This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Integrin α2 Antibody, clone P1E6, azide free
catalog :
MAB1950Z
quantity :
100 μg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
P1E6

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments
citations: 45
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; loading ...; fig 3
  • immunohistochemistry - frozen section; human; loading ...; fig 1
  • flow cytometry; human; loading ...; fig 2
Storm R, Persson B, Skalman L, Frängsmyr L, Lindström M, Rankin G, et al. Human Adenovirus Type 37 Uses αVβ1 and α3β1 Integrins for Infection of Human Corneal Cells. J Virol. 2017;91: pubmed publisher
  • flow cytometry; human
Mori S, Kodaira M, Ito A, Okazaki M, Kawaguchi N, Hamada Y, et al. Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-β-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells. PLoS ONE. 2015;10:e0137486 pubmed publisher
  • blocking or activating experiments; human; fig 3
Artym V, Swatkoski S, Matsumoto K, Campbell C, Petrie R, Dimitriadis E, et al. Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network. J Cell Biol. 2015;208:331-50 pubmed publisher
  • blocking or activating experiments; human; 1:50
  • flow cytometry; human; 1:200
Bassagañas S, Carvalho S, Dias A, Pérez Garay M, Ortiz M, Figueras J, et al. Pancreatic cancer cell glycosylation regulates cell adhesion and invasion through the modulation of ?2?1 integrin and E-cadherin function. PLoS ONE. 2014;9:e98595 pubmed publisher
  • flow cytometry; human
Iida J, Clancy R, Dorchak J, Somiari R, Somiari S, Cutler M, et al. DNA aptamers against exon v10 of CD44 inhibit breast cancer cell migration. PLoS ONE. 2014;9:e88712 pubmed publisher
  • blocking or activating experiments; human; 10 ug/ml
  • flow cytometry; human; 2 ug/25 x104cells
Stampolidis P, Ullrich A, Iacobelli S. LGALS3BP, lectin galactoside-binding soluble 3 binding protein, promotes oncogenic cellular events impeded by antibody intervention. Oncogene. 2015;34:39-52 pubmed publisher
  • western blot; human; fig 5
Costa P, Scales T, Ivaska J, Parsons M. Integrin-specific control of focal adhesion kinase and RhoA regulates membrane protrusion and invasion. PLoS ONE. 2013;8:e74659 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:100
  • flow cytometry; human
Bridgen D, Gilchrist C, Richardson W, Isaacs R, Brown C, Yang K, et al. Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc. J Orthop Res. 2013;31:1661-7 pubmed publisher
  • immunocytochemistry; human
Ho Y, Kok S, Wang J, Lin L. Translucent titanium coating altered the composition of focal adhesions and promoted migration of osteoblast-like MG-63 cells on glass. J Biomed Mater Res A. 2014;102:1187-201 pubmed publisher
  • flow cytometry; human
Kligys K, Wu Y, Hamill K, Lewandowski K, Hopkinson S, Budinger G, et al. Laminin-332 and ?3?1 integrin-supported migration of bronchial epithelial cells is modulated by fibronectin. Am J Respir Cell Mol Biol. 2013;49:731-40 pubmed publisher
  • immunocytochemistry; human
Jakubowski P, Calvete J, Eble J, Lazarovici P, Marcinkiewicz C. Identification of inhibitors of ?2?1 integrin, members of C-lectin type proteins, in Echis sochureki venom. Toxicol Appl Pharmacol. 2013;269:34-42 pubmed publisher
Naci D, Aoudjit F. Alpha2beta1 integrin promotes T cell survival and migration through the concomitant activation of ERK/Mcl-1 and p38 MAPK pathways. Cell Signal. 2014;26:2008-15 pubmed publisher
Katagiri F, Hara T, Yamada Y, Urushibata S, Hozumi K, Kikkawa Y, et al. Biological activities of the homologous loop regions in the laminin ? chain LG modules. Biochemistry. 2014;53:3699-708 pubmed publisher
