This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Integrin β1 Antibody, clone P4C10
catalog :
MAB1987
quantity :
100 µL
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
P4C10

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, blocking or activating experiments
citations: 57
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; fig 3b
  • western blot; human; fig 3c
Suginami K, Sato Y, Horie A, Matsumoto H, Kyo S, Araki Y, et al. Platelets are a possible regulator of human endometrial re-epithelialization during menstruation. Am J Reprod Immunol. 2017;77: pubmed publisher
  • blocking or activating experiments; human; loading ...; fig s1c
Kolanowski S, van Schijndel G, Van Ham S, ten Brinke A. Adaptation to replating of dendritic cells synergizes with Toll-like receptor stimuli and enhances the pro-inflammatory cytokine profile. Cytotherapy. 2016;18:902-10 pubmed publisher
  • blocking or activating experiments; human; 1:200
Fu X, Xu M, Liu J, Qi Y, Li S, Wang H. Regulation of migratory activity of human keratinocytes by topography of multiscale collagen-containing nanofibrous matrices. Biomaterials. 2014;35:1496-506 pubmed publisher
  • immunocytochemistry; human; 10 ug/ml
Queisser M, Kouri F, Konigshoff M, Wygrecka M, Schubert U, Eickelberg O, et al. Loss of RAGE in pulmonary fibrosis: molecular relations to functional changes in pulmonary cell types. Am J Respir Cell Mol Biol. 2008;39:337-45 pubmed publisher
Guo L, Wang R, Zhang K, Yuan J, Wang J, Wang X, et al. A PINCH-1-Smurf1 signaling axis mediates mechano-regulation of BMPR2 and stem cell differentiation. J Cell Biol. 2019;218:3773-3794 pubmed publisher
Guo L, Cui C, Zhang K, Wang J, Wang Y, Lu Y, et al. Kindlin-2 links mechano-environment to proline synthesis and tumor growth. Nat Commun. 2019;10:845 pubmed publisher
Meshik X, O Neill P, Gautam N. Physical Plasma Membrane Perturbation Using Subcellular Optogenetics Drives Integrin-Activated Cell Migration. ACS Synth Biol. 2019;8:498-510 pubmed publisher
Urner S, Planas Paz L, Hilger L, Henning C, Branopolski A, Kelly Goss M, et al. Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth. EMBO J. 2019;38: pubmed publisher
Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, et al. Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin. Nat Commun. 2018;9:3524 pubmed publisher
Guo L, Cai T, Chen K, Wang R, Wang J, Cui C, et al. Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZ. J Cell Biol. 2018;217:1431-1451 pubmed publisher
Chang K, Zollinger D, Susuki K, Sherman D, Makara M, Brophy P, et al. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat Neurosci. 2014;17:1673-81 pubmed publisher
Liu C, Hu R, Huang M, Lai I, Chen C, Lai H, et al. C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin ?1 glycosylation and activity. PLoS ONE. 2014;9:e94995 pubmed publisher
von Kietzell K, Pozzuto T, Heilbronn R, Grössl T, Fechner H, Weger S. Antibody-mediated enhancement of parvovirus B19 uptake into endothelial cells mediated by a receptor for complement factor C1q. J Virol. 2014;88:8102-15 pubmed publisher
Cheng N, van Zandwijk N, Reid G. Cilengitide inhibits attachment and invasion of malignant pleural mesothelioma cells through antagonism of integrins ?v?3 and ?v?5. PLoS ONE. 2014;9:e90374 pubmed publisher
Chen C, Wang S, Liu C, Wu Y, Wang W, Huang J, et al. ?-1,4-Galactosyltransferase III suppresses ?1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer. Carcinogenesis. 2014;35:1258-66 pubmed publisher
Rizqiawan A, Tobiume K, Okui G, Yamamoto K, Shigeishi H, Ono S, et al. Autocrine galectin-1 promotes collective cell migration of squamous cell carcinoma cells through up-regulation of distinct integrins. Biochem Biophys Res Commun. 2013;441:904-10 pubmed publisher
Trad A, Riese M, Shomali M, Hedeman N, Effenberger T, Grötzinger J, et al. The disintegrin domain of ADAM17 antagonises fibroblast?carcinoma cell interactions. Int J Oncol. 2013;42:1793-800 pubmed publisher
Jerke U, Rolle S, Purfürst B, Luft F, Nauseef W, Kettritz R. ?2 integrin-mediated cell-cell contact transfers active myeloperoxidase from neutrophils to endothelial cells. J Biol Chem. 2013;288:12910-9 pubmed publisher
Chang H, Chen C, Chou C, Liao Y, Huang M, Chen Y, et al. ?-1,4-Galactosyltransferase III enhances invasive phenotypes via ?1-integrin and predicts poor prognosis in neuroblastoma. Clin Cancer Res. 2013;19:1705-16 pubmed publisher
