This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Integrin αVβ3 Antibody, clone LM609, Azide Free
catalog :
MAB1976Z
quantity :
100 μg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
LM609

The same clone is also sold as:
reactivity :
Common quail, human, mouse, bovine
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section, proximity ligation assay, blocking or activating experiments
citations: 189
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; 2.5 ug/ml; fig 3b
Wang S, Zhang Q, Tiwari S, Lichinchi G, Yau E, Hui H, et al. Integrin αvβ5 Internalizes Zika Virus during Neural Stem Cells Infection and Provides a Promising Target for Antiviral Therapy. Cell Rep. 2020;30:969-983.e4 pubmed publisher
  • western blot; human; fig 6a
Yoo S, Leng L, Kim B, Du X, Tilstam P, Kim K, et al. MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2016;113:E7917-E7926 pubmed
  • flow cytometry; bovine
Guzman E, Taylor G, Hope J, Herbert R, Cubillos Zapata C, Charleston B. Transduction of skin-migrating dendritic cells by human adenovirus 5 occurs via an actin-dependent phagocytic pathway. J Gen Virol. 2016;97:2703-2718 pubmed publisher
  • blocking or activating experiments; human; fig 2
Cornick S, Moreau F, Chadee K. Entamoeba histolytica Cysteine Proteinase 5 Evokes Mucin Exocytosis from Colonic Goblet Cells via αvβ3 Integrin. PLoS Pathog. 2016;12:e1005579 pubmed publisher
  • proximity ligation assay; human; 1:1000; fig s3
Fiore V, Strane P, Bryksin A, White E, Hagood J, Barker T. Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction. J Cell Biol. 2015;211:173-90 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 6
Zoppi N, Chiarelli N, Cinquina V, Ritelli M, Colombi M. GLUT10 deficiency leads to oxidative stress and non-canonical αvβ3 integrin-mediated TGFβ signalling associated with extracellular matrix disarray in arterial tortuosity syndrome skin fibroblasts. Hum Mol Genet. 2015;24:6769-87 pubmed publisher
  • western blot; human
Mori S, Kodaira M, Ito A, Okazaki M, Kawaguchi N, Hamada Y, et al. Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-β-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells. PLoS ONE. 2015;10:e0137486 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:800
Withofs N, Signolle N, Somja J, Lovinfosse P, Nzaramba E, Mievis F, et al. 18F-FPRGD2 PET/CT imaging of integrin αvβ3 in renal carcinomas: correlation with histopathology. J Nucl Med. 2015;56:361-4 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 7B
Farnoodian M, Kinter J, Yadranji Aghdam S, Zaitoun I, Sorenson C, Sheibani N. Expression of pigment epithelium-derived factor and thrombospondin-1 regulate proliferation and migration of retinal pigment epithelial cells. Physiol Rep. 2015;3: pubmed publisher
  • ELISA; Common quail; 1:1000; loading ...; fig 2
Scotti L, Abramovich D, Pascuali N, Durand L, Irusta G, de Zúñiga I, et al. Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS). Reprod Fertil Dev. 2016;28:690-9 pubmed publisher
  • flow cytometry; human; fig 1
Sugahara K, Braun G, de Mendoza T, Kotamraju V, French R, Lowy A, et al. Tumor-penetrating iRGD peptide inhibits metastasis. Mol Cancer Ther. 2015;14:120-8 pubmed publisher
  • flow cytometry; human
Horiguchi H, Endo M, Miyamoto Y, Sakamoto Y, Odagiri H, Masuda T, et al. Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase-phosphoinositide 3-kinase-dependent anti-apoptotic signaling. Cancer Sci. 2014;105:1550-9 pubmed publisher
