Integrin β4 Antibody, clone 3E1 | EMD Millipore MAB1964 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Integrin β4 Antibody, clone 3E1

catalog :

MAB1964

quantity :

100 μL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3E1

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments

citations: 12

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 3b	Bandeira F, Goh T, Setiawan M, Yam G, Mehta J. Cellular therapy of corneal epithelial defect by adipose mesenchymal stem cell-derived epithelial progenitors. Stem Cell Res Ther. 2020;11:14 pubmed publisher
flow cytometry; human immunocytochemistry; human	Sarper M, Allen M, Gomm J, Haywood L, Decock J, Thirkettle S, et al. Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function. Breast Cancer Res. 2017;19:33 pubmed publisher
western blot; human	Tang K, Cai Y, Joshi S, Tovar E, Tucker S, Maddipati K, et al. Convergence of eicosanoid and integrin biology: 12-lipoxygenase seeks a partner. Mol Cancer. 2015;14:111 pubmed publisher
immunocytochemistry; human	Rubashkin M, Cassereau L, Bainer R, DuFort C, Yui Y, Ou G, et al. Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate. Cancer Res. 2014;74:4597-611 pubmed publisher
immunocytochemistry; human; 1:250	Dolega M, Wagh J, Gerbaud S, Kermarrec F, Alcaraz J, Martin D, et al. Facile bench-top fabrication of enclosed circular microchannels provides 3D confined structure for growth of prostate epithelial cells. PLoS ONE. 2014;9:e99416 pubmed publisher
immunohistochemistry - frozen section; human; 1:100	Langton A, Sherratt M, Sellers W, Griffiths C, Watson R. Geographical ancestry is a key determinant of epidermal morphology and dermal composition. Br J Dermatol. 2014;171:274-82 pubmed publisher
flow cytometry; human	Kligys K, Wu Y, Hamill K, Lewandowski K, Hopkinson S, Budinger G, et al. Laminin-332 and ?3?1 integrin-supported migration of bronchial epithelial cells is modulated by fibronectin. Am J Respir Cell Mol Biol. 2013;49:731-40 pubmed publisher
blocking or activating experiments; human	Hiroyasu S, Ozawa T, Kobayashi H, Ishii M, Aoyama Y, Kitajima Y, et al. Bullous pemphigoid IgG induces BP180 internalization via a macropinocytic pathway. Am J Pathol. 2013;182:828-40 pubmed publisher
	Sharma C, Rabinovitz I, Hemler M. Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin ?6?4. Cell Mol Life Sci. 2012;69:2233-44 pubmed publisher
	Chen A, Cuevas I, Kenny P, Miyake H, Mace K, Ghajar C, et al. Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity. Cancer Res. 2009;69:6721-9 pubmed publisher
	Imbalzano K, Tatarkova I, Imbalzano A, Nickerson J. Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane culture. Cancer Cell Int. 2009;9:7 pubmed publisher
	Solomon L, Yerke L, Kumar V. Differentiation of mucous membrane pemphigoid subgroups with confocal imaging. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:790-5 pubmed

product information

Catalog Number :

MAB1964

Subcategory :

Cell Structure

Product Name :

Anti-Integrin β4 Antibody, clone 3E1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P16144

Host Name :

Mouse

Antigen :

Integrin β4

Clone :

3E1

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-Integrin β4 Antibody, clone 3E1

Cross Reactivity :

Human

Background :

Integrin beta 4 is a glycoprotein which associates with the a6 integrin to form the a6/b4 complex. Integrin alpha 6/beta 4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Defects in Integrin beta 4 gene are a cause of epidermolysis bullosa letalis with pyloric atresia (EB PA); also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus. Moreover, defects in Integrin beta 4 gene are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). This nonlethal form of junctional epidermolysis bullosa is characterized by life long blistering of the skin, associated with hair and tooth abnormalities.

ALT Names :

CD104

Specificity :

Reacts with Human beta4 integrin. The antigen is present on epithelial cells.

Package Size :

100 μL

Uses :

Flow Cytometry;Immunocytochemistry;Immunohistochemistry;Immunoprecipitation

Storage :

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.