Talin 1 Antibody, clone TA205, N-Term, Ascites Free | EMD Millipore MAB1676-C product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Talin 1 Antibody, clone TA205, N-Term, Ascites Free

catalog :

MAB1676-C

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TA205

The same clone is also sold as:

LifeSpan Biosciences: LS-C39479, LS-C188737
Bio-Rad: MCA725G
Novus Biologicals: NBP1-21642
Invitrogen: MA5-28133

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; human	Wang H, Sang N, Zhang C, Raghupathi R, Tanzi R, SAUNDERS A. Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. Biochemistry. 2015;54:2806-16 pubmed publisher
	Huang Z, Barker D, Gibbins J, Dash P. Talin is a substrate for SUMOylation in migrating cancer cells. Exp Cell Res. 2018;370:417-425 pubmed publisher
	Cook J, Ueno N, Lodoen M. Toxoplasma gondii disrupts β1 integrin signaling and focal adhesion formation during monocyte hypermotility. J Biol Chem. 2018;293:3374-3385 pubmed publisher
	Szeto S, Williams E, Rudner A, Lee J. Phosphorylation of filamin A by Cdk1 regulates filamin A localization and daughter cell separation. Exp Cell Res. 2015;330:248-66 pubmed publisher

product information

Catalog Number :

MAB1676-C

Subcategory :

Cell Signaling

Product Name :

Anti-Talin 1 Antibody, clone TA205, N-Term, Ascites Free

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9Y490

Host Name :

Mouse

Antigen :

TLN1

Clone :

TA205

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-Talin 1 Antibody, clone TA205, N-Term, Ascites Free

Cross Reactivity :

Human

Background :

Talin 1, also known as Talin 1, and encoded by the gene TLN1/KIAA1027, a large connecting protein located on the cytoplasmic side of most cellular projections. Talin appears to act as an anchoring protein connecting the cytoskeletal protein structures to the plasma membrane. Talin gets concentrated at regions of cell-substratum contact and in particular cells such as lymphocytes at regions of direct cell-cell contact. Talin 1 binds with high affinity to vinculin and interacts with other proteins found in cellular projections including focal adhesion kinases (FAK) and intermediate filament proteins such as synemin and layilin. Additionally, Talin 1 because of its connections with cytoskeletal proteins talin is associated with many vital cell motion/growth processes from axon guidance to cell migration, muscle contraction, cell-cell interactions, immune responses and platelet activation to name but a few.

ALT Names :

Talin-1

Immunogen :

GST-tagged recombinant protein corresponding to the N-terminus of human Talin 1.

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry (Paraffin), Immunoprecipitation, Inhibition, Immunofluorescence

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.