Katagiri F, Takagi M, Nakamura M, Tanaka Y, Hozumi K, Kikkawa Y, et al. Screening of integrin-binding peptides in a laminin peptide library derived from the mouse laminin ? chain short arm regions. Arch Biochem Biophys. 2014;550-551:33-41 pubmed publisher
Yao Y, Chen Z, Norris E, Strickland S. Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity. Nat Commun. 2014;5:3413 pubmed publisher
Zwolanek D, Veit G, Eble J, Gullberg D, Ruggiero F, Heino J, et al. Collagen XXII binds to collagen-binding integrins via the novel motifs GLQGER and GFKGER. Biochem J. 2014;459:217-27 pubmed publisher
Otagiri D, Yamada Y, Hozumi K, Katagiri F, Kikkawa Y, Nomizu M. Cell attachment and spreading activity of mixed laminin peptide-chitosan membranes. Biopolymers. 2013;100:751-9 pubmed publisher
Balasubramaniam S, Comstock C, Ertel A, Jeong K, Stallcup M, Addya S, et al. Aberrant BAF57 signaling facilitates prometastatic phenotypes. Clin Cancer Res. 2013;19:2657-67 pubmed publisher
Stergiou L, Bauer M, Mair W, Bausch Fluck D, Drayman N, Wollscheid B, et al. Integrin-mediated signaling induced by simian virus 40 leads to transient uncoupling of cortical actin and the plasma membrane. PLoS ONE. 2013;8:e55799 pubmed publisher
Wong W, Sigvardsson M, Astrand Grundström I, Hogge D, Larsson J, Qian H, et al. Expression of integrin ?2 receptor in human cord blood CD34+CD38-CD90+ stem cells engrafting long-term in NOD/SCID-IL2R?(c) null mice. Stem Cells. 2013;31:360-71 pubmed publisher
Bazan Socha S, Zuk J, Plutecka H, Marcinkiewicz C, Zareba L, Musial J. Collagen receptors ?(1)?(1) and ?(2)?(1) integrins are involved in transmigration of peripheral blood eosinophils, but not mononuclear cells through human microvascular endothelial cells monolayer. J Physiol Pharmacol. 2012;63:373-9 pubmed
Scales T, Jayo A, Obara B, Holt M, Hotchin N, Berditchevski F, et al. ?3?1 integrins regulate CD151 complex assembly and membrane dynamics in carcinoma cells within 3D environments. Oncogene. 2013;32:3965-79 pubmed publisher
Cox R, Livesay S, Johnson M, Ohi M, Williams J. The human metapneumovirus fusion protein mediates entry via an interaction with RGD-binding integrins. J Virol. 2012;86:12148-60 pubmed publisher
Tsaur I, Makarevic J, Juengel E, Gasser M, Waaga Gasser A, Kurosch M, et al. Resistance to the mTOR-inhibitor RAD001 elevates integrin ?2- and ?1-triggered motility, migration and invasion of prostate cancer cells. Br J Cancer. 2012;107:847-55 pubmed publisher
Hozumi K, Ishikawa M, Hayashi T, Yamada Y, Katagiri F, Kikkawa Y, et al. Identification of cell adhesive sequences in the N-terminal region of the laminin ?2 chain. J Biol Chem. 2012;287:25111-22 pubmed publisher
Kligys K, Wu Y, Hopkinson S, Kaur S, Platanias L, Jones J. ?6?4 integrin, a master regulator of expression of integrins in human keratinocytes. J Biol Chem. 2012;287:17975-84 pubmed publisher
Naci D, El Azreq M, Chetoui N, Lauden L, Sigaux F, Charron D, et al. ?2?1 integrin promotes chemoresistance against doxorubicin in cancer cells through extracellular signal-regulated kinase (ERK). J Biol Chem. 2012;287:17065-76 pubmed publisher
Katagiri F, Ishikawa M, Yamada Y, Hozumi K, Kikkawa Y, Nomizu M. Screening of integrin-binding peptides from the laminin ?4 and ?5 chain G domain peptide library. Arch Biochem Biophys. 2012;521:32-42 pubmed publisher
Erfle H, Eskova A, Reymann J, Starkuviene V. Cell arrays and high-content screening. Methods Mol Biol. 2011;785:277-87 pubmed publisher
Yamada Y, Katagiri F, Hozumi K, Kikkawa Y, Nomizu M. Cell behavior on protein matrices containing laminin ?1 peptide AG73. Biomaterials. 2011;32:4327-35 pubmed publisher
