Neurofilament H & M Antibody, phosphorylated, clone NP1 | EMD Millipore MAB1592 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Neurofilament H & M Antibody, phosphorylated, clone NP1

catalog :

MAB1592

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

NP1

reactivity :

human, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, radioimmunoassay, immunohistochemistry - paraffin section, immunohistochemistry - free floating section

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - free floating section; rat; 1:500; loading ...; fig 1a western blot; rat; 1:500; loading ...; fig 1c	Udovin L, Kobiec T, Herrera M, Toro Urrego N, Kusnier C, Kolliker Frers R, et al. Partial Reversal of Striatal Damage by Palmitoylethanolamide Administration Following Perinatal Asphyxia. Front Neurosci. 2019;13:1345 pubmed publisher
immunohistochemistry; human; loading ...; fig s6e	Vijayaraj P, Minasyan A, Durra A, Karumbayaram S, Mehrabi M, Aros C, et al. Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule. Cell Rep. 2019;29:3488-3505.e9 pubmed publisher
	Aven L, Paez Cortez J, Achey R, Krishnan R, Ram Mohan S, Cruikshank W, et al. An NT4/TrkB-dependent increase in innervation links early-life allergen exposure to persistent airway hyperreactivity. FASEB J. 2014;28:897-907 pubmed publisher
	Lanciego J, Vázquez A. The basal ganglia and thalamus of the long-tailed macaque in stereotaxic coordinates. A template atlas based on coronal, sagittal and horizontal brain sections. Brain Struct Funct. 2012;217:613-66 pubmed publisher
	Tremblay P, Cloutier R, Lamontagne J, Belzil A, Larkin A, Chouinard L, et al. Potential of skin fibroblasts for application to anterior cruciate ligament tissue engineering. Cell Transplant. 2011;20:535-42 pubmed publisher
	Valasek P, Macharia R, Neuhuber W, Wilting J, Becker D, Patel K. Lymph heart in chick--somitic origin, development and embryonic oedema. Development. 2007;134:4427-36 pubmed
	Camarillo C, Kumar L, Bake S, Sohrabji F, Miranda R. Ethanol regulates angiogenic cytokines during neural development: evidence from an in vitro model of mitogen-withdrawal-induced cerebral cortical neuroepithelial differentiation. Alcohol Clin Exp Res. 2007;31:324-35 pubmed

product information

Catalog Number :

MAB1592

Subcategory :

Neuroscience

Product Name :

Anti-Neurofilament H & M Antibody, phosphorylated, clone NP1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P12036;P07197

Host Name :

Mouse

Antigen :

Neurofilament H & M

Clone :

NP1

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-Neurofilament H & M Antibody, phosphorylated, clone NP1

Cross Reactivity :

Bovine;Chicken;Human;Rat

Background :

Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm. They are the most abundant fibrillar components of the axon, being on average 3-10 times more frequent than axonal microtubules. Neurofilaments (10nm in dia.) are built from three intertwined protofibrils which are themselves composed of two tetrameric protofilament complexs of monomeric proteins. The neurofilament triplet proteins (68/70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are usually neuron specific. The 68/70 kDa NF-L protein can self-assemble into a filamentous structure, however the 160 kDa NF-M and 200 kDa NF-H proteins require the presence of the 68/70 kDa NF-L protein to co-assemble. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas and neuroblastomas stain positively for neurofilaments. Although typically restricted to neurons, neurofilaments have been detected in paragangliomas and adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilaments. For more neurofilament information see Nervous System Cell Type Specific Marker chart online under the CHEMICON Technical Support section.

Immunogen :

Bovine neurofilaments

Specificity :

Recognizes the KSP repeats of the phosphorylated forms of neurofilament-M (NF-M) and neurofilament-H (NF-H), because NF-L does contain a few of these Lysine-serine-PO4-proline repeats some cross reactivity to NF-L may be seen at very high antibody concentrations.

Package Size :

100 µL

Uses :

ELISA;Flow Cytometry;Radioimmunoassay;Western Blotting;Immunocytochemistry;Immunohistochemistry (Paraffin)

Storage :

Maintain at -20°C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles.