This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Integrin α5 Antibody, clone P1D6
catalog :
MAB1956
quantity :
100 μL
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
P1D6

The same clone is also sold as:
reactivity :
human
application :
immunohistochemistry, flow cytometry, immunohistochemistry - frozen section, proximity ligation assay, blocking or activating experiments
citations: 30
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; loading ...; fig 3
  • immunohistochemistry - frozen section; human; loading ...; fig 1
  • flow cytometry; human; loading ...; fig 2
Storm R, Persson B, Skalman L, Frängsmyr L, Lindström M, Rankin G, et al. Human Adenovirus Type 37 Uses αVβ1 and α3β1 Integrins for Infection of Human Corneal Cells. J Virol. 2017;91: pubmed publisher
  • blocking or activating experiments; human; loading ...; fig s1c
Kolanowski S, van Schijndel G, Van Ham S, ten Brinke A. Adaptation to replating of dendritic cells synergizes with Toll-like receptor stimuli and enhances the pro-inflammatory cytokine profile. Cytotherapy. 2016;18:902-10 pubmed publisher
  • immunohistochemistry; human; fig 5a
Walker L, Hussein H, Akula S. Subcellular fractionation method to study endosomal trafficking of Kaposi's sarcoma-associated herpesvirus. Cell Biosci. 2016;6:1 pubmed publisher
  • proximity ligation assay; human; 1:1000; fig s3
Fiore V, Strane P, Bryksin A, White E, Hagood J, Barker T. Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction. J Cell Biol. 2015;211:173-90 pubmed publisher
  • flow cytometry; human; 1:50
Bassagañas S, Carvalho S, Dias A, Pérez Garay M, Ortiz M, Figueras J, et al. Pancreatic cancer cell glycosylation regulates cell adhesion and invasion through the modulation of ?2?1 integrin and E-cadherin function. PLoS ONE. 2014;9:e98595 pubmed publisher
  • blocking or activating experiments; human; 10 ug/ml
  • flow cytometry; human; 2 ug/25 x104cells
Stampolidis P, Ullrich A, Iacobelli S. LGALS3BP, lectin galactoside-binding soluble 3 binding protein, promotes oncogenic cellular events impeded by antibody intervention. Oncogene. 2015;34:39-52 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:100
  • flow cytometry; human
Bridgen D, Gilchrist C, Richardson W, Isaacs R, Brown C, Yang K, et al. Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc. J Orthop Res. 2013;31:1661-7 pubmed publisher
Hui T, Sørensen E, Rittling S. Osteopontin binding to the alpha 4 integrin requires highest affinity integrin conformation, but is independent of post-translational modifications of osteopontin. Matrix Biol. 2015;41:19-25 pubmed publisher
Juengel E, Makarevic J, Reiter M, Mani J, Tsaur I, Bartsch G, et al. Resistance to the mTOR inhibitor temsirolimus alters adhesion and migration behavior of renal cell carcinoma cells through an integrin ?5- and integrin ?3-dependent mechanism. Neoplasia. 2014;16:291-300 pubmed publisher
Walker L, Hussein H, Akula S. Disintegrin-like domain of glycoprotein B regulates Kaposi's sarcoma-associated herpesvirus infection of cells. J Gen Virol. 2014;95:1770-82 pubmed publisher
Tanaka R, Seki Y, Saito Y, Kamiya S, Fujita M, Okutsu H, et al. Tenascin-C-derived peptide TNIIIA2 highly enhances cell survival and platelet-derived growth factor (PDGF)-dependent cell proliferation through potentiated and sustained activation of integrin ?5?1. J Biol Chem. 2014;289:17699-708 pubmed publisher
Katagiri F, Takagi M, Nakamura M, Tanaka Y, Hozumi K, Kikkawa Y, et al. Screening of integrin-binding peptides in a laminin peptide library derived from the mouse laminin ? chain short arm regions. Arch Biochem Biophys. 2014;550-551:33-41 pubmed publisher
Wei Y, Zhang Y, Cai H, Mirza A, Iorio R, Peeples M, et al. Roles of the putative integrin-binding motif of the human metapneumovirus fusion (f) protein in cell-cell fusion, viral infectivity, and pathogenesis. J Virol. 2014;88:4338-52 pubmed publisher
Kiwanuka E, Andersson L, Caterson E, Junker J, Gerdin B, Eriksson E. CCN2 promotes keratinocyte adhesion and migration via integrin ?5?1. Exp Cell Res. 2013;319:2938-46 pubmed publisher
