Syntrophin Antibody, clone 1351 | EMD Millipore MAB2237 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Syntrophin Antibody, clone 1351

catalog :

MAB2237

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1351

The same clone is also sold as:

Abcam: ab11425

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; rat; 1:100; loading ...; fig s3a	Axelsson A, Mahdi T, Nenonen H, Singh T, Hänzelmann S, Wendt A, et al. Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes. Nat Commun. 2017;8:15652 pubmed publisher
	Lien C, Mohanta S, Frontczak Baniewicz M, Swinny J, Zablocka B, Gorecki D. Absence of glial ?-dystrobrevin causes abnormalities of the blood-brain barrier and progressive brain edema. J Biol Chem. 2012;287:41374-85 pubmed publisher

product information

Catalog Number :

MAB2237

Subcategory :

Neuroscience

Product Name :

Anti-Syntrophin Antibody, clone 1351

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q13884

Host Name :

Mouse

Antigen :

Syntrophin

Clone :

1351

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Syntrophin Antibody, clone 1351

Cross Reactivity :

Rabbit;Mouse;Rat;Human;Shark

Background :

The syntrophins are a family of scaffolding proteins with multiple protein interaction domains that link signaling proteins to dystrophin family members. Each of the three most characterized syntrophins (α, β1, β2) contains a PDZ domain that binds a unique set of signaling proteins including kinases, ion and water channels, and neuronal nitric oxide synthase (nNOS). Despite their ability to bind dystrophin in vitro, neither γ-syntrophin isoform co-localizes with dystrophin in skeletal muscle. Furthermore, γ-syntrophins do not co-purify with dystrophin isolated from mouse tissue. Research suggests that the interaction of γ-syntrophin with dystrophin is transient and potentially subject to regulatory mechanisms. γ1-Syntrophin is highly expressed in brain and is specifically localized in hippocampal pyramidal neurons, Purkinje neurons in cerebellum, and cortical neurons. γ2-Syntrophin is expressed in many tissues including skeletal muscle where it is found only in the subsynaptic space beneath the neuromuscular junction. In both neurons and muscle, γ-syntrophin isoforms localize to the endoplasmic reticulum where they may form a scaffold for signaling and trafficking (Adams, 2006).

ALT Names :

59 kDa dystrophin-associated protein A1 basic component 1 ;Tax interaction protein 43;basic beta 1 syntrophin;dystrophin-associated protein A1, 59kD, basic component 1;syntrophin, beta 1 (dystrophin-associated protein A1, 59kD, basic component 1);syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)

Immunogen :

Whole purified syntrophin from Torpedo californica electric organ postsynaptic membrane.

Specificity :

Cat. # MAB2237 recognizes Syntrophin.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8ºC from date of receipt.