Filamin A Antibody, clone TI10 | EMD Millipore MAB1680 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Filamin A Antibody, clone TI10

catalog :

MAB1680

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TI10

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 20

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; loading ...; fig 4a western blot; human; 1:1000; loading ...; fig 1a	Wang K, Zhu T, Zhao R. Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration. Mol Med Rep. 2019;20:3671-3678 pubmed publisher
immunocytochemistry; human; 1:100; fig 1 western blot; human; 1:1000; fig 1	Justa Schuch D, Silva Garcia M, Pilla E, Engelke M, Kilisch M, Lenz C, et al. DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk. elife. 2016;5: pubmed publisher
western blot; human; 1:500	Kiss A, Gong X, Kowalewski J, Shafqat Abbasi H, StrÃ¶mblad S, Lock J. Non-monotonic cellular responses to heterogeneity in talin protein expression-level. Integr Biol (Camb). 2015;7:1171-85 pubmed publisher
immunocytochemistry; human; 1:2000 western blot; human	Iguchi Y, Ishihara S, Uchida Y, Tajima K, Mizutani T, Kawabata K, et al. Filamin B Enhances the Invasiveness of Cancer Cells into 3D Collagen Matrices. Cell Struct Funct. 2015;40:61-7 pubmed publisher
	Tirupula K, Ithychanda S, Mohan M, Naga Prasad S, Qin J, Karnik S. G protein-coupled receptors directly bind filamin A with high affinity and promote filamin phosphorylation. Biochemistry. 2015;54:6673-83 pubmed publisher
	Di Donato M, Bilancio A, D Amato L, Claudiani P, Oliviero M, Barone M, et al. Cross-talk between androgen receptor/filamin A and TrkA regulates neurite outgrowth in PC12 cells. Mol Biol Cell. 2015;26:2858-72 pubmed publisher
	Sun Y, Almomani R, Aten E, Celli J, van der Heijden J, Venselaar H, et al. Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene. Am J Hum Genet. 2010;87:146-53 pubmed publisher
	Nakagawa K, Sugahara M, Yamasaki T, Kajiho H, Takahashi S, Hirayama J, et al. Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation. Biochem J. 2010;427:237-45 pubmed publisher
	Bedolla R, Wang Y, Asuncion A, Chamie K, Siddiqui S, Mudryj M, et al. Nuclear versus cytoplasmic localization of filamin A in prostate cancer: immunohistochemical correlation with metastases. Clin Cancer Res. 2009;15:788-96 pubmed publisher
	Beekman J, van der Poel C, van der Linden J, van den Berg D, van den Berghe P, van de Winkel J, et al. Filamin A stabilizes Fc gamma RI surface expression and prevents its lysosomal routing. J Immunol. 2008;180:3938-45 pubmed
	Lin J, Xu J, Tian H, Gao X, Chen Q, Gu Q, et al. Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis. Int J Cancer. 2007;121:2596-605 pubmed
	Lad Y, Kiema T, Jiang P, Pentikainen O, Coles C, Campbell I, et al. Structure of three tandem filamin domains reveals auto-inhibition of ligand binding. EMBO J. 2007;26:3993-4004 pubmed
	Smith S, Oxford G, Baras A, Owens C, Havaleshko D, Brautigan D, et al. Expression of ral GTPases, their effectors, and activators in human bladder cancer. Clin Cancer Res. 2007;13:3803-13 pubmed
	Wang Y, Kreisberg J, Bedolla R, Mikhailova M, deVere White R, Ghosh P. A 90 kDa fragment of filamin A promotes Casodex-induced growth inhibition in Casodex-resistant androgen receptor positive C4-2 prostate cancer cells. Oncogene. 2007;26:6061-70 pubmed
	Cukier I, Li Y, Lee J. Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin. FEBS Lett. 2007;581:1661-72 pubmed
	Mammoto A, Huang S, Ingber D. Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. J Cell Sci. 2007;120:456-67 pubmed
	Bachmann A, Howard J, Vogel C. Actin-binding protein filamin A is displayed on the surface of human neuroblastoma cells. Cancer Sci. 2006;97:1359-65 pubmed
	Park J, Kim H, Choy H, Kim K. Presence of presenilin 1/2 affects the invasion and replication of Salmonella typhimurium. Biochem Biophys Res Commun. 2005;332:1081-5 pubmed
	Flanagan L, Chou J, Falet H, Neujahr R, Hartwig J, Stossel T. Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. J Cell Biol. 2001;155:511-7 pubmed
	van der Ven P, Wiesner S, Salmikangas P, Auerbach D, Himmel M, Kempa S, et al. Indications for a novel muscular dystrophy pathway. gamma-filamin, the muscle-specific filamin isoform, interacts with myotilin. J Cell Biol. 2000;151:235-48 pubmed

product information

Catalog Number :

MAB1680

Subcategory :

Cell Structure

Product Name :

Anti-Filamin A Antibody, clone TI10

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P21333

Host Name :

Mouse

Antigen :

Filamin A

Clone :

TI10

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-Filamin A Antibody, clone TI10

Cross Reactivity :

Bovine;Human

Background :

Filamin is a structural protein that forms flexible cross-links between two actin filaments. Filamin is a homodimer of polypeptide chains each joined to the other at one end with an actin binding site ath the other. It is present in smooth muscle, fibroblasts, platelets and lymphocytes.

ALT Names :

Alpha-Filamin; Filamin I; Endothelial Actin-binding Protein; ABP-280; Nonmuscle Filamin

Immunogen :

Human platelet protein

Specificity :

Human filamin (actin-bidning protein). Recognizes unprocessed (270-280 kDa) and the C-terminal 90 kDa calpain cleavage fragment of filamin (Aakhus, 1992).

Package Size :

100 µL

Uses :

Immunoprecipitation;Western Blotting;Immunohistochemistry;Immunohistochemistry (Paraffin)

Storage :

Maintain frozen at -20°C for up to 12 months in undiluted aliquots. Avoid repeated freeze/thaw cycles.