Fragile X Mental Retardation Protein Antibody, clone 1C3 | EMD Millipore MAB2160 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Fragile X Mental Retardation Protein Antibody, clone 1C3

catalog :

MAB2160

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1C3

The same clone is also sold as:

LifeSpan Biosciences: LS-C15265

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry knockout validation

citations: 33

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry knockout validation; mouse; 1:500; loading ...; fig 1d	Shen M, Wang F, Li M, Sah N, Stockton M, Tidei J, et al. Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice. Nat Neurosci. 2019;22:386-400 pubmed publisher
western blot; human; loading ...; fig 6	Barrows N, Anglero Rodriguez Y, Kim B, Jamison S, Le Sommer C, McGee C, et al. Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis. Sci Rep. 2019;9:9711 pubmed publisher
immunocytochemistry; mouse; 1:500; fig 2b	Culver B, DeClercq J, Dolgalev I, Yu M, Ma B, Heguy A, et al. Huntington's Disease Protein Huntingtin Associates with its own mRNA. J Huntingtons Dis. 2016;5:39-51 pubmed publisher
immunohistochemistry; rat; 1:1500; loading ...; fig 1a	Till S, Asiminas A, Jackson A, Katsanevaki D, Barnes S, Osterweil E, et al. Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS. Hum Mol Genet. 2015;24:5977-84 pubmed publisher
western blot; human; 1:500; fig 1	Okray Z, de Esch C, Van Esch H, Devriendt K, Claeys A, Yan J, et al. A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function. EMBO Mol Med. 2015;7:423-37 pubmed publisher
western blot; mouse; 1:1000	Renoux A, Carducci N, Ahmady A, Todd P. Fragile X mental retardation protein expression in Alzheimer's disease. Front Genet. 2014;5:360 pubmed publisher
western blot; mouse	Guo H, Chitiprolu M, Gagnon D, Meng L, Perez Iratxeta C, Lagace D, et al. Autophagy supports genomic stability by degrading retrotransposon RNA. Nat Commun. 2014;5:5276 pubmed publisher
western blot; human; 1:5000	Kumari D, Bhattacharya A, Nadel J, Moulton K, Zeak N, Glicksman A, et al. Identification of fragile X syndrome specific molecular markers in human fibroblasts: a useful model to test the efficacy of therapeutic drugs. Hum Mutat. 2014;35:1485-94 pubmed publisher
western blot; human; 1:500	Fatemi S, Folsom T, Rooney R, Thuras P. mRNA and protein expression for novel GABAA receptors ? and ?2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway. Transl Psychiatry. 2013;3:e271 pubmed publisher
immunohistochemistry; human; 1:200	Pretto D, Hunsaker M, Cunningham C, Greco C, Hagerman R, Noctor S, et al. Intranuclear inclusions in a fragile X mosaic male. Transl Neurodegener. 2013;2:10 pubmed publisher
western blot; human	LaFauci G, Adayev T, Kascsak R, Kascsak R, Nolin S, Mehta P, et al. Fragile X screening by quantification of FMRP in dried blood spots by a Luminex immunoassay. J Mol Diagn. 2013;15:508-17 pubmed publisher
	Haghandish N, Baldwin R, Morettin A, Dawit H, Adhikary H, Masson J, et al. PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation. Mol Biol Cell. 2019;30:778-793 pubmed publisher
	Hirano M, Muto M, Sakai M, Kondo H, Kobayashi S, Kariwa H, et al. Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A. 2017;114:9960-9965 pubmed publisher
	Rollins M, Huard S, Morettin A, Takuski J, Pham T, Fullerton M, et al. Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae. PLoS Genet. 2017;13:e1006626 pubmed publisher
	Ahmad M, Xue Y, Lee S, Martindale J, Shen W, Li W, et al. RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals. Nucleic Acids Res. 2016;44:6335-49 pubmed publisher
	Spencer K, Mulholland P, Chandler L. FMRP Mediates Chronic Ethanol-Induced Changes in NMDA, Kv4.2, and KChIP3 Expression in the Hippocampus. Alcohol Clin Exp Res. 2016;40:1251-61 pubmed publisher
	Stepniak B, KÃ¤stner A, Poggi G, Mitjans M, Begemann M, Hartmann A, et al. Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes. EMBO Mol Med. 2015;7:1565-79 pubmed publisher
