Integrin αVβ3 Antibody, clone LM609, Alexa Fluor®488 conjugated | EMD Millipore MAB1976X product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Integrin αVβ3 Antibody, clone LM609, Alexa Fluor®488 conjugated

catalog :

MAB1976X

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

LM609

The same clone is also sold as:

Abcam: ab190147

reactivity :

human

application :

immunocytochemistry, flow cytometry

citations: 126

Reference
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product information

Catalog Number :

MAB1976X

Subcategory :

Cell Structure

Product Name :

Anti-Integrin αVβ3 Antibody, clone LM609, Alexa Fluor®488 conjugated

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P06756

Host Name :

Mouse

Antigen :

Integrin αVβ3

Clone :

LM609

Conjugate :

AlexaFluor®488

Isotype :

IgG1

Product Description :

Anti-Integrin αVβ3 Antibody, clone LM609, Alexa Fluor®488 conjugated

Cross Reactivity :

Avian;Bovine;Canine;Chicken;Human;Monkey;Pig;Rabbit

Background :

The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor (Cheresh, 1991). The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. The adhesion receptor, integrin alphaVbeta3, appears to be selectively expressed on growing blood vessels and has been identified as a marker of angiogenic vascular tissue (Brooks, 1994). Due to its involvement in angiogenesis, integrin alphaVbeta3 is one of the most intensely studied of the integrin receptors.

ALT Names :

Vitronectin Receptor; CD51/61

Immunogen :

Purified adhesion receptor from the human melanoma cell line M21 (Cheresh, 1987).

Specificity :

Reacts with the vitronectin receptor alphaVbeta3 complex, an RGD-directed adhesion receptor. LM609 has been demonstrated to block adhesion of a human melanoma cell line (M21) to vitronectin, fibrinogen and von Willebrand factor, as well as to a synthetic RGD containing peptide (Cheresh, 1987). In chick chorioallentoic membranes, LM609 was shown to block angiogenesis induced by bFGF and TNFalpha but had no effect on pre-existing vessels (Brooks, 1994). While LM609 does block cell attachment to RGD containing ligands, it does not interact directly with the RGD binding site. Instead, LM609 appears to be an allosteric inhibitor of integrin alphaVbeta3, which binds to a conformational epitope resulting from the post-translational association of the alphaV and beta3 subunits.

Package Size :

100 μg

Uses :

Flow Cytometry;Immunofluorescence

Storage :

Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.