Wong W, Sigvardsson M, Astrand Grundström I, Hogge D, Larsson J, Qian H, et al. Expression of integrin ?2 receptor in human cord blood CD34+CD38-CD90+ stem cells engrafting long-term in NOD/SCID-IL2R?(c) null mice. Stem Cells. 2013;31:360-71 pubmed publisher
Liao W, Liu C, Huang M, Chen C, Hung J, Chou C, et al. Expression of GALNT2 in human extravillous trophoblasts and its suppressive role in trophoblast invasion. Placenta. 2012;33:1005-11 pubmed publisher
Teo G, Ankrum J, Martinelli R, Boetto S, Simms K, Sciuto T, et al. Mesenchymal stem cells transmigrate between and directly through tumor necrosis factor-?-activated endothelial cells via both leukocyte-like and novel mechanisms. Stem Cells. 2012;30:2472-86 pubmed publisher
Madera L, Hancock R. Synthetic immunomodulatory peptide IDR-1002 enhances monocyte migration and adhesion on fibronectin. J Innate Immun. 2012;4:553-68 pubmed publisher
Balzer E, Tong Z, Paul C, Hung W, Stroka K, Boggs A, et al. Physical confinement alters tumor cell adhesion and migration phenotypes. FASEB J. 2012;26:4045-56 pubmed publisher
Andrian E, Qi G, Wang J, Halperin S, Lee S. Role of surface proteins SspA and SspB of Streptococcus gordonii in innate immunity. Microbiology. 2012;158:2099-106 pubmed publisher
Mortillo S, Elste A, Ge Y, Patil S, Hsiao K, Huntley G, et al. Compensatory redistribution of neuroligins and N-cadherin following deletion of synaptic ?1-integrin. J Comp Neurol. 2012;520:2041-52 pubmed publisher
Beauséjour M, Noël D, Thibodeau S, Bouchard V, Harnois C, Beaulieu J, et al. Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes. Apoptosis. 2012;17:566-78 pubmed publisher
Shields M, Krantz S, Bentrem D, Dangi Garimella S, Munshi H. Interplay between ?1-integrin and Rho signaling regulates differential scattering and motility of pancreatic cancer cells by snail and Slug proteins. J Biol Chem. 2012;287:6218-29 pubmed publisher
Lee C, Marzan D, Lin G, Goodison S, Silletti S. ?2 Integrin-Dependent Suppression of Pancreatic Adenocarcinoma Cell Invasion Involves Ectodomain Regulation of Kallikrein-Related Peptidase-5. J Oncol. 2011;2011:365651 pubmed publisher
Huang C, Fu X, Liu J, Qi Y, Li S, Wang H. The involvement of integrin ?1 signaling in the migration and myofibroblastic differentiation of skin fibroblasts on anisotropic collagen-containing nanofibers. Biomaterials. 2012;33:1791-800 pubmed publisher
Khaled S, Gupta K, Kucik D. Ionizing radiation increases adhesiveness of human aortic endothelial cells via a chemokine-dependent mechanism. Radiat Res. 2012;177:594-601 pubmed
Case L, Waterman C. Adhesive F-actin waves: a novel integrin-mediated adhesion complex coupled to ventral actin polymerization. PLoS ONE. 2011;6:e26631 pubmed publisher
Shyu M, Chen C, Lin N, Liao W, Chen C, Lin C, et al. MUC1 expression is elevated in severe preeclamptic placentas and suppresses trophoblast cell invasion via ?1-integrin signaling. J Clin Endocrinol Metab. 2011;96:3759-67 pubmed publisher
Guilluy C, Swaminathan V, Garcia Mata R, O Brien E, Superfine R, Burridge K. The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins. Nat Cell Biol. 2011;13:722-7 pubmed publisher
Zhang Y, Chen M, Venugopal S, Zhou Y, Xiang W, Li Y, et al. Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state. Cell Death Dis. 2011;2:e153 pubmed publisher
Vartanian A, Stepanova E, Grigorieva I, Solomko E, Belkin V, Baryshnikov A, et al. Melanoma vasculogenic mimicry capillary-like structure formation depends on integrin and calcium signaling. Microcirculation. 2011;18:390-9 pubmed publisher
Baker A, Cox T, Bird D, Lang G, Murray G, Sun X, et al. The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer. J Natl Cancer Inst. 2011;103:407-24 pubmed publisher
Nagaharu K, Zhang X, Yoshida T, Katoh D, Hanamura N, Kozuka Y, et al. Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells. Am J Pathol. 2011;178:754-63 pubmed publisher
Collie A, Bota P, Johns R, Maier R, Stayton P. Differential monocyte/macrophage interleukin-1? production due to biomaterial topography requires the ?2 integrin signaling pathway. J Biomed Mater Res A. 2011;96:162-9 pubmed publisher
Alexopoulou A, Leao M, Caballero O, Da Silva L, Reid L, Lakhani S, et al. Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines. Breast Cancer Res. 2010;12:R51 pubmed publisher