	Bartley C, O Keefe R, Bordey A. FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity. PLoS ONE. 2014;9:e96956 pubmed publisher
	Ferron L, Nieto Rostro M, Cassidy J, Dolphin A. Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density. Nat Commun. 2014;5:3628 pubmed publisher
	Xu D, Shen W, Guo R, Xue Y, Peng W, Sima J, et al. Top3Î² is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation. Nat Neurosci. 2013;16:1238-47 pubmed publisher
	Schutzius G, Bleckmann D, Kapps Fouthier S, di Giorgio F, Gerhartz B, Weiss A. A quantitative homogeneous assay for fragile X mental retardation 1 protein. J Neurodev Disord. 2013;5:8 pubmed publisher
	Jeon S, Han S, Yang S, Choi J, Kwon K, Park S, et al. Positive feedback regulation of Akt-FMRP pathway protects neurons from cell death. J Neurochem. 2012;123:226-38 pubmed publisher
	SHERIDAN S, Theriault K, Reis S, Zhou F, Madison J, Daheron L, et al. Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome. PLoS ONE. 2011;6:e26203 pubmed publisher
	Iioka H, Loiselle D, Haystead T, Macara I. Efficient detection of RNA-protein interactions using tethered RNAs. Nucleic Acids Res. 2011;39:e53 pubmed publisher
	Zang J, Nosyreva E, Spencer C, Volk L, Musunuru K, Zhong R, et al. A mouse model of the human Fragile X syndrome I304N mutation. PLoS Genet. 2009;5:e1000758 pubmed publisher
	Eiges R, Urbach A, Malcov M, Frumkin T, Schwartz T, Amit A, et al. Developmental study of fragile X syndrome using human embryonic stem cells derived from preimplantation genetically diagnosed embryos. Cell Stem Cell. 2007;1:568-77 pubmed publisher
	Biacsi R, Kumari D, Usdin K. SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome. PLoS Genet. 2008;4:e1000017 pubmed publisher
	Gottfried Blackmore A, Croft G, Clark J, McEwen B, Jellinck P, Bulloch K. Characterization of a cerebellar granule progenitor cell line, EtC.1, and its responsiveness to 17-beta-estradiol. Brain Res. 2007;1186:29-40 pubmed
	Zalfa F, Eleuteri B, Dickson K, Mercaldo V, De Rubeis S, Di Penta A, et al. A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability. Nat Neurosci. 2007;10:578-87 pubmed
	Wang H, Iacoangeli A, Lin D, Williams K, Denman R, Hellen C, et al. Dendritic BC1 RNA in translational control mechanisms. J Cell Biol. 2005;171:811-21 pubmed
	Gagné J, Bonicalzi M, Gagne P, Ouellet M, Hendzel M, Poirier G. Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles. Biochem J. 2005;392:499-509 pubmed
	Darnell J, Mostovetsky O, Darnell R. FMRP RNA targets: identification and validation. Genes Brain Behav. 2005;4:341-9 pubmed
	Huot M, Bisson N, Davidovic L, Mazroui R, Labelle Y, Moss T, et al. The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis. Mol Biol Cell. 2005;16:4350-61 pubmed

product information

Catalog Number :

MAB2160

Subcategory :

Neuroscience

Product Name :

Anti-Fragile X Mental Retardation Protein Antibody, clone 1C3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q06787

Host Name :

Mouse

Antigen :

Fragile X Mental Retardation Protein

Clone :

1C3

Conjugate :

Ascites

Isotype :

IgG1κ

Product Description :

Anti-Fragile X Mental Retardation Protein Antibody, clone 1C3

Cross Reactivity :

Human;Mouse;Rat

Background :

Fragile X Mental Retardation Protein (FMRP) is a RNA-binding protein that is associated to polysomes and may be involved in the transport of mRNA from the nucleus to the cytoplasm. Defects in FMR1 are the cause of Fragile X syndrome, which is a common genetic disease characterized by moderate to severe mental retardation, macroorchidism, large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.

ALT Names :

FMRP

Immunogen :

Fusion protein with a full length FMRP (human).

Specificity :

Human and mouse FMRP. The epitope is localized in the N-terminal half of FMRP. Cross reaction with FXR protein may be detected in cases of high expression of the latter proteins.

Package Size :

100 µL

Uses :

ELISA;Immunocytochemistry;Immunohistochemistry;Immunohistochemistry (Paraffin);Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.