  • immunohistochemistry - frozen section; human
Contois L, Akalu A, Caron J, Tweedie E, Cretu A, Henderson T, et al. Inhibition of tumor-associated αvβ3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo. Angiogenesis. 2015;18:31-46 pubmed publisher
  • immunocytochemistry; human
Cohen K, Flint N, Shalev S, Erez D, Baharal T, Davis P, et al. Thyroid hormone regulates adhesion, migration and matrix metalloproteinase 9 activity via ?v?3 integrin in myeloma cells. Oncotarget. 2014;5:6312-22 pubmed
  • flow cytometry; mouse
Shin E, Huang Q, Gurel Z, Sorenson C, Sheibani N. High glucose alters retinal astrocytes phenotype through increased production of inflammatory cytokines and oxidative stress. PLoS ONE. 2014;9:e103148 pubmed publisher
  • blocking or activating experiments; human; 10 ug/ml
Salvo E, Garasa S, Dotor J, Morales X, Pelaez R, Altevogt P, et al. Combined targeting of TGF-?1 and integrin ?3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer. Mol Cancer. 2014;13:112 pubmed publisher
  • blocking or activating experiments; human
Wei Y, Zhang Y, Cai H, Mirza A, Iorio R, Peeples M, et al. Roles of the putative integrin-binding motif of the human metapneumovirus fusion (f) protein in cell-cell fusion, viral infectivity, and pathogenesis. J Virol. 2014;88:4338-52 pubmed publisher
  • flow cytometry; mouse
Shin E, Sorenson C, Sheibani N. PEDF expression regulates the proangiogenic and proinflammatory phenotype of the lung endothelium. Am J Physiol Lung Cell Mol Physiol. 2014;306:L620-34 pubmed publisher
  • flow cytometry; mouse
Morrison M, Palenski T, Jamali N, Sheibani N, Sorenson C. Modulation of vascular cell function by bim expression. Int J Cell Biol. 2013;2013:297537 pubmed publisher
  • flow cytometry; human; 1:100
Faralli J, Gagen D, Filla M, Crotti T, Peters D. Dexamethasone increases ?v?3 integrin expression and affinity through a calcineurin/NFAT pathway. Biochim Biophys Acta. 2013;1833:3306-3313 pubmed publisher
  • blocking or activating experiments; human
  • flow cytometry; human
Tibaldi L, Leyman S, Nicolas A, Notebaert S, Dewulf M, Ngo T, et al. New blocking antibodies impede adhesion, migration and survival of ovarian cancer cells, highlighting MFGE8 as a potential therapeutic target of human ovarian carcinoma. PLoS ONE. 2013;8:e72708 pubmed publisher
  • immunoprecipitation; human
  • immunocytochemistry; human
Zhang C, Yang C, Wang R, Jiao Y, Ampah K, Wang X, et al. c-Abl Kinase Is a Regulator of ?v?3 Integrin Mediated Melanoma A375 Cell Migration. PLoS ONE. 2013;8:e66108 pubmed publisher
  • flow cytometry; human
Wang J, Wang L, Xia B, Yang C, Lai H, Chen X. BSP gene silencing inhibits migration, invasion, and bone metastasis of MDA-MB-231BO human breast cancer cells. PLoS ONE. 2013;8:e62936 pubmed publisher
  • immunocytochemistry; human
Ho Y, Kok S, Wang J, Lin L. Translucent titanium coating altered the composition of focal adhesions and promoted migration of osteoblast-like MG-63 cells on glass. J Biomed Mater Res A. 2014;102:1187-201 pubmed publisher
  • blocking or activating experiments; mouse
Lin L, Grimme J, Sun J, Lu S, Gai L, Cropek D, et al. The antagonistic roles of PDGF and integrin ?v?3 in regulating ROS production at focal adhesions. Biomaterials. 2013;34:3807-15 pubmed publisher
  • flow cytometry; mouse
Grutzmacher C, Park S, Zhao Y, Morrison M, Sheibani N, Sorenson C. Aberrant production of extracellular matrix proteins and dysfunction in kidney endothelial cells with a short duration of diabetes. Am J Physiol Renal Physiol. 2013;304:F19-30 pubmed publisher
