tau.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Maintain refrigerated at 2-8°C for 1 year from date of receipt.