Kinesin Antibody, heavy chain, a.a.420-445, clone H2 | EMD Millipore MAB1614 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Kinesin Antibody, heavy chain, a.a.420-445, clone H2

catalog :

MAB1614

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

H2

The same clone is also sold as:

LifeSpan Biosciences: LS-C58921, LS-C25019
OriGene: AM01168PU-N

reactivity :

African green monkey, human, mouse, rat, chicken

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, radioimmunoassay

citations: 30

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; loading ...; fig 3	Hendrickson A, Zhang C. Development of cone photoreceptors and their synapses in the human and monkey fovea. J Comp Neurol. 2019;527:38-51 pubmed publisher
immunoprecipitation; mouse; 1:300; loading ...; fig 2d western blot; mouse; loading ...; fig 2d	Han W, Wang H, Li J, Zhang S, Lu W. Ferric Chelate Reductase 1 Like Protein (FRRS1L) Associates with Dynein Vesicles and Regulates Glutamatergic Synaptic Transmission. Front Mol Neurosci. 2017;10:402 pubmed publisher
western blot; mouse; 1:500; fig 1b	Hinckelmann M, Virlogeux A, Niehage C, Poujol C, Choquet D, Hoflack B, et al. Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport. Nat Commun. 2016;7:13233 pubmed publisher
immunohistochemistry; mouse; 1:200; loading ...; fig 5a	Sadleir K, Kandalepas P, Buggia Prevot V, Nicholson D, Thinakaran G, Vassar R. Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease. Acta Neuropathol. 2016;132:235-56 pubmed publisher
western blot; African green monkey; loading ...; fig 1	Norris S, NÃºÃ±ez M, Verhey K. Influence of fluorescent tag on the motility properties of kinesin-1 in single-molecule assays. Biophys J. 2015;108:1133-43 pubmed publisher
western blot; rat	Han X, Cheng D, Song F, Zeng T, An L, Xie K. Decelerated transport and its mechanism of 2,5-hexanedione on middle-molecular-weight neurofilament in rat dorsal root ganglia cells. Neuroscience. 2014;269:192-8 pubmed publisher
western blot; mouse	Wong Y, Holzbaur E. The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation. J Neurosci. 2014;34:1293-305 pubmed publisher
	Nakaya T, Maragkakis M. Amyotrophic Lateral Sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicity. Sci Rep. 2018;8:15575 pubmed publisher
	Latremoliere A, Cheng L, DeLisle M, Wu C, Chew S, Hutchinson E, et al. Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration. Cell Rep. 2018;24:1865-1879.e9 pubmed publisher
	Hirano M, Muto M, Sakai M, Kondo H, Kobayashi S, Kariwa H, et al. Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A. 2017;114:9960-9965 pubmed publisher
	Padzik A, Deshpande P, Hollos P, Franker M, Rannikko E, Cai D, et al. KIF5C S176 Phosphorylation Regulates Microtubule Binding and Transport Efficiency in Mammalian Neurons. Front Cell Neurosci. 2016;10:57 pubmed publisher
	Bao L. Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons. Mol Pain. 2015;11:61 pubmed publisher
	Norris S, Soppina V, Dizaji A, Schimert K, Sept D, Cai D, et al. A method for multiprotein assembly in cells reveals independent action of kinesins in complex. J Cell Biol. 2014;207:393-406 pubmed publisher
	Blasius T, Reed N, Slepchenko B, Verhey K. Recycling of kinesin-1 motors by diffusion after transport. PLoS ONE. 2013;8:e76081 pubmed publisher
	Dilley A, Richards N, Pulman K, Bove G. Disruption of fast axonal transport in the rat induces behavioral changes consistent with neuropathic pain. J Pain. 2013;14:1437-49 pubmed publisher
	Rodriguez Martin T, Cuchillo Ibanez I, Noble W, Nyenya F, Anderton B, Hanger D. Tau phosphorylation affects its axonal transport and degradation. Neurobiol Aging. 2013;34:2146-57 pubmed publisher