Soriano A, De Cristofaro T, Di Palma T, Dotolo S, Gokulnath P, Izzo A, et al. PAX8 expression in high-grade serous ovarian cancer positively regulates attachment to ECM via Integrin β3. Cancer Cell Int. 2019;19:303 pubmed publisher
Koh K, Cao Y, Mangos S, Tardi N, Dande R, Lee H, et al. Nonimmune cell-derived ICOS ligand functions as a renoprotective αvβ3 integrin-selective antagonist. J Clin Invest. 2019;129:1713-1726 pubmed publisher
Nestić D, Uil T, Ma J, Roy S, Vellinga J, Baker A, et al. αvβ3 Integrin Is Required for Efficient Infection of Epithelial Cells with Human Adenovirus Type 26. J Virol. 2019;93: pubmed publisher
Thinn A, Wang Z, Zhou D, Zhao Y, Curtis B, Zhu J. Autonomous conformational regulation of β3 integrin and the conformation-dependent property of HPA-1a alloantibodies. Proc Natl Acad Sci U S A. 2018;115:E9105-E9114 pubmed publisher
Galbraith C, Davidson M, Galbraith J. Coupling integrin dynamics to cellular adhesion behaviors. Biol Open. 2018;7: pubmed publisher
Yosef G, Arkadash V, Papo N. Targeting the MMP-14/MMP-2/integrin αvβ3 axis with multispecific N-TIMP2-based antagonists for cancer therapy. J Biol Chem. 2018;293:13310-13326 pubmed publisher
Oyama M, Kariya Y, Kariya Y, Matsumoto K, Kanno M, Yamaguchi Y, et al. Biological role of site-specific O-glycosylation in cell adhesion activity and phosphorylation of osteopontin. Biochem J. 2018;475:1583-1595 pubmed publisher
Sun Q, Lesperance J, Wettersten H, Luterstein E, Derose Y, Welm A, et al. Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis. J Clin Invest. 2018;128:531-544 pubmed publisher
Stockis J, Li nart S, Colau D, Collignon A, Nishimura S, Sheppard D, et al. Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8. Proc Natl Acad Sci U S A. 2017;114:E10161-E10168 pubmed publisher
Portillo J, Muniz Feliciano L, Lopez Corcino Y, Lee S, Van Grol J, Parsons S, et al. Toxoplasma gondii induces FAK-Src-STAT3 signaling during infection of host cells that prevents parasite targeting by autophagy. PLoS Pathog. 2017;13:e1006671 pubmed publisher
Horiguchi H, Endo M, Kawane K, Kadomatsu T, Terada K, Morinaga J, et al. ANGPTL2 expression in the intestinal stem cell niche controls epithelial regeneration and homeostasis. EMBO J. 2017;36:409-424 pubmed publisher
Lamason R, Bastounis E, Kafai N, Serrano R, Del Alamo J, Theriot J, et al. Rickettsia Sca4 Reduces Vinculin-Mediated Intercellular Tension to Promote Spread. Cell. 2016;167:670-683.e10 pubmed publisher
Ng D, Humphries J, Byron A, Millon Frémillon A, Humphries M. Microtubule-dependent modulation of adhesion complex composition. PLoS ONE. 2014;9:e115213 pubmed publisher
Nakamura T, Shinriki S, Jono H, Ueda M, Nagata M, Guo J, et al. Osteopontin-integrin α(v)β(3) axis is crucial for 5-fluorouracil resistance in oral squamous cell carcinoma. FEBS Lett. 2015;589:231-9 pubmed publisher
Haubner R, Maschauer S, Einsiedel J, Eder I, Rangger C, Gmeiner P, et al. H-CRRETAWAC-OH, a lead structure for the development of radiotracer targeting integrin α5β1?. Biomed Res Int. 2014;2014:243185 pubmed publisher
Rylova S, Barnucz E, Fani M, Braun F, Werner M, Lassmann S, et al. Does imaging αvβ3 integrin expression with PET detect changes in angiogenesis during bevacizumab therapy?. J Nucl Med. 2014;55:1878-84 pubmed publisher
Leung C, Yeung T, Yip K, Pradeep S, Balasubramanian L, Liu J, et al. Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential. Nat Commun. 2014;5:5092 pubmed publisher
