This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Myelin Associated Glycoprotein Antibody, clone 513
catalog :
MAB1567
quantity :
100 μg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
513
reactivity :
human, mouse, rat, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
citations: 40
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:400; loading ...; fig 1g
Kjell J, Fischer Sternjak J, Thompson A, Friess C, Sticco M, Salinas F, et al. Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis. Cell Stem Cell. 2020;26:277-293.e8 pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig 1b
Erwig M, Patzig J, Steyer A, Dibaj P, Heilmann M, Heilmann I, et al. Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin. elife. 2019;8: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig s3
Barlow Anacker A, Fu M, Erickson C, Bertocchini F, Gosain A. Neural Crest Cells Contribute an Astrocyte-like Glial Population to the Spleen. Sci Rep. 2017;7:45645 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 7h
Ercan E, Han J, Di Nardo A, Winden K, Han M, Hoyo L, et al. Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex. J Exp Med. 2017;214:681-697 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250; loading ...
Yoshikawa F, Sato Y, Tohyama K, Akagi T, Furuse T, Sadakata T, et al. Mammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral Assessments. PLoS ONE. 2016;11:e0166732 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s1b
Safaiyan S, Kannaiyan N, Snaidero N, Brioschi S, Biber K, Yona S, et al. Age-related myelin degradation burdens the clearance function of microglia during aging. Nat Neurosci. 2016;19:995-8 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:400; fig 1i
Nagao M, Ogata T, Sawada Y, Gotoh Y. Zbtb20 promotes astrocytogenesis during neocortical development. Nat Commun. 2016;7:11102 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; fig 1
Eckharter C, Junker N, Winter L, Fischer I, Fogli B, Kistner S, et al. Schwann Cell Expressed Nogo-B Modulates Axonal Branching of Adult Sensory Neurons Through the Nogo-B Receptor NgBR. Front Cell Neurosci. 2015;9:454 pubmed publisher
  • flow cytometry; human; fig 1b
van Nierop G, Janssen M, Mitterreiter J, van de Vijver D, De Swart R, Haagmans B, et al. Intrathecal CD4(+) and CD8(+) T-cell responses to endogenously synthesized candidate disease-associated human autoantigens in multiple sclerosis patients. Eur J Immunol. 2016;46:347-53 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 2c
  • western blot; mouse; 1:500; loading ...; fig 5g
Patzig J, Kusch K, Fledrich R, Eichel M, Lüders K, Möbius W, et al. Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking. Glia. 2016;64:155-74 pubmed publisher
  • immunocytochemistry; mouse; 1:200; tbl 1
Hirata H, Umemori J, Yoshioka H, Koide T, Watanabe K, Shimoda Y. Cell adhesion molecule contactin-associated protein 3 is expressed in the mouse basal ganglia during early postnatal stages. J Neurosci Res. 2016;94:74-89 pubmed publisher
  • western blot; rat; 1:1000; fig 4
Nishimoto S, Tanaka H, Okamoto M, Okada K, Murase T, Yoshikawa H. Methylcobalamin promotes the differentiation of Schwann cells and remyelination in lysophosphatidylcholine-induced demyelination of the rat sciatic nerve. Front Cell Neurosci. 2015;9:298 pubmed publisher
  • immunocytochemistry; mouse; fig 1
Linden J, Ma Y, Zhao B, Harris J, Rumah K, Schaeren Wiemers N, et al. Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination. MBio. 2015;6:e02513 pubmed publisher
  • immunocytochemistry; rat; loading ...; fig 1b
Hao W, Tashiro S, Hasegawa T, Sato Y, Kobayashi T, Tando T, et al. Hyperglycemia Promotes Schwann Cell De-differentiation and De-myelination via Sorbitol Accumulation and Igf1 Protein Down-regulation. J Biol Chem. 2015;290:17106-15 pubmed publisher
  • immunohistochemistry; mouse
Shimizu S, Koyama Y, Hattori T, Tachibana T, Yoshimi T, Emoto H, et al. DBZ, a CNS-specific DISC1 binding protein, positively regulates oligodendrocyte differentiation. Glia. 2014;62:709-24 pubmed publisher
  • immunohistochemistry; mouse; 1:250
Viganò F, Mobius W, Gotz M, Dimou L. Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain. Nat Neurosci. 2013;16:1370-2 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000
Ruff C, Ye H, Legasto J, Stribbell N, Wang J, Zhang L, et al. Effects of adult neural precursor-derived myelination on axonal function in the perinatal congenitally dysmyelinated brain: optimizing time of intervention, developing accurate prediction models, and enhancing performance. J Neurosci. 2013;33:11899-915 pubmed publisher
  • western blot; mouse; 1:1000
Clark K, Sakowski L, Sperle K, Banser L, Landel C, Bessert D, et al. Gait abnormalities and progressive myelin degeneration in a new murine model of Pelizaeus-Merzbacher disease with tandem genomic duplication. J Neurosci. 2013;33:11788-99 pubmed publisher
Huang H, Teng P, Du J, Meng J, Hu X, Tang T, et al. Interactive Repression of MYRF Self-Cleavage and Activity in Oligodendrocyte Differentiation by TMEM98 Protein. J Neurosci. 2018;38:9829-9839 pubmed publisher
Bruce K, Gorkhali S, Given K, Coates A, Boyle K, Macklin W, et al. Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination. Front Mol Neurosci. 2018;11:57 pubmed publisher
