This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Integrin α2β1 Antibody, clone BHA2.1
catalog :
MAB1998
quantity :
100 μg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
BHA2.1
reactivity :
human
application :
immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, blocking or activating experiments
citations: 32
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human
Feng X, Tonnesen M, Mousa S, Clark R. Fibrin and collagen differentially but synergistically regulate sprout angiogenesis of human dermal microvascular endothelial cells in 3-dimensional matrix. Int J Cell Biol. 2013;2013:231279 pubmed publisher
Ikeuchi T, de Vega S, Forcinito P, Doyle A, Amaral J, Rodriguez I, et al. Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In Vivo Antiangiogenic Activity. Sci Rep. 2018;8:17654 pubmed publisher
Naci D, Aoudjit F. Alpha2beta1 integrin promotes T cell survival and migration through the concomitant activation of ERK/Mcl-1 and p38 MAPK pathways. Cell Signal. 2014;26:2008-15 pubmed publisher
Lee S, Cheng H, Yuan Y, Wu S. Regulation of ionizing radiation-induced adhesion of breast cancer cells to fibronectin by alpha5beta1 integrin. Radiat Res. 2014;181:650-8 pubmed publisher
Li X, Ishihara S, Yasuda M, Nishioka T, Mizutani T, Ishikawa M, et al. Lung cancer cells that survive ionizing radiation show increased integrin α2β1- and EGFR-dependent invasiveness. PLoS ONE. 2013;8:e70905 pubmed publisher
Tang S, Lucius R, Wenck H, Gallinat S, Weise J. UV-mediated downregulation of the endocytic collagen receptor, Endo180, contributes to accumulation of extracellular collagen fragments in photoaged skin. J Dermatol Sci. 2013;70:42-8 pubmed publisher
Kemeny S, Cicalese S, Figueroa D, Clyne A. Glycated collagen and altered glucose increase endothelial cell adhesion strength. J Cell Physiol. 2013;228:1727-36 pubmed publisher
Hozumi K, Ishikawa M, Hayashi T, Yamada Y, Katagiri F, Kikkawa Y, et al. Identification of cell adhesive sequences in the N-terminal region of the laminin ?2 chain. J Biol Chem. 2012;287:25111-22 pubmed publisher
Tabariès S, Dupuy F, Dong Z, Monast A, Annis M, Spicer J, et al. Claudin-2 promotes breast cancer liver metastasis by facilitating tumor cell interactions with hepatocytes. Mol Cell Biol. 2012;32:2979-91 pubmed publisher
Xia H, Seeman J, Hong J, Hergert P, Bodem V, Jessurun J, et al. Low ?(2)?(1) integrin function enhances the proliferation of fibroblasts from patients with idiopathic pulmonary fibrosis by activation of the ?-catenin pathway. Am J Pathol. 2012;181:222-33 pubmed publisher
Labonté L, Li Y, Addison C, Brand M, Javidnia H, Corsten M, et al. Distinct profile of vascular progenitor attachment to extracellular matrix proteins in cancer patients. Clin Invest Med. 2012;35:E86-95 pubmed
Arjonen A, Alanko J, Veltel S, Ivaska J. Distinct recycling of active and inactive ?1 integrins. Traffic. 2012;13:610-25 pubmed publisher
Dzobo K, Leaner V, Parker M. Feedback regulation of the ?2(1) collagen gene via the Mek-Erk signaling pathway. IUBMB Life. 2012;64:87-98 pubmed publisher
Goswami R, Bajjuri K, Forsyth J, Das S, Hassenpflug W, Huang Z, et al. Chemically programmed antibodies targeting multiple alpha(v) integrins and their effects on tumor-related functions in vitro. Bioconjug Chem. 2011;22:1535-44 pubmed publisher
Lord M, Cheng B, McCarthy S, Jung M, Whitelock J. The modulation of platelet adhesion and activation by chitosan through plasma and extracellular matrix proteins. Biomaterials. 2011;32:6655-62 pubmed publisher
Yamada Y, Katagiri F, Hozumi K, Kikkawa Y, Nomizu M. Cell behavior on protein matrices containing laminin ?1 peptide AG73. Biomaterials. 2011;32:4327-35 pubmed publisher