Auriemma C, Viscardi M, Tafuri S, Pavone L, Capuano F, Rinaldi L, et al. Integrin receptors play a role in the internalin B-dependent entry of Listeria monocytogenes into host cells. Cell Mol Biol Lett. 2010;15:496-506 pubmed publisher
Sato K, Ozawa S, Izukuri K, Kato Y, Hata R. Expression of tumour-suppressing chemokine BRAK/CXCL14 reduces cell migration rate of HSC-3 tongue carcinoma cells and stimulates attachment to collagen and formation of elongated focal adhesions in vitro. Cell Biol Int. 2010;34:513-22 pubmed publisher
Maijenburg M, Noort W, Kleijer M, Kompier C, Weijer K, van Buul J, et al. Cell cycle and tissue of origin contribute to the migratory behaviour of human fetal and adult mesenchymal stromal cells. Br J Haematol. 2010;148:428-40 pubmed publisher
Elphick G, Sarangi P, Hyun Y, Hollenbaugh J, Ayala A, Biffl W, et al. Recombinant human activated protein C inhibits integrin-mediated neutrophil migration. Blood. 2009;113:4078-85 pubmed publisher
van Gils J, Stutterheim J, van Duijn T, Zwaginga J, Porcelijn L, de Haas M, et al. HPA-1a alloantibodies reduce endothelial cell spreading and monolayer integrity. Mol Immunol. 2009;46:406-15 pubmed publisher
Schmid M, Varner J. Chapter 15. Methods to study myeloid cell roles in angiogenesis. Methods Enzymol. 2008;445:343-71 pubmed publisher
Mosig S, Rennert K, Krause S, Kzhyshkowska J, Neunübel K, Heller R, et al. Different functions of monocyte subsets in familial hypercholesterolemia: potential function of CD14+ CD16+ monocytes in detoxification of oxidized LDL. FASEB J. 2009;23:866-74 pubmed publisher
Tzoneva R, Faucheux N, Groth T. Wettability of substrata controls cell-substrate and cell-cell adhesions. Biochim Biophys Acta. 2007;1770:1538-47 pubmed
Wang J, Gualco E, Peruzzi F, Sawaya B, Passiatore G, Marcinkiewicz C, et al. Interaction between serine phosphorylated IRS-1 and beta1-integrin affects the stability of neuronal processes. J Neurosci Res. 2007;85:2360-73 pubmed
Fouchier F, Penel C, Pierre Montero M, Bremond P, Champion S. Integrin alphavbeta6 mediates HT29-D4 cell adhesion to MMP-processed fibrinogen in the presence of Mn2+. Eur J Cell Biol. 2007;86:143-60 pubmed
Kuo J, Wang W, Yao C, Wu P, Chen R. The tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway. J Cell Biol. 2006;172:619-31 pubmed
Goel H, Moro L, King M, Teider N, Centrella M, McCarthy T, et al. Beta1 integrins modulate cell adhesion by regulating insulin-like growth factor-II levels in the microenvironment. Cancer Res. 2006;66:331-42 pubmed
Wang J, Grabacka M, Marcinkiewicz C, Staniszewska I, Peruzzi F, Khalili K, et al. Involvement of alpha1beta1 integrin in insulin-like growth factor-1-mediated protection of PC12 neuronal processes from tumor necrosis factor-alpha-induced injury. J Neurosci Res. 2006;83:7-18 pubmed
Short S, Derrien A, Narsimhan R, Lawler J, Ingber D, Zetter B. Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins. J Cell Biol. 2005;168:643-53 pubmed
Goel H, Fornaro M, Moro L, Teider N, Rhim J, King M, et al. Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins. J Cell Biol. 2004;166:407-18 pubmed
Hintermann E, Bilban M, Sharabi A, Quaranta V. Inhibitory role of alpha 6 beta 4-associated erbB-2 and phosphoinositide 3-kinase in keratinocyte haptotactic migration dependent on alpha 3 beta 1 integrin. J Cell Biol. 2001;153:465-78 pubmed
Silletti S, Mei F, Sheppard D, Montgomery A. Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitment. J Cell Biol. 2000;149:1485-502 pubmed
product information
Catalog Number :
MAB1987
Subcategory :
Cell Structure
Product Name :
Anti-Integrin β1 Antibody, clone P4C10
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P05556
Host Name :
Mouse
Antigen :
Integrin β1
Clone :
P4C10
Conjugate :
Culture Supernatant
Isotype :
IgG2a
Product Description :
Anti-Integrin β1 Antibody, clone P4C10
Cross Reactivity :
Human
ALT Names :
CD29
Specificity :
Reacts with the beta-1 subunit of the integrin protein family. Appears to be human specific. Unlike many beta-1 monoclonals 4C10's epitope is not trypsin sensitive.
Package Size :
100 µL
Uses :
ELISA;Immunoprecipitation;Western Blotting;Immunocytochemistry;Affects Function
Storage :
Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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