Steele M, Schieler A, Kelley P, Tempero R. ?1 integrin regulates MMP-10 dependant tubulogenesis in human lymphatic endothelial cells. Matrix Biol. 2011;30:218-24 pubmed publisher
Teo J, Ng R, Ng C, Lin A. Surface characteristics of acrylic modified polysulfone membranes improves renal proximal tubule cell adhesion and spreading. Acta Biomater. 2011;7:2060-9 pubmed publisher
Chen S, Tsai Y, Wu C, Liao S, Wu L, Chang C, et al. Streptococcal collagen-like surface protein 1 promotes adhesion to the respiratory epithelial cell. BMC Microbiol. 2010;10:320 pubmed publisher
Hsiao C, Chen H, Chang G, Lin H. GPS autoproteolysis is required for CD97 to up-regulate the expression of N-cadherin that promotes homotypic cell-cell aggregation. FEBS Lett. 2011;585:313-8 pubmed publisher
Wright S, Parham C, Lee B, Clarke D, Auckland L, Johnston J, et al. Perlecan domain V inhibits ?2 integrin-mediated amyloid-? neurotoxicity. Neurobiol Aging. 2012;33:1379-88 pubmed publisher
Hozumi K, Akizuki T, Yamada Y, Hara T, Urushibata S, Katagiri F, et al. Cell adhesive peptide screening of the mouse laminin ?1 chain G domain. Arch Biochem Biophys. 2010;503:213-22 pubmed publisher
Alexopoulou A, Leao M, Caballero O, Da Silva L, Reid L, Lakhani S, et al. Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines. Breast Cancer Res. 2010;12:R51 pubmed publisher
Stratman A, Saunders W, Sacharidou A, Koh W, Fisher K, Zawieja D, et al. Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices. Blood. 2009;114:237-47 pubmed publisher
Fiorilli P, Partridge D, Staniszewska I, Wang J, Grabacka M, So K, et al. Integrins mediate adhesion of medulloblastoma cells to tenascin and activate pathways associated with survival and proliferation. Lab Invest. 2008;88:1143-56 pubmed publisher
Paszkiewicz Gadek A, Porowska H, Lemancewicz D, Wolczynski S, Gindzienski A. The influence of N- and O-glycosylation inhibitors on the glycosylation profile of cellular membrane proteins and adhesive properties of carcinoma cell lines. Int J Mol Med. 2006;17:669-74 pubmed
Wright S, Malinin N, Powell K, Yednock T, Rydel R, Griswold Prenner I. Alpha2beta1 and alphaVbeta1 integrin signaling pathways mediate amyloid-beta-induced neurotoxicity. Neurobiol Aging. 2007;28:226-37 pubmed
Yuen H, Ziober A, Gopal P, Nasrallah I, Falls E, Meneguzzi G, et al. Suppression of laminin-5 expression leads to increased motility, tumorigenicity, and invasion. Exp Cell Res. 2005;309:198-210 pubmed
Bernard Trifilo J, Kramar E, Torp R, Lin C, Pineda E, Lynch G, et al. Integrin signaling cascades are operational in adult hippocampal synapses and modulate NMDA receptor physiology. J Neurochem. 2005;93:834-49 pubmed
Wang T, Ward Y, Tian L, Lake R, Guedez L, Stetler Stevenson W, et al. CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells. Blood. 2005;105:2836-44 pubmed
Kikkawa Y, Virtanen I, Miner J. Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane. J Cell Biol. 2003;161:187-96 pubmed
product information
Catalog Number :
MAB1950Z
Subcategory :
Cell Structure
Product Name :
Anti-Integrin α2 Antibody, clone P1E6, azide free
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P17301
Host Name :
Mouse
Antigen :
Integrin α2
Clone :
P1E6
Conjugate :
Purified
Isotype :
IgG1
Product Description :
Anti-Integrin α2 Antibody, clone P1E6, azide free
Cross Reactivity :
Human
ALT Names :
CD49b;MAB1950
Specificity :
Recognizes Alpha 2 integrin.
Package Size :
100 μg
Uses :
Immunocytochemistry;Immunohistochemistry;Affects Function
Storage :
Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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