Neurofilament 200 kDa Antibody, CT, clone 3G3 | EMD Millipore MAB1623 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Neurofilament 200 kDa Antibody, CT, clone 3G3

catalog :

MAB1623

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3G3

The same clone is also sold as:

Abcam: ab19386
Invitrogen: MA1-2012

reactivity :

rat

application :

immunohistochemistry, immunocytochemistry

citations: 4

Reference
Gilbert M, Ramos R, McCloskey D, Goodman J. Subcortical band heterotopia in rat offspring following maternal hypothyroxinaemia: structural and functional characteristics. J Neuroendocrinol. 2014;26:528-41 pubmed publisher
Green J, Yang J, Grati M, Kachar B, Bhat M. Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons. BMC Neurosci. 2013;14:96 pubmed publisher
Lemons M. Characterizing Mystery Cell Lines: Student-driven Research Projects in an Undergraduate Neuroscience Laboratory Course. J Undergrad Neurosci Educ. 2012;10:A96-A104 pubmed
Hermann G, Van Meter M, Rogers R. CXCR4 receptors in the dorsal medulla: implications for autonomic dysfunction. Eur J Neurosci. 2008;27:855-64 pubmed publisher

product information

Catalog Number :

MAB1623

Subcategory :

Neuroscience

Product Name :

Anti-Neurofilament 200 kDa Antibody, CT, clone 3G3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P12036

Host Name :

Mouse

Antigen :

Neurofilament 200 kDa

Clone :

3G3

Conjugate :

Ascites

Isotype :

IgG

Product Description :

Anti-Neurofilament 200 kDa Antibody, CT, clone 3G3

Cross Reactivity :

Rat

Background :

Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm. They are the most abundant fibrillar components of the axon, being on average 3-10 times more frequent than axonal microtubules. Neurofilaments (10nm in dia.) are built from three intertwined protofibrils which are themselves composed of two tetrameric protofilament complexs of monomeric proteins. The neurofilament triplet proteins (68/70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are usually neuron specific. The 68/70 kDa NF-L protein can self-assemble into a filamentous structure, however the 160 kDa NF-M and 200 kDa NF-H proteins require the presence of the 68/70 kDa NF-L protein to co-assemble. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas and neuroblastomas stain positively for neurofilaments. Although typically restricted to neurons, neurofilaments have been detected in paragangliomas and adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilaments. For more neurofilament information see Nervous System Cell Type Specific Marker chart online under the CHEMICON Technical Support section.

Immunogen :

Recombinant fusion protein containing the C-terminal 226 amino acids of rat NF-H.

Specificity :

Strong reactivity on rat NF-H (200 kDa), somewhat weaker on other mammalian species. Does not recognize avian NF-H. Staining is not affected by the level of NF-H phosphorylation.

Package Size :

100 µL

Uses :

Immunocytochemistry;Immunohistochemistry

Storage :

Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.