	Sekigawa A, Fujita M, Sekiyama K, Takamatsu Y, Hatano T, Rockenstein E, et al. Distinct mechanisms of axonal globule formation in mice expressing human wild type ?-synuclein or dementia with Lewy bodies-linked P123H ?-synuclein. Mol Brain. 2012;5:34 pubmed publisher
	Lugli G, Larson J, Demars M, Smalheiser N. Primary microRNA precursor transcripts are localized at post-synaptic densities in adult mouse forebrain. J Neurochem. 2012;123:459-66 pubmed publisher
	Ohuchi H, Yamashita T, Tomonari S, Fujita Yanagibayashi S, Sakai K, Noji S, et al. A non-mammalian type opsin 5 functions dually in the photoreceptive and non-photoreceptive organs of birds. PLoS ONE. 2012;7:e31534 pubmed publisher
	Fort A, Murray J, Dandachi N, Davidson M, Dermietzel R, Wolkoff A, et al. In vitro motility of liver connexin vesicles along microtubules utilizes kinesin motors. J Biol Chem. 2011;286:22875-85 pubmed publisher
	Steuble M, Gerrits B, Ludwig A, Mateos J, Diep T, Tagaya M, et al. Molecular characterization of a trafficking organelle: dissecting the axonal paths of calsyntenin-1 transport vesicles. Proteomics. 2010;10:3775-88 pubmed publisher
	Shi P, Strom A, Gal J, Zhu H. Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport. Biochim Biophys Acta. 2010;1802:707-16 pubmed publisher
	Perlson E, Jeong G, Ross J, Dixit R, Wallace K, Kalb R, et al. A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration. J Neurosci. 2009;29:9903-17 pubmed publisher
	Her L, Goldstein L. Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin. J Neurosci. 2008;28:13662-72 pubmed publisher
	Cuchillo Ibanez I, Seereeram A, Byers H, Leung K, Ward M, Anderton B, et al. Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin. FASEB J. 2008;22:3186-95 pubmed publisher
	Butowt R, von Bartheld C. Conventional kinesin-I motors participate in the anterograde axonal transport of neurotrophins in the visual system. J Neurosci Res. 2007;85:2546-56 pubmed
	Ross J, Wallace K, Shuman H, Goldman Y, Holzbaur E. Processive bidirectional motion of dynein-dynactin complexes in vitro. Nat Cell Biol. 2006;8:562-70 pubmed
	Utton M, Noble W, Hill J, Anderton B, Hanger D. Molecular motors implicated in the axonal transport of tau and alpha-synuclein. J Cell Sci. 2005;118:4645-54 pubmed
	Patel S, Richardson J, Schulze H, Kahle E, Galjart N, Drabek K, et al. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood. 2005;106:4076-85 pubmed
	Muresan Z, Muresan V. c-Jun NH2-terminal kinase-interacting protein-3 facilitates phosphorylation and controls localization of amyloid-beta precursor protein. J Neurosci. 2005;25:3741-51 pubmed

product information

Catalog Number :

MAB1614

Subcategory :

Cell Structure

Product Name :

Anti-Kinesin Antibody, heavy chain, a.a.420-445, clone H2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P33176

Host Name :

Mouse

Antigen :

Kinesin

Clone :

Conjugate :

Purified

Isotype :

IgG2b

Product Description :

Anti-Kinesin Antibody, heavy chain, a.a.420-445, clone H2

Cross Reactivity :

Chicken;Mammals;Squid;Sea Urchin;Human;Mouse;Rat

Background :

Kinesins are molecular motors used for intracellular transport and trafficking. They move along microtubule cables powered by the hydrolysis of ATP, thus kinesins are ATPases. The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cargo such as axonal transport.

Immunogen :

Bovine brain kinesin.

Specificity :

Reacts with the heavy chain of kinesin near the N-terminus.

Package Size :

100 µg

Uses :

ELISA;Immunocytochemistry;Immunohistochemistry;Immunoprecipitation;Affects Function;Radioimmunoassay;Western Blotting

Storage :

Stable for 6 months at 2-8°C in undiluted aliquots from date of receipt.