Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8 | EMD Millipore MAB2168 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8

catalog :

MAB2168

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HU-2E8

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 8

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; fig s1	Southwell A, Smith S, Davis T, Caron N, Villanueva E, Xie Y, et al. Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression. Sci Rep. 2015;5:12166 pubmed publisher
	Masnata M, Sciacca G, Maxan A, Bousset L, Denis H, Lauruol F, et al. Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms. Acta Neuropathol. 2019;137:981-1001 pubmed publisher
	Sapp E, Valencia A, Li X, Aronin N, Kegel K, Vonsattel J, et al. Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer. J Biol Chem. 2012;287:13487-99 pubmed publisher
	Maglione V, Marchi P, Di Pardo A, Lingrell S, Horkey M, Tidmarsh E, et al. Impaired ganglioside metabolism in Huntington's disease and neuroprotective role of GM1. J Neurosci. 2010;30:4072-80 pubmed publisher
	Tang T, Guo C, Wang H, Chen X, Bezprozvanny I. Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model. J Neurosci. 2009;29:1257-66 pubmed publisher
	Desplats P, Lambert J, Thomas E. Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease. Neurobiol Dis. 2008;31:298-308 pubmed publisher
	Ciammola A, Sassone J, Alberti L, Meola G, Mancinelli E, Russo M, et al. Increased apoptosis, Huntingtin inclusions and altered differentiation in muscle cell cultures from Huntington's disease subjects. Cell Death Differ. 2006;13:2068-78 pubmed
	Takano H, Gusella J. The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor. BMC Neurosci. 2002;3:15 pubmed

product information

Catalog Number :

MAB2168

Subcategory :

Neuroscience

Product Name :

Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P42858

Host Name :

Mouse

Antigen :

Huntingtin Protein

Clone :

HU-2E8

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8

Cross Reactivity :

Human;Monkey

Immunogen :

Human huntingtin fragment from aa 2146 to 2541 as a fusion protein.

Specificity :

Reacts with Huntingtin protein from human and monkey. Weak to no reactivity with mouse. Has not been tested on other species.

Package Size :

100 µL

Uses :

ELISA;Western Blotting;Immunocytochemistry;Immunohistochemistry (Paraffin)

Storage :

Maintain at -20°C in undiluted aliquots up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For antibodies with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.