Wu C, Li T, Hsu S, Su Y, Kao S, Fong Y, et al. IGF-I enhances ?5?1 integrin expression and cell motility in human chondrosarcoma cells. J Cell Physiol. 2011;226:3270-7 pubmed publisher
Rybak A, He L, Kapoor A, Cutz J, Tang D. Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells. Biochim Biophys Acta. 2011;1813:683-94 pubmed publisher
Lu S, Li F, Yin H, Feng Q, Kimbrel E, Hahm E, et al. Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice. Cell Res. 2011;21:530-45 pubmed publisher
Chen S, Tsai Y, Wu C, Liao S, Wu L, Chang C, et al. Streptococcal collagen-like surface protein 1 promotes adhesion to the respiratory epithelial cell. BMC Microbiol. 2010;10:320 pubmed publisher
Wright S, Parham C, Lee B, Clarke D, Auckland L, Johnston J, et al. Perlecan domain V inhibits ?2 integrin-mediated amyloid-? neurotoxicity. Neurobiol Aging. 2012;33:1379-88 pubmed publisher
de Neergaard M, Kim J, Villadsen R, Fridriksdottir A, Rank F, Timmermans Wielenga V, et al. Epithelial-stromal interaction 1 (EPSTI1) substitutes for peritumoral fibroblasts in the tumor microenvironment. Am J Pathol. 2010;176:1229-40 pubmed publisher
Ko S, Lengyel E, Naora H. The Müllerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial-stromal interactions. Mol Cell Endocrinol. 2010;317:112-9 pubmed publisher
Riva F, Casasco A, Casasco M, Calligaro A, Cornaglia A. Growth and stratification of epithelial cells in minimal culture conditions. Methods Mol Biol. 2010;585:25-43 pubmed publisher
Gaide Chevronnay H, Galant C, Lemoine P, Courtoy P, Marbaix E, Henriet P. Spatiotemporal coupling of focal extracellular matrix degradation and reconstruction in the menstrual human endometrium. Endocrinology. 2009;150:5094-105 pubmed publisher
Kawajiri H, Yashiro M, Shinto O, Nakamura K, Tendo M, Takemura S, et al. A novel transforming growth factor beta receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma. Clin Cancer Res. 2008;14:2850-60 pubmed publisher
Pula G, Poole A. Critical roles for the actin cytoskeleton and cdc42 in regulating platelet integrin alpha2beta1. Platelets. 2008;19:199-210 pubmed publisher
Xu L, Peng H, Glasson S, Lee P, Hu K, Ijiri K, et al. Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis. Arthritis Rheum. 2007;56:2663-73 pubmed
Saunders W, Bohnsack B, Faske J, Anthis N, Bayless K, Hirschi K, et al. Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3. J Cell Biol. 2006;175:179-91 pubmed
Znoyko I, Trojanowska M, Reuben A. Collagen binding alpha2beta1 and alpha1beta1 integrins play contrasting roles in regulation of Ets-1 expression in human liver myofibroblasts. Mol Cell Biochem. 2006;282:89-99 pubmed
Riemenschneider M, Mueller W, Betensky R, Mohapatra G, Louis D. In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation. Am J Pathol. 2005;167:1379-87 pubmed
Nesbitt W, Giuliano S, Kulkarni S, Dopheide S, Harper I, Jackson S. Intercellular calcium communication regulates platelet aggregation and thrombus growth. J Cell Biol. 2003;160:1151-61 pubmed
product information
Catalog Number :
MAB1998
Subcategory :
Cell Structure
Product Name :
Anti-Integrin α2β1 Antibody, clone BHA2.1
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P17301
Host Name :
Mouse
Antigen :
Integrin α2β1
Clone :
BHA2.1
Conjugate :
Purified
Isotype :
IgG1κ
Product Description :
Anti-Integrin α2β1 Antibody, clone BHA2.1
Cross Reactivity :
Canine;Human;Pig
ALT Names :
VLA-2
Specificity :
Reacts with the collagen receptor VLA-2 (alpha-2beta-1) integrin complex.
Package Size :
100 μg
Uses :
Flow Cytometry;Immunohistochemistry;Immunohistochemistry (Paraffin);Immunoprecipitation;Affects Function
Storage :
Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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