Endoglin Antibody, clone P3D1, Alexa Fluor® 488 conjugated | EMD Millipore MAB2152X product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Endoglin Antibody, clone P3D1, Alexa Fluor® 488 conjugated

catalog :

MAB2152X

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

P3D1

The same clone is also sold as:

Santa Cruz Biotechnology: sc-18838
Developmental Studies Hybridoma Bank: P3D1

reactivity :

human

application :

immunocytochemistry, flow cytometry

citations: 4

Reference
Valenzuela N, Mulder A, Reed E. HLA class I antibodies trigger increased adherence of monocytes to endothelial cells by eliciting an increase in endothelial P-selectin and, depending on subclass, by engaging Fc?Rs. J Immunol. 2013;190:6635-50 pubmed publisher
Walsh E, Kim R, Del Valle L, Weaver M, Sheffield J, Lazarovici P, et al. Importance of interaction between nerve growth factor and ?9?1 integrin in glial tumor angiogenesis. Neuro Oncol. 2012;14:890-901 pubmed publisher
Ji H, Zhao G, Luo J, Zhao X, Zhang M. Taurine postponed the replicative senescence of rat bone marrow-derived multipotent stromal cells in vitro. Mol Cell Biochem. 2012;366:259-67 pubmed publisher
Nandoe Tewarie R, Bossers K, Ritfeld G, Blits B, Grotenhuis J, Verhaagen J, et al. Early passage bone marrow stromal cells express genes involved in nervous system development supporting their relevance for neural repair. Restor Neurol Neurosci. 2011;29:187-201 pubmed publisher

product information

Catalog Number :

MAB2152X

Subcategory :

Cell Structure

Product Name :

Anti-Endoglin Antibody, clone P3D1, Alexa Fluor® 488 conjugated

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P17813

Host Name :

Mouse

Antigen :

Endoglin

Clone :

P3D1

Conjugate :

AlexaFluor®488

Isotype :

IgG2a

Product Description :

Anti-Endoglin Antibody, clone P3D1, Alexa Fluor® 488 conjugated

Cross Reactivity :

Human

Background :

Human endoglin (ancillaryTGF-beta receptor). Endoglin is a transmembrane glycoprotein expressed by vascular endothelial cells. It functions as an ancillary receptor influencing binding of the Transforming Growth Factor beta (TGF-beta) family ligands to signalling receptors. homodimeric integral membrane protein comprised of 95Kd subunits (CD105). CD105 is a component of the TGF-B receptor system and can bind TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. CD105 is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. U937 cells and activated macrophages also expresses CD105. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, ,such as in tumors, or in cases of wound healing or dermal inflammation. The epitope of clone P3D1 as well as the epitopes of several other endoglin clones is mapped in the this reference: Puchuantes, S et al (1997) Tissue Antigens 50(3):265-76.

Immunogen :

Human resting umbilical vein endothelial cells

Specificity :

Reacts with human endoglin.

Package Size :

100 µg

Uses :

Flow Cytometry;Immunocytochemistry

Storage :

Maintain at 2°-8°C for up to 12 months from date of receipt.