Human MT1-MMP catalytic domain Antibody, clone 3G4.2 | EMD Millipore MAB1767 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Human MT1-MMP catalytic domain Antibody, clone 3G4.2

catalog :

MAB1767

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3G4.2

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; rat; loading ...; fig 3a	Nishihara T, Remacle A, Angert M, Shubayev I, Shiryaev S, Liu H, et al. Matrix metalloproteinase-14 both sheds cell surface neuronal glial antigen 2 (NG2) proteoglycan on macrophages and governs the response to peripheral nerve injury. J Biol Chem. 2015;290:3693-707 pubmed publisher
western blot; human; fig 7	Golubkov V, Strongin A. Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7). J Biol Chem. 2012;287:42009-18 pubmed publisher
	Pratt J, Iddir M, Bourgault S, Annabi B. Evidence of MTCBP-1 interaction with the cytoplasmic domain of MT1-MMP: Implications in the autophagy cell index of high-grade glioblastoma. Mol Carcinog. 2016;55:148-60 pubmed publisher
	Bodnar M, Szylberg L, Kazmierczak W, Marszalek A. Differentiated expression of membrane type metalloproteinases (MMP-14, MMP-15) and pro-MMP2 in laryngeal squamous cell carcinoma. A novel mechanism. J Oral Pathol Med. 2013;42:267-74 pubmed publisher
	Golubkov V, Aleshin A, Strongin A. Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects. J Biol Chem. 2011;286:20970-6 pubmed publisher
	Smith Pearson P, Greuber E, Yogalingam G, Pendergast A. Abl kinases are required for invadopodia formation and chemokine-induced invasion. J Biol Chem. 2010;285:40201-11 pubmed publisher
	Kim S, Huang W, Mottillo E, Sohail A, Ham Y, Conley LaComb M, et al. Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP. Biochim Biophys Acta. 2010;1803:1287-97 pubmed publisher
	Duriseti S, Goetz D, Hostetter D, LeBeau A, Wei Y, Craik C. Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration. J Biol Chem. 2010;285:26878-88 pubmed publisher

product information

Catalog Number :

MAB1767

Subcategory :

Cell Structure

Product Name :

Anti-Human MT1-MMP catalytic domain Antibody, clone 3G4.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P50281

Host Name :

Mouse

Antigen :

Human MT1-MMP catalytic domain

Clone :

3G4.2

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-Human MT1-MMP catalytic domain Antibody, clone 3G4.2

Cross Reactivity :

Human

Background :

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP-14 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. MT1-MMP is capable of mediating pericellular proteolysis of extracellular matrix components and is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix. This protein also activates MMP2 protein, and this activity may be involved in tumor invasion.

ALT Names :

MMP-14

Immunogen :

Recombinant protein containing the catalytic domain of human MT1-MMP.

Specificity :

Clone 3G4.2 recognizes the catalytic domain of MT1-MMP, identifying the active form of the protein. MW is approximately 60 kDa.

Package Size :

100 µg

Uses :

Western Blotting;Immunocytochemistry;Immunohistochemistry

Storage :

1 year at 2-8°C from date of shipment