Hsiao C, Wang W, Kuo W, Chen H, Chen T, Hamann J, et al. CD97 inhibits cell migration in human fibrosarcoma cells by modulating TIMP-2/MT1- MMP/MMP-2 activity--role of GPS autoproteolysis and functional cooperation between the N- and C-terminal fragments. FEBS J. 2014;281:4878-91 pubmed publisher
Morjen M, Honoré S, Bazaa A, Abdelkafi Koubaa Z, Ellafi A, Mabrouk K, et al. PIVL, a snake venom Kunitz-type serine protease inhibitor, inhibits in vitro and in vivo angiogenesis. Microvasc Res. 2014;95:149-56 pubmed publisher
Zhan Y, Yu B, Wang Z, Zhang Y, Zhang H, Wu H, et al. A fiber-modified adenovirus co-expressing HSV-TK and Coli.NTR enhances antitumor activities in breast cancer cells. Int J Clin Exp Pathol. 2014;7:2850-60 pubmed
Fuhrmann A, Li J, Chien S, Engler A. Cation type specific cell remodeling regulates attachment strength. PLoS ONE. 2014;9:e102424 pubmed publisher
Kariya Y, Kanno M, Matsumoto Morita K, Konno M, Yamaguchi Y, Hashimoto Y. Osteopontin O-glycosylation contributes to its phosphorylation and cell-adhesion properties. Biochem J. 2014;463:93-102 pubmed publisher
Rui X, Mehrbod M, Van Agthoven J, Anand S, Xiong J, Mofrad M, et al. The ?-subunit regulates stability of the metal ion at the ligand-associated metal ion-binding site in ?3 integrins. J Biol Chem. 2014;289:23256-63 pubmed publisher
Nakajima T, Hirata M, Shearer T, Azuma M. Mechanism for laser-induced neovascularization in rat choroid: accumulation of integrin ? chain-positive cells and their ligands. Mol Vis. 2014;20:864-71 pubmed
Janib S, Gustafson J, Minea R, Swenson S, Liu S, Pastuszka M, et al. Multimeric disintegrin protein polymer fusions that target tumor vasculature. Biomacromolecules. 2014;15:2347-58 pubmed publisher
Ray A, Schaffner F, Janouskova H, Noulet F, Rognan D, Lelong Rebel I, et al. Single cell tracking assay reveals an opposite effect of selective small non-peptidic ?5?1 or ?v?3/?5 integrin antagonists in U87MG glioma cells. Biochim Biophys Acta. 2014;1840:2978-87 pubmed publisher
Klegerman M, Zou Y, Golunski E, Peng T, Huang S, McPherson D. Use of thermodynamic coupling between antibody-antigen binding and phospholipid acyl chain phase transition energetics to predict immunoliposome targeting affinity. J Liposome Res. 2014;24:216-22 pubmed publisher
Mor Cohen R, Rosenberg N, Averbukh Y, Seligsohn U, Lahav J. Disulfide bond exchanges in integrins ?IIb?3 and ?v?3 are required for activation and post-ligation signaling during clot retraction. Thromb Res. 2014;133:826-36 pubmed publisher
Podolnikova N, Yakovlev S, Yakubenko V, Wang X, Gorkun O, Ugarova T. The interaction of integrin ?IIb?3 with fibrin occurs through multiple binding sites in the ?IIb ?-propeller domain. J Biol Chem. 2014;289:2371-83 pubmed publisher
Aulakh G, Balachandran Y, Liu L, Singh B. Angiostatin inhibits activation and migration of neutrophils. Cell Tissue Res. 2014;355:375-96 pubmed publisher
Belcher J, Chen C, Nguyen J, Milbauer L, Abdulla F, Alayash A, et al. Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood. 2014;123:377-90 pubmed publisher
Wang R, Bi J, Ampah K, Ba X, Liu W, Zeng X. Lipid rafts control human melanoma cell migration by regulating focal adhesion disassembly. Biochim Biophys Acta. 2013;1833:3195-3205 pubmed publisher
Tome Y, Kimura H, Maehara H, Sugimoto N, Bouvet M, Tsuchiya H, et al. High lung-metastatic variant of human osteosarcoma cells, selected by passage of lung metastasis in nude mice, is associated with increased expression of ?(v)?(3) integrin. Anticancer Res. 2013;33:3623-7 pubmed