Vial D, McKeown Longo P. Epidermal growth factor (EGF) regulates ?5?1 integrin activation state in human cancer cell lines through the p90RSK-dependent phosphorylation of filamin A. J Biol Chem. 2012;287:40371-80 pubmed publisher
Tsaur I, Makarevic J, Juengel E, Gasser M, Waaga Gasser A, Kurosch M, et al. Resistance to the mTOR-inhibitor RAD001 elevates integrin ?2- and ?1-triggered motility, migration and invasion of prostate cancer cells. Br J Cancer. 2012;107:847-55 pubmed publisher
Matsunaga T, Fukai F, Kameda T, Shide K, Shimoda H, Torii E, et al. Potentiated activation of VLA-4 and VLA-5 accelerates proplatelet-like formation. Ann Hematol. 2012;91:1633-43 pubmed publisher
Ma J, Cui W, He S, Duan Y, Heng L, Wang L, et al. Human U87 astrocytoma cell invasion induced by interaction of ?ig-h3 with integrin ?5?1 involves calpain-2. PLoS ONE. 2012;7:e37297 pubmed publisher
Li Q, Ding X, Thomas J, Harding C, Pecora N, Ziady A, et al. Rv2468c, a novel Mycobacterium tuberculosis protein that costimulates human CD4+ T cells through VLA-5. J Leukoc Biol. 2012;91:311-20 pubmed publisher
Sabari J, Lax D, Connors D, Brotman I, Mindrebo E, Butler C, et al. Fibronectin matrix assembly suppresses dispersal of glioblastoma cells. PLoS ONE. 2011;6:e24810 pubmed publisher
Sánchez Cortés J, Mrksich M. Using self-assembled monolayers to understand ?8?1-mediated cell adhesion to RGD and FEI motifs in nephronectin. ACS Chem Biol. 2011;6:1078-86 pubmed publisher
Teo J, Ng R, Ng C, Lin A. Surface characteristics of acrylic modified polysulfone membranes improves renal proximal tubule cell adhesion and spreading. Acta Biomater. 2011;7:2060-9 pubmed publisher
Morgan M, Jazayeri M, Ramsay A, Thomas G, Boulanger M, Hart I, et al. Psoriasin (S100A7) associates with integrin ?6 subunit and is required for ?v?6-dependent carcinoma cell invasion. Oncogene. 2011;30:1422-35 pubmed publisher
Kessentini Zouari R, Jebali J, Taboubi S, Srairi Abid N, Morjen M, Kallech Ziri O, et al. CC-PLA2-1 and CC-PLA2-2, two Cerastes cerastes venom-derived phospholipases A2, inhibit angiogenesis both in vitro and in vivo. Lab Invest. 2010;90:510-9 pubmed publisher
Chai D, Arner E, Griggs D, Grodzinsky A. Alphav and beta1 integrins regulate dynamic compression-induced proteoglycan synthesis in 3D gel culture by distinct complementary pathways. Osteoarthritis Cartilage. 2010;18:249-56 pubmed publisher
Westhorpe C, Zhou J, Webster N, Kalionis B, Lewin S, Jaworowski A, et al. Effects of HIV-1 infection in vitro on transendothelial migration by monocytes and monocyte-derived macrophages. J Leukoc Biol. 2009;85:1027-35 pubmed publisher
Holledge M, Millward Sadler S, Nuki G, Salter D. Mechanical regulation of proteoglycan synthesis in normal and osteoarthritic human articular chondrocytes--roles for alpha5 and alphaVbeta5 integrins. Biorheology. 2008;45:275-88 pubmed
Fukushima Y, Tamura M, Nakagawa H, Itoh K. Induction of glioma cell migration by vitronectin in human serum and cerebrospinal fluid. J Neurosurg. 2007;107:578-85 pubmed
McNally A, Macewan S, Anderson J. alpha subunit partners to beta1 and beta2 integrins during IL-4-induced foreign body giant cell formation. J Biomed Mater Res A. 2007;82:568-74 pubmed
Mazzocca A, Coppari R, De Franco R, Cho J, Libermann T, Pinzani M, et al. A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions. Cancer Res. 2005;65:4728-38 pubmed
product information
Catalog Number :
MAB1956
Subcategory :
Cell Structure
Product Name :
Anti-Integrin α5 Antibody, clone P1D6
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P08648
Host Name :
Mouse
Antigen :
Integrin α5
Clone :
P1D6
Conjugate :
Ascites
Isotype :
IgG3
Product Description :
Anti-Integrin α5 Antibody, clone P1D6
Cross Reactivity :
Human
ALT Names :
CD49e
Specificity :
Reacts with Human alpha 5 integrin. Reactivity with other species is unknown.
Package Size :
100 μL
Uses :
Immunohistochemistry;Affects Function
Storage :
Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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