Dillenburg A, Ireland G, Holloway R, Davies C, Evans F, Swire M, et al. Activin receptors regulate the oligodendrocyte lineage in health and disease. Acta Neuropathol. 2018;135:887-906 pubmed publisher
Bhagat S, Butler S, Taylor J, McEwen B, Strittmatter S. Erasure of fear memories is prevented by Nogo Receptor 1 in adulthood. Mol Psychiatry. 2016;21:1281-9 pubmed publisher
O Guin K, Gruber R, Raine C, Guzik H, Poulos B, Shafit Zagardo B. Gas6 enhances axonal ensheathment by MBP+ membranous processes in human DRG/OL promyelinating co-cultures. ASN Neuro. 2014;6:e00135 pubmed publisher
Christensen P, Brideau C, Poon K, Döring A, Yong V, Stys P. High-resolution fluorescence microscopy of myelin without exogenous probes. Neuroimage. 2014;87:42-54 pubmed publisher
Vajn K, Viljetić B, Degmecić I, Schnaar R, Heffer M. Differential distribution of major brain gangliosides in the adult mouse central nervous system. PLoS ONE. 2013;8:e75720 pubmed publisher
Najm F, Lager A, Zaremba A, Wyatt K, Caprariello A, Factor D, et al. Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Nat Biotechnol. 2013;31:426-33 pubmed publisher
Goolsby J, Makar T, Dhib Jalbut S, Bever C, Pessac B, Trisler D. Hematopoietic progenitors express myelin basic protein and ensheath axons in Shiverer brain. J Neuroimmunol. 2013;257:13-20 pubmed publisher
Xiao J, Hughes R, Lim J, Wong A, Ivanusic J, Ferner A, et al. A small peptide mimetic of brain-derived neurotrophic factor promotes peripheral myelination. J Neurochem. 2013;125:386-98 pubmed publisher
Ivanovic A, Horresh I, Golan N, Spiegel I, Sabanay H, Frechter S, et al. The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves. J Cell Biol. 2012;196:337-44 pubmed publisher
Tolcos M, Bateman E, O Dowd R, Markwick R, Vrijsen K, Rehn A, et al. Intrauterine growth restriction affects the maturation of myelin. Exp Neurol. 2011;232:53-65 pubmed publisher
Callizot N, Combes M, Steinschneider R, Poindron P. A new long term in vitro model of myelination. Exp Cell Res. 2011;317:2374-83 pubmed publisher
Li F, Fowler K, Neil J, Colton C, Vitek M. An apolipoprotein E-mimetic stimulates axonal regeneration and remyelination after peripheral nerve injury. J Pharmacol Exp Ther. 2010;334:106-15 pubmed publisher
Rompani S, Cepko C. A common progenitor for retinal astrocytes and oligodendrocytes. J Neurosci. 2010;30:4970-80 pubmed publisher
Fatemi S, Folsom T, Reutiman T, Abu Odeh D, Mori S, Huang H, et al. Abnormal expression of myelination genes and alterations in white matter fractional anisotropy following prenatal viral influenza infection at E16 in mice. Schizophr Res. 2009;112:46-53 pubmed publisher
Wörter V, Schweigreiter R, Kinzel B, Mueller M, Barske C, Böck G, et al. Inhibitory activity of myelin-associated glycoprotein on sensory neurons is largely independent of NgR1 and NgR2 and resides within Ig-Like domains 4 and 5. PLoS ONE. 2009;4:e5218 pubmed publisher
Hoshikawa S, Ogata T, Fujiwara S, Nakamura K, Tanaka S. A novel function of RING finger protein 10 in transcriptional regulation of the myelin-associated glycoprotein gene and myelin formation in Schwann cells. PLoS ONE. 2008;3:e3464 pubmed publisher
Mann S, Versmold B, Marx R, Stahlhofen S, Dietzel I, Heumann R, et al. Corticosteroids reverse cytokine-induced block of survival and differentiation of oligodendrocyte progenitor cells from rats. J Neuroinflammation. 2008;5:39 pubmed publisher
Felitsyn N, McLeod C, Shroads A, Stacpoole P, Notterpek L. The heme precursor delta-aminolevulinate blocks peripheral myelin formation. J Neurochem. 2008;106:2068-79 pubmed publisher
Cheng S, Carr C. Functional delay of myelination of auditory delay lines in the nucleus laminaris of the barn owl. Dev Neurobiol. 2007;67:1957-74 pubmed
Tomita K, Kubo T, Matsuda K, Yano K, Tohyama M, Hosokawa K. Myelin-associated glycoprotein reduces axonal branching and enhances functional recovery after sciatic nerve transection in rats. Glia. 2007;55:1498-507 pubmed
product information
Catalog Number :
MAB1567
Subcategory :
Neuroscience
Product Name :
Anti-Myelin Associated Glycoprotein Antibody, clone 513
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P20916
Host Name :
Mouse
Antigen :
Myelin Associated Glycoprotein
Clone :
513
Conjugate :
Purified
Isotype :
IgG1
Product Description :
Anti-Myelin Associated Glycoprotein Antibody, clone 513
Cross Reactivity :
Bovine;Chicken;Human;Mouse;Rat;Frog
Background :
Myelin-associated glycoprotein (MAG),a member of the immunoglobulin superfamily, is a membrane glycoprotein of 100 kDa, and is thought to be involved in the process of myelination. Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and MAG. MAG has been implicated in the inhibition of nerve regeneration in the CNS.
ALT Names :
MAG
Immunogen :
L2 epitope carrying glycoprotein extract of 1-2 day old chicken brain.
Specificity :
Detects Myelin Associated Glycoprotein (MAG) in immunohistochemistry on frozen sections, immunocytochemistry and Western blot (under non-reducing conditions). MAB1567 is useful for myelinogenesis and multiple sclerosis studies.
Package Size :
100 μg
Uses :
Immunocytochemistry;Immunohistochemistry;Western Blotting
Storage :
Stable for 1 year at -20ºC from date of receipt.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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