Bifulco K, Longanesi Cattani I, Liguori E, Arra C, Rea D, Masucci M, et al. A urokinase receptor-derived peptide inhibiting VEGF-dependent directional migration and vascular sprouting. Mol Cancer Ther. 2013;12:1981-93 pubmed publisher
Serres E, Debarbieux F, Stanchi F, Maggiorella L, Grall D, Turchi L, et al. Fibronectin expression in glioblastomas promotes cell cohesion, collective invasion of basement membrane in vitro and orthotopic tumor growth in mice. Oncogene. 2014;33:3451-62 pubmed publisher
Otagiri D, Yamada Y, Hozumi K, Katagiri F, Kikkawa Y, Nomizu M. Cell attachment and spreading activity of mixed laminin peptide-chitosan membranes. Biopolymers. 2013;100:751-9 pubmed publisher
Gagen D, Filla M, Clark R, LITON P, Peters D. Activated ?v?3 integrin regulates ?v?5 integrin-mediated phagocytosis in trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2013;54:5000-11 pubmed publisher
Schmieder A, Winter P, Williams T, Allen J, Hu G, Zhang H, et al. Molecular MR imaging of neovascular progression in the Vx2 tumor with ?v?3-targeted paramagnetic nanoparticles. Radiology. 2013;268:470-80 pubmed publisher
Long Q, Zhou M, Liu X, Du Y, Fan J, Li X, et al. Interaction of CCN1 with ?v?3 integrin induces P-glycoprotein and confers vinblastine resistance in renal cell carcinoma cells. Anticancer Drugs. 2013;24:810-7 pubmed publisher
Dall Angelo S, Zhang Q, Fleming I, Piras M, Schweiger L, O Hagan D, et al. Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of ?(v)?(3) integrin receptor. Org Biomol Chem. 2013;11:4551-8 pubmed publisher
Wang R, Bi J, Ampah K, Zhang C, Li Z, Jiao Y, et al. Lipid raft regulates the initial spreading of melanoma A375 cells by modulating ?1 integrin clustering. Int J Biochem Cell Biol. 2013;45:1679-89 pubmed publisher
Jim Leu S, Sung J, Huang M, Chen M, Tsai T. A novel anti-CCN1 monoclonal antibody suppresses Rac-dependent cytoskeletal reorganization and migratory activities in breast cancer cells. Biochem Biophys Res Commun. 2013;434:885-91 pubmed publisher
Conti L, Lanzardo S, Iezzi M, Montone M, Bolli E, Brioschi C, et al. Optical imaging detection of microscopic mammary cancer in ErbB-2 transgenic mice through the DA364 probe binding ?v ?3 integrins. Contrast Media Mol Imaging. 2013;8:350-60 pubmed publisher
Ruiz Ontañon P, Orgaz J, Aldaz B, Elosegui Artola A, Martino J, Berciano M, et al. Cellular plasticity confers migratory and invasive advantages to a population of glioblastoma-initiating cells that infiltrate peritumoral tissue. Stem Cells. 2013;31:1075-85 pubmed publisher
Rapraeger A, Ell B, Roy M, Li X, Morrison O, Thomas G, et al. Vascular endothelial-cadherin stimulates syndecan-1-coupled insulin-like growth factor-1 receptor and cross-talk between ?V?3 integrin and vascular endothelial growth factor receptor 2 at the onset of endothelial cell dissemination during angiogenesi. FEBS J. 2013;280:2194-206 pubmed publisher
Kemeny S, Cicalese S, Figueroa D, Clyne A. Glycated collagen and altered glucose increase endothelial cell adhesion strength. J Cell Physiol. 2013;228:1727-36 pubmed publisher
Krautkrämer E, Lehmann M, Bollinger V, Zeier M. Polar release of pathogenic Old World hantaviruses from renal tubular epithelial cells. Virol J. 2012;9:299 pubmed publisher
Majhen D, Richardson J, Vukelić B, Dodig I, Cindric M, Benihoud K, et al. The disulfide bond of an RGD4C motif inserted within the Hi loop of the adenovirus type 5 fiber protein is critical for retargeting to ?v -integrins. J Gene Med. 2012;14:788-97 pubmed publisher
Eberlein C, Kendrew J, McDaid K, Alfred A, Kang J, Jacobs V, et al. A human monoclonal antibody 264RAD targeting ?v?6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo. Oncogene. 2013;32:4406-16 pubmed publisher
Dong X, Mi L, Zhu J, Wang W, Hu P, Luo B, et al. ?(V)?(3) integrin crystal structures and their functional implications. Biochemistry. 2012;51:8814-28 pubmed publisher
Ravelli C, Mitola S, Corsini M, Presta M. Involvement of ?v?3 integrin in gremlin-induced angiogenesis. Angiogenesis. 2013;16:235-43 pubmed publisher
Iida J, Dorchak J, Lehman J, Clancy R, Luo C, Chen Y, et al. FH535 inhibited migration and growth of breast cancer cells. PLoS ONE. 2012;7:e44418 pubmed publisher
Cox R, Livesay S, Johnson M, Ohi M, Williams J. The human metapneumovirus fusion protein mediates entry via an interaction with RGD-binding integrins. J Virol. 2012;86:12148-60 pubmed publisher
Lescarbeau R, Seib F, Prewitz M, Werner C, Kaplan D. In vitro model of metastasis to bone marrow mediates prostate cancer castration resistant growth through paracrine and extracellular matrix factors. PLoS ONE. 2012;7:e40372 pubmed publisher
Zoppi N, Ritelli M, Colombi M. Type III and V collagens modulate the expression and assembly of EDA(+) fibronectin in the extracellular matrix of defective Ehlers-Danlos syndrome fibroblasts. Biochim Biophys Acta. 2012;1820:1576-87 pubmed publisher
Jin Z, Furukawa T, Claron M, Boturyn D, Coll J, Fukumura T, et al. Positron emission tomography imaging of tumor angiogenesis and monitoring of antiangiogenic efficacy using the novel tetrameric peptide probe 64Cu-cyclam-RAFT-c(-RGDfK-)4. Angiogenesis. 2012;15:569-80 pubmed publisher
Leksa V, Pfisterer K, Ondrovicová G, Binder B, Lakatosová S, Donner C, et al. Dissecting mannose 6-phosphate-insulin-like growth factor 2 receptor complexes that control activation and uptake of plasminogen in cells. J Biol Chem. 2012;287:22450-62 pubmed publisher
Bzowska M, Nogieć A, Skrzeczyńska Moncznik J, Mickowska B, Guzik K, Pryjma J. Oxidized LDLs inhibit TLR-induced IL-10 production by monocytes: a new aspect of pathogen-accelerated atherosclerosis. Inflammation. 2012;35:1567-84 pubmed publisher
Popugaeva E, Witkowski P, Schlegel M, Ulrich R, Auste B, Rang A, et al. Dobrava-Belgrade hantavirus from Germany shows receptor usage and innate immunity induction consistent with the pathogenicity of the virus in humans. PLoS ONE. 2012;7:e35587 pubmed publisher
Lee H, Koo B, Kim Y, Jeon O, Kim D. Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes. FASEB J. 2012;26:3084-95 pubmed publisher
Yoshimoto M, Hayakawa T, Mutoh M, Imai T, Tsuda K, Kimura S, et al. In vivo SPECT imaging with 111In-DOTA-c(RGDfK) to detect early pancreatic cancer in a hamster pancreatic carcinogenesis model. J Nucl Med. 2012;53:765-71 pubmed publisher
Li Y, Sun Q, Zhang H, Ren S, Liao Y, Wang Y, et al. A novel anti-platelet peptide (Z4A5) potential for glycoprotein IIb/IIIa inhibits platelet aggregation. Thromb Res. 2012;129:e217-22 pubmed publisher
Toupance S, Brassart B, Rabenoelina F, Ghoneim C, Vallar L, Polette M, et al. Elastin-derived peptides increase invasive capacities of lung cancer cells by post-transcriptional regulation of MMP-2 and uPA. Clin Exp Metastasis. 2012;29:511-22 pubmed publisher
Wan S, Lin C, Lu Y, Lei H, Anderson R, Lin Y. Endothelial cell surface expression of protein disulfide isomerase activates ?1 and ?3 integrins and facilitates dengue virus infection. J Cell Biochem. 2012;113:1681-91 pubmed publisher
Dasgupta S, Le A, Chavakis T, Rumbaut R, Thiagarajan P. Developmental endothelial locus-1 (Del-1) mediates clearance of platelet microparticles by the endothelium. Circulation. 2012;125:1664-72 pubmed publisher
Edkins A, Borland G, Acharya M, Cogdell R, Ozanne B, Cushley W. Differential regulation of monocyte cytokine release by ?V and ?(2) integrins that bind CD23. Immunology. 2012;136:241-51 pubmed publisher
Liu Z, Li W, Xu H, Huang X, Pan L, Ren Y, et al. In vivo pharmacokinetics, immunogenicity and mechanism of PEGylated antitumor polypeptide. Curr Pharm Des. 2012;18:1655-62 pubmed
Haseley A, Boone S, Wojton J, Yu L, Yoo J, Yu J, et al. Extracellular matrix protein CCN1 limits oncolytic efficacy in glioma. Cancer Res. 2012;72:1353-62 pubmed publisher
Wandel E, Saalbach A, Sittig D, Gebhardt C, Aust G. Thy-1 (CD90) is an interacting partner for CD97 on activated endothelial cells. J Immunol. 2012;188:1442-50 pubmed publisher
Knowles L, Malik G, Hood B, Conrads T, Pilch J. CLT1 targets angiogenic endothelium through CLIC1 and fibronectin. Angiogenesis. 2012;15:115-29 pubmed publisher
Sheibani N, Morrison M, Gurel Z, Park S, Sorenson C. BIM deficiency differentially impacts the function of kidney endothelial and epithelial cells through modulation of their local microenvironment. Am J Physiol Renal Physiol. 2012;302:F809-19 pubmed publisher
Lanzardo S, Conti L, Brioschi C, Bartolomeo M, Arosio D, Belvisi L, et al. A new optical imaging probe targeting ?V?3 integrin in glioblastoma xenografts. Contrast Media Mol Imaging. 2011;6:449-58 pubmed publisher
Case L, Waterman C. Adhesive F-actin waves: a novel integrin-mediated adhesion complex coupled to ventral actin polymerization. PLoS ONE. 2011;6:e26631 pubmed publisher
Borovjagin A, Dong J, Passineau M, Ren C, Lamani E, Mamaeva O, et al. Adenovirus gene transfer to amelogenesis imperfecta ameloblast-like cells. PLoS ONE. 2011;6:e24281 pubmed publisher
Kempkes C, Rattenholl A, Buddenkotte J, Strozyk E, Eberle J, Hausser A, et al. Proteinase-activated receptors 1 and 2 regulate invasive behavior of human melanoma cells via activation of protein kinase D1. J Invest Dermatol. 2012;132:375-84 pubmed publisher
Siegel A, Kimble Hill A, Garg S, Jordan R, Naumann C. Native ligands change integrin sequestering but not oligomerization in raft-mimicking lipid mixtures. Biophys J. 2011;101:1642-50 pubmed publisher
Razavian M, Marfatia R, Mongue Din H, Tavakoli S, Sinusas A, Zhang J, et al. Integrin-targeted imaging of inflammation in vascular remodeling. Arterioscler Thromb Vasc Biol. 2011;31:2820-6 pubmed publisher
Conradi J, Huber S, Gaus K, Mertink F, Royo Gracia S, Strijowski U, et al. Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins ?V?3 and ?5?1. Amino Acids. 2012;43:219-32 pubmed publisher
Ishigaki T, Imanaka Yoshida K, Shimojo N, Matsushima S, Taki W, Yoshida T. Tenascin-C enhances crosstalk signaling of integrin ?v?3/PDGFR-? complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells. J Cell Physiol. 2011;226:2617-24 pubmed publisher
Krautkrämer E, Grouls S, Stein N, Reiser J, Zeier M. Pathogenic old world hantaviruses infect renal glomerular and tubular cells and induce disassembling of cell-to-cell contacts. J Virol. 2011;85:9811-23 pubmed publisher
Zhu H, Zennadi R, Xu B, Eu J, Torok J, Telen M, et al. Impaired adenosine-5'-triphosphate release from red blood cells promotes their adhesion to endothelial cells: a mechanism of hypoxemia after transfusion. Crit Care Med. 2011;39:2478-86 pubmed publisher
Taherian A, Li X, Liu Y, Haas T. Differences in integrin expression and signaling within human breast cancer cells. BMC Cancer. 2011;11:293 pubmed publisher
Zaric J, Joseph J, Tercier S, Sengstag T, Ponsonnet L, Delorenzi M, et al. Identification of MAGI1 as a tumor-suppressor protein induced by cyclooxygenase-2 inhibitors in colorectal cancer cells. Oncogene. 2012;31:48-59 pubmed publisher
Kagaya H, Oba M, Miura Y, Koyama H, Ishii T, Shimada T, et al. Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions. Gene Ther. 2012;19:61-9 pubmed publisher
Bongiovanni M, Scanlon D, Gras S. Functional fibrils derived from the peptide TTR1-cycloRGDfK that target cell adhesion and spreading. Biomaterials. 2011;32:6099-110 pubmed publisher
Lei Y, Huang K, Gao C, Lau Q, Pan H, Xie K, et al. Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells. Mol Cell Proteomics. 2011;10:M110.005397 pubmed publisher
Ihara Y, Inai Y, Ikezaki M. Alteration of integrin-dependent adhesion and signaling in EMT-like MDCK cells established through overexpression of calreticulin. J Cell Biochem. 2011;112:2518-28 pubmed publisher
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product information
Catalog Number :
MAB1976Z
Subcategory :
Cell Structure
Product Name :
Anti-Integrin αVβ3 Antibody, clone LM609, Azide Free
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P06756
Host Name :
Mouse
Antigen :
Integrin αVβ3
Clone :
LM609
Conjugate :
Purified
Isotype :
IgG1
Product Description :
Anti-Integrin αVβ3 Antibody, clone LM609, Azide Free
Cross Reactivity :
Avian;Bovine;Canine;Chicken;Human;Monkey;Pig;Rabbit
Background :
The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor (Cheresh, 1991). The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. The adhesion receptor, integrin alphaVbeta3, appears to be selectively expressed on growing blood vessels and has been identified as a marker of angiogenic vascular tissue (Brooks, 1994). Due to its involvement in angiogenesis, integrin alphaVbeta3 is one of the most intensely studied of the integrin receptors.
ALT Names :
VitronectinReceptor;CD51/CD61;MAB1976
Immunogen :
Purified adhesion receptor from the human melanoma cell line M21 (Cheresh, 1987).
Specificity :
Reacts with the vitronectin receptor alphaVbeta3 complex, an RGD-directed adhesion receptor. LM609 has been demonstrated to block adhesion of a human melanoma cell line (M21) to vitronectin, fibrinogen and von Willebrand factor, as well as to a synthetic RGD containing peptide (Cheresh, 1987). In chick chorioallentoic membranes, LM609 was shown to block angiogenesis induced by bFGF and TNFalpha but had no effect on pre-existing vessels (Brooks, 1994). While LM609 does block cell attachment to RGD containing ligands, it does not interact directly with the RGD binding site. Instead, LM609 appears to be an allosteric inhibitor of integrin alphaVbeta3, which binds to a conformational epitope resulting from the post-translational association of the alphaV and beta3 subunits.
Package Size :
100 μg
Uses :
Flow Cytometry;Immunohistochemistry;Immunoprecipitation;Affects Function
Storage :
Maintain at 2–8°C in undiluted aliquots for